Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.56 (caspase-3)
35,750 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 35429
Bcl-2 7976
caspase-9 4746
cytochrome c 4160
p53 3259
Mol 3217
caspase-8 3202
PARP 3025
Sep 2325
annexin V 1657
p38 1586
Fas 1553
TNF 1552
tumor necrosis factor 1448
superoxide dismutase 1359
GSH 1239
JNK 1138
poly(ADP-ribose) polymerase 1130
p21 1105
ROS 1073
MAPK 1016
PI3K 1002
endoplasmic reticulum 986
catalase 975
lactate dehydrogenase 915
cytokine 900
ERK 885
AKT 884
cytochrome 851
ERK1 850
ATP 825
bcl-2 812
IL-6 780
Bid 700
inducible nitric oxide synthase 668
survivin 650
mTOR 641
poly (ADP-ribose) polymerase 625
cyclin D1 620
glutathione peroxidase 618
more...
Disease
cancer 7334
tumor 4651
ischemia 1568
GSH 1240
leukemia 1173
tumor growth 1128
breast cancer 1126
carcinoma 1039
hepatocellular carcinoma 1013
Alzheimer's disease 886
B-cell lymphoma 766
MCF 763
diabetes 740
neuroblastoma 670
lung cancer 653
colon cancer 651
stroke 594
Parkinson's disease 586
prostate cancer 586
cerebral ischemia 552
melanoma 525
adenocarcinoma 518
carcinogenesis 432
colorectal cancer 432
tumorigenesis 412
gastric cancer 387
glioma 383
lymphoma 369
squamous cell carcinoma 335
ovarian cancer 328
osteosarcoma 318
cervical cancer 301
non-small cell lung cancer 282
myocardial ischemia 282
glioblastoma 280
pancreatic cancer 251
liver cancer 246
multiple myeloma 244
atherosclerosis 237
myocardial infarction 234
more...
Symptom
collapse 252
seizures 168
starvation 150
functional recovery 137
anesthesia 113
pain 92
hypothermia 71
diarrhea 61
hyperoxia 61
respiratory distress 40
weakness 27
memory loss 27
thinning 25
ataxia 21
cachexia 19
skin damage 19
tremor 18
bradykinesia 17
exhaustion 15
acute stress 13
vomiting 12
fatigue 12
acidity 11
HSA 9
headache 8
analgesia 8
erythema 8
hypercapnia 7
overweight 7
angina 7
cough 7
dry eye 7
nausea 7
incoordination 7
neurological disability 6
abdominal pain 6
back pain 5
anorexia 5
Scratch 5
Neuropathic pain 5
more...
Drug
ROS 1073
Monit 151
ascorbate 120
MAP 112
vitamin E 107
Dermatol 104
lysine 103
Cardiovasc 97
IFN-gamma 96
IL-2 92
Ethanol 84
Arsenic trioxide 73
AMC 66
CED 64
CSF 59
p75 56
Taxol 53
Glutathione 51
caffeine 47
TTC 46
CTX 45
Bortezomib 43
ICI 41
Simvastatin 40
Indomethacin 40
MRC 38
Heme 36
ZnO 36
Sorafenib 34
Imatinib 34
Glycyrrhiza 33
TAT 32
Propofol 32
Ginseng 32
Etoposide 32
Angiotensin II 31
EE2 31
NADH 30
Fluorescein 28
CPT-11 28
more...
Enzyme
caspase-3 35750
caspase-9 4691
mitogen-activated protein kinase 3450
PARP 3345
caspase-8 3091
superoxide dismutase 1778
ERK 1219
catalase 1117
protein kinase 1071
lactate dehydrogenase 937
caspase-1 741
glutathione peroxidase 626
caspase-7 551
caspase-7 532
alanine aminotransferase 433
protein kinase C 430
proteasome 424
focal adhesion kinase 422
luciferase 410
MEK 382
aspartate aminotransferase 374
peroxidase 343
phosphatidylinositol 3-kinase 342
GSK 305
caspase-2 298
caspase-2 289
cdc2 270
caspase-6 252
AMP-activated protein kinase 243
caspase-6 231
creatine kinase 212
NADPH oxidase 206
phosphoinositide 3-kinase 194
NADPH oxidase 192
ATPase 184
TdT 180
tyrosine hydroxylase 157
glutathione S-transferase 156
AMPK 153
glutathione reductase 144
more...
Compound
DNA 6730
oxygen 4966
Dec 2510
MTT 2292
TNF 1552
glucose 1324
GSH 1266
GSH 1266
dUTP 1263
calcium 1090
water 1012
nitric oxide 961
cysteine 950
iodine 898
MDA 859
ATP 825
hydrogen 740
Asp 716
bromide 685
ADP-ribose 662
sodium 613
Clin 568
N-acetylcysteine 508
glutamate 459
H2O2 453
ethanol 438
alanine 406
serine 382
tyrosine 379
ADP 368
nitrogen 359
creatinine 348
urea 324
ADP 315
ADP 314
zinc 300
DDP 291
phosphate 261
iron 243
arginine 243
more...