Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.56 (
caspase-3
)
35,750
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
caspase-3
35429
Bcl-2
7976
caspase-9
4746
cytochrome c
4160
p53
3259
Mol
3217
caspase-8
3202
PARP
3025
Sep
2325
annexin V
1657
p38
1586
Fas
1553
TNF
1552
tumor necrosis factor
1448
superoxide dismutase
1359
GSH
1239
JNK
1138
poly(ADP-ribose) polymerase
1130
p21
1105
ROS
1073
MAPK
1016
PI3K
1002
endoplasmic reticulum
986
catalase
975
lactate dehydrogenase
915
cytokine
900
ERK
885
AKT
884
cytochrome
851
ERK1
850
ATP
825
bcl-2
812
IL-6
780
Bid
700
inducible nitric oxide synthase
668
survivin
650
mTOR
641
poly (ADP-ribose) polymerase
625
cyclin D1
620
glutathione peroxidase
618
more...
Disease
cancer
7334
tumor
4651
ischemia
1568
GSH
1240
leukemia
1173
tumor growth
1128
breast cancer
1126
carcinoma
1039
hepatocellular carcinoma
1013
Alzheimer's disease
886
B-cell lymphoma
766
MCF
763
diabetes
740
neuroblastoma
670
lung cancer
653
colon cancer
651
stroke
594
Parkinson's disease
586
prostate cancer
586
cerebral ischemia
552
melanoma
525
adenocarcinoma
518
carcinogenesis
432
colorectal cancer
432
tumorigenesis
412
gastric cancer
387
glioma
383
lymphoma
369
squamous cell carcinoma
335
ovarian cancer
328
osteosarcoma
318
cervical cancer
301
non-small cell lung cancer
282
myocardial ischemia
282
glioblastoma
280
pancreatic cancer
251
liver cancer
246
multiple myeloma
244
atherosclerosis
237
myocardial infarction
234
more...
Symptom
collapse
252
seizures
168
starvation
150
functional recovery
137
anesthesia
113
pain
92
hypothermia
71
diarrhea
61
hyperoxia
61
respiratory distress
40
weakness
27
memory loss
27
thinning
25
ataxia
21
cachexia
19
skin damage
19
tremor
18
bradykinesia
17
exhaustion
15
acute stress
13
vomiting
12
fatigue
12
acidity
11
HSA
9
headache
8
analgesia
8
erythema
8
hypercapnia
7
overweight
7
angina
7
cough
7
dry eye
7
nausea
7
incoordination
7
neurological disability
6
abdominal pain
6
back pain
5
anorexia
5
Scratch
5
Neuropathic pain
5
more...
Drug
ROS
1073
Monit
151
ascorbate
120
MAP
112
vitamin E
107
Dermatol
104
lysine
103
Cardiovasc
97
IFN-gamma
96
IL-2
92
Ethanol
84
Arsenic trioxide
73
AMC
66
CED
64
CSF
59
p75
56
Taxol
53
Glutathione
51
caffeine
47
TTC
46
CTX
45
Bortezomib
43
ICI
41
Simvastatin
40
Indomethacin
40
MRC
38
Heme
36
ZnO
36
Sorafenib
34
Imatinib
34
Glycyrrhiza
33
TAT
32
Propofol
32
Ginseng
32
Etoposide
32
Angiotensin II
31
EE2
31
NADH
30
Fluorescein
28
CPT-11
28
more...
Enzyme
caspase-3
35750
caspase-9
4691
mitogen-activated protein kinase
3450
PARP
3345
caspase-8
3091
superoxide dismutase
1778
ERK
1219
catalase
1117
protein kinase
1071
lactate dehydrogenase
937
caspase-1
741
glutathione peroxidase
626
caspase-7
551
caspase-7
532
alanine aminotransferase
433
protein kinase C
430
proteasome
424
focal adhesion kinase
422
luciferase
410
MEK
382
aspartate aminotransferase
374
peroxidase
343
phosphatidylinositol 3-kinase
342
GSK
305
caspase-2
298
caspase-2
289
cdc2
270
caspase-6
252
AMP-activated protein kinase
243
caspase-6
231
creatine kinase
212
NADPH oxidase
206
phosphoinositide 3-kinase
194
NADPH oxidase
192
ATPase
184
TdT
180
tyrosine hydroxylase
157
glutathione S-transferase
156
AMPK
153
glutathione reductase
144
more...
Compound
DNA
6730
oxygen
4966
Dec
2510
MTT
2292
TNF
1552
glucose
1324
GSH
1266
GSH
1266
dUTP
1263
calcium
1090
water
1012
nitric oxide
961
cysteine
950
iodine
898
MDA
859
ATP
825
hydrogen
740
Asp
716
bromide
685
ADP-ribose
662
sodium
613
Clin
568
N-acetylcysteine
508
glutamate
459
H2O2
453
ethanol
438
alanine
406
serine
382
tyrosine
379
ADP
368
nitrogen
359
creatinine
348
urea
324
ADP
315
ADP
314
zinc
300
DDP
291
phosphate
261
iron
243
arginine
243
more...