Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.56 (caspase-3)
 35,750 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 35429
Bcl-2 7976
caspase-9 4746
cytochrome c 4160
p53 3259
Mol 3217
caspase-8 3202
PARP 3025
Sep 2325
annexin V 1657
p38 1586
Fas 1553
TNF 1552
tumor necrosis factor 1448
superoxide dismutase 1359
GSH 1239
JNK 1138
poly(ADP-ribose) polymerase 1130
p21 1105
ROS 1073
MAPK 1016
PI3K 1002
endoplasmic reticulum 986
catalase 975
lactate dehydrogenase 915
cytokine 900
ERK 885
AKT 884
cytochrome 851
ERK1 850
ATP 825
bcl-2 812
IL-6 780
Bid 700
inducible nitric oxide synthase 668
survivin 650
mTOR 641
poly (ADP-ribose) polymerase 625
cyclin D1 620
glutathione peroxidase 618
CPP32 612
c-Jun 596
insulin 589
p65 554
bax 552
anti-apoptotic protein 525
lipopolysaccharide 524
proliferating cell nuclear antigen 521
LC3 519
calpain 467
SOD 464
XIAP 464
extracellular signal-regulated kinase 441
Mcl-1 430
BAX 427
LDH 418
proteasome 415
Bax protein 410
Fas ligand 396
Bak 388
kit 387
collagen 385
p27 376
vascular endothelial growth factor 373
heme oxygenase-1 372
inhibitor of apoptosis 365
FasL 363
apoptosis-inducing factor 355
TNF-alpha 353
PARP-1 344
protein kinase B 343
phosphatidylinositol 3-kinase 342
CHOP 335
cyclooxygenase-2 335
mitogen-activated protein 325
pro-apoptotic protein 324
COX-2 319
catenin 318
Nrf2 316
ADP 314
Apaf-1 314
Ki-67 308
CA1 304
p38 mitogen-activated protein kinase 302
TdT 297
MMP-9 296
VEGF 292
STAT3 289
interleukin-6 286
osteosarcoma 284
glial fibrillary acidic protein 279
erythroid 278
cyclin B1 277
ubiquitin 276
histone 276
GRP78 275
myeloperoxidase 274
brain-derived neurotrophic factor 274
CCK 272
GSK 271
CD95 269
TRAIL 260
Bcl-X 260
nitric oxide synthase 259
aspartate aminotransferase 256
alanine aminotransferase 256
PC-3 255
Smac 253
IL-10 251
cyclin 249
MEK 248
p62 247
Beclin-1 245
HO-1 234
tyrosine kinase 230
matrix metalloproteinase 230
LPS 228
cyclin E 225
IFN 223
HSP70 220
FADD 210
AIF 210
H2AX 208
amyloid precursor protein 206
antioxidant enzyme 204
histone deacetylase 203
tumor necrosis factor alpha 198
proteasome inhibitor 198
C/EBP homologous protein 195
phosphoinositide 3-kinase 194
TLR4 194
cysteine protease 191
cyclin A 189
PKC 187
MMP-2 183
X-linked inhibitor of apoptosis protein 183
IL-8 182
CD4 180
DR5 178
PTEN 175
c-Myc 175
E-cadherin 175
Tumor necrosis factor 174
ATPase 173
creatine kinase 171
interferon 170
estrogen receptor 170
CDK4 167
DIABLO 165
epidermal growth factor receptor 163
CDK2 162
tyrosine hydroxylase 158
phosphatase 155
CAT 155
JNK1 154
CD8 154
colon carcinoma 148
PERK 148
NMR 148
THP 144
more...
Disease
cancer 7334
tumor 4651
ischemia 1568
GSH 1240
leukemia 1173
tumor growth 1128
breast cancer 1126
carcinoma 1039
hepatocellular carcinoma 1013
Alzheimer's disease 886
B-cell lymphoma 766
MCF 763
diabetes 740
neuroblastoma 670
lung cancer 653
colon cancer 651
stroke 594
Parkinson's disease 586
prostate cancer 586
cerebral ischemia 552
melanoma 525
adenocarcinoma 518
carcinogenesis 432
colorectal cancer 432
tumorigenesis 412
gastric cancer 387
glioma 383
lymphoma 369
squamous cell carcinoma 335
ovarian cancer 328
osteosarcoma 318
cervical cancer 301
myocardial ischemia 282
non-small cell lung cancer 282
glioblastoma 280
pancreatic cancer 251
liver cancer 246
multiple myeloma 244
atherosclerosis 237
myocardial infarction 234
hyperglycemia 229
sepsis 226
sepsis 220
acute promyelocytic leukemia 217
tumor progression 209
cognitive impairment 208
acute myeloid leukemia 199
DDP 194
liver cancer 194
chronic myeloid leukemia 190
lung carcinoma 180
heart failure 177
pheochromocytoma 174
bladder cancer 161
type 2 diabetes 157
HIV 156
retinoblastoma 151
depression 147
virus infection 142
hypertension 139
osteoarthritis 133
ATM 133
dementia 130
obesity 127
MTS 127
metastases 127
Huntington's disease 125
AGS 121
memory impairment 118
cold 115
subarachnoid hemorrhage 113
cardiovascular disease 113
acute lymphoblastic leukemia 113
rheumatoid arthritis 113
amyotrophic lateral sclerosis 112
diabetic nephropathy 111
skin cancer 109
brain edema 107
SCID 106
Blocking 102
epithelial ovarian cancer 101
epilepsy 100
liver fibrosis 100
FAS 100
plaque 98
infectious diseases 95
renal disease 94
Leukemia 94
colitis 94
NAME 92
renal ischemia 92
Hepatocellular carcinoma 91
solid tumor 91
renal cell carcinoma 90
oral cancer 89
diabetic retinopathy 88
immunodeficiency 85
glioblastoma multiforme 85
cerebral infarction 84
osteoporosis 83
cardiomyopathy 81
CEM 79
esophageal cancer 79
myeloid leukemia 78
multiple sclerosis 78
Pineal 76
brain tumor 75
Melanoma 74
Osteosarcoma 74
Osteosarcoma 74
asthma 74
hepatitis 72
esophageal cancer 70
type 1 diabetes 69
Infection 69
herpes simplex 68
acute myocardial infarction 68
liver disease 67
encephalopathy 66
chronic lymphocytic leukemia 66
muscular atrophy 65
inflammatory bowel disease 63
TEM 61
arthritis 60
endometrial cancer 59
TEM 58
coronary artery disease 58
status epilepticus 57
chronic lymphocytic leukemia 56
NOD 54
Glioblastoma 54
fatty liver 54
SDS 53
glaucoma 53
tuberculosis 52
sarcoma 52
primary tumor 51
cirrhosis 51
Hodgkin's disease 51
diabetic cardiomyopathy 51
parkinsonism 51
AIDS 51
suicide 50
chronic obstructive pulmonary disease 49
insulinoma 49
Neuroblastoma 49
fibrosarcoma 49
influenza 49
Neuroblastoma 49
tumor angiogenesis 48
autoimmune disease 48
infertility 47
pertussis 47
Burkitt's lymphoma 47
ulcerative colitis 47
acute renal failure 46
systemic lupus erythematosus 46
proteinuria 46
Mycobacterium 46
emphysema 45
more...
Symptom
collapse 252
seizures 168
starvation 150
functional recovery 137
anesthesia 113
pain 92
hypothermia 71
diarrhea 61
hyperoxia 61
respiratory distress 40
memory loss 27
weakness 27
thinning 25
ataxia 21
cachexia 19
skin damage 19
tremor 18
bradykinesia 17
exhaustion 15
acute stress 13
fatigue 12
vomiting 12
acidity 11
HSA 9
erythema 8
headache 8
analgesia 8
angina 7
cough 7
nausea 7
dry eye 7
incoordination 7
overweight 7
hypercapnia 7
neurological disability 6
abdominal pain 6
anorexia 5
back pain 5
Scratch 5
Neuropathic pain 5
cerebellar ataxia 4
chorea 4
stomach pain 4
constipation 4
Anoxia 4
sore throat 4
insomnia 4
low back pain 4
splenomegaly 4
chest pain 3
dyspnea 3
dizziness 3
dystonia 3
tachypnea 3
hypotonia 3
POA 3
hepatomegaly 3
hepatosplenomegaly 3
physical appearance 2
spasticity 2
pelvic pain 2
loss of balance 2
despair 2
tinnitus 2
bitter taste 2
disturbed balance 2
halitosis 2
Motor dysfunction 2
forgetfulness 2
acute pain 2
Tenderness 2
lethargy 2
menopausal symptoms 2
catatonia 1
ataxic gait 1
startle reaction 1
paraparesis 1
eds 1
loss of taste 1
agitation 1
chronic constipation 1
nasal discharge 1
Joint hypermobility 1
pallor 1
Decreased activity 1
Ear swelling 1
clubbing 1
infant diarrhea 1
anosmia 1
DNA marker 1
tonic-clonic seizure 1
sleepiness 1
motor symptom 1
Chronic pelvic pain syndrome 1
hyperemesis 1
arthralgia 1
otalgia 1
Acute urinary retention 1
ketonuria 1
blurred vision 1
abnormal gait 1
distraction 1
asthenia 1
impaired motor coordination 1
heartburn 1
stigma 1
hemiplegia 1
nausea and vomiting 1
male subfertility 1
myalgia 1
twitching 1
personality change 1
vertigo 1
hyperesthesia 1
Behavioral symptoms 1
bone pain 1
abdominal cramps 1
urinary frequency 1
decreased appetite 1
sinus congestion 1
colic 1
hypocapnia 1
not coping 1
muscle rigidity 1
neuralgia 1
Circling 1
spasm 1
Inflammatory pain 1
Drug
ROS 1073
Monit 151
ascorbate 120
MAP 112
vitamin E 107
Dermatol 104
lysine 103
Cardiovasc 97
IFN-gamma 96
IL-2 92
Ethanol 84
Arsenic trioxide 73
AMC 66
CED 64
CSF 59
p75 56
Taxol 53
Glutathione 51
caffeine 47
TTC 46
CTX 45
Bortezomib 43
ICI 41
Indomethacin 40
Simvastatin 40
MRC 38
ZnO 36
Heme 36
Imatinib 34
Sorafenib 34
Glycyrrhiza 33
TAT 32
Etoposide 32
Ginseng 32
Propofol 32
EE2 31
Angiotensin II 31
NADH 30
CPT-11 28
Fluorescein 28
Adriamycin 28
NVP 27
ADR 27
Mutagen 25
Emodin 25
Emodin 25
ADM 25
Docetaxel 24
-deoxyadenosine 23
Parkin 23
Parkin 23
Vitamin E 22
ALA 21
Gefitinib 20
PFT 20
Rutin 19
CTX 19
CTX 19
Lovastatin 18
Leaf 18
3-Methyladenine 17
BH4 16
Epigallocatechin 16
Oxaliplatin 16
Gel 16
Nitric Oxide 16
Ouabain 15
Gleevec 15
CoCl2 15
CoCl2 15
Glucagon 15
Propidium 14
Phosphatidylserine 14
Photofrin 14
citric acid 14
lactose 14
CCL 13
DNase I 13
ABC 13
IFN-beta 13
Asn 12
EPA 12
Retinoic acid 12
Sodium nitroprusside 12
Fluorescein 12
Liraglutide 11
Fragment 11
Flavopiridol 11
TiO2 11
CAM 11
Bifidobacterium 11
Cilostazol 11
Nephron 10
VCR 10
Ginger 10
Albumin 10
Fipronil 10
Activin 10
Myricetin 10
Kainic acid 10
VCR 10
Pravastatin 10
Growth hormone 9
GHRP 9
Dasatinib 9
GEO 9
2-Methoxyestradiol 9
Cetuximab 9
Rosiglitazone 9
Areca 9
NBT 9
Rosuvastatin 9
MDM 9
Portal 9
G-CSF 9
Paraffin 9
Growth hormone 9
uPA 9
Fraction 9
AraC 9
ETS 9
Erlotinib 9
Silica 8
Vitamin K 8
Ulinastatin 8
G418 8
Colistin 8
TAC 8
CA-074 8
Estrogens 8
niacin 8
Herceptin 8
Rituximab 8
Tannic acid 8
Zoledronic acid 8
Lenalidomide 7
Artesunate 7
Vinorelbine 7
DEX 7
RFP 7
ROC 7
Forskolin 7
TAK 6
Fludarabine 6
Aliskiren 6
Vitamin A 6
Gelatin 6
Tacrolimus 6
Histamine 6
Finasteride 6
Pilocarpine 6
Deferasirox 6
Alanine 6
Hyperforin 6
Itraconazole 6
Asthma 6
Auranofin 6
Zoledronic acid 6
Raloxifene 6
TMS 5
more...
Enzyme
caspase-3 35750
caspase-9 4691
mitogen-activated protein kinase 3450
PARP 3345
caspase-8 3091
superoxide dismutase 1778
ERK 1219
catalase 1117
protein kinase 1071
lactate dehydrogenase 937
caspase-1 741
glutathione peroxidase 626
caspase-7 551
caspase-7 532
alanine aminotransferase 433
protein kinase C 430
proteasome 424
focal adhesion kinase 422
luciferase 410
MEK 382
aspartate aminotransferase 374
peroxidase 343
phosphatidylinositol 3-kinase 342
GSK 305
caspase-2 298
caspase-2 289
cdc2 270
caspase-6 252
AMP-activated protein kinase 243
caspase-6 231
creatine kinase 212
NADPH oxidase 206
phosphoinositide 3-kinase 194
NADPH oxidase 192
ATPase 184
TdT 180
tyrosine hydroxylase 157
glutathione S-transferase 156
AMPK 153
NO synthase 144
glutathione reductase 144
calcineurin 142
AMPK 140
MPP 136
alkaline phosphatase 135
acetylcholinesterase 126
P-glycoprotein 122
MMP 120
complex I 120
AST 119
granzyme B 118
cathepsin B 114
topoisomerase 110
topoisomerase 101
heme oxygenase 101
caspase-4 89
collagenase 88
MAP 86
caspase-4 84
endonuclease 83
IKK 82
ACS 81
reverse transcriptase 80
NOS 77
NQO1 76
cathepsin D 75
m-calpain 66
thrombin 66
mu-calpain 61
phospholipase C 60
caspase-10 60
caspase-10 59
phosphodiesterase 58
phospholipase A2 58
trypsin 56
Omi/HtrA2 55
succinate dehydrogenase 50
xanthine oxidase 50
DNase 49
RNase 47
RNase 46
cytochrome oxidase 43
renin 42
DNA ligase 41
DNA ligase 41
CAD 40
CAD 40
CAD 40
glyceraldehyde-3-phosphate dehydrogenase 39
RNA polymerase 38
MEKK1 36
APC 36
caspase-11 35
protein phosphatase 2A 35
caspase-11 35
thioredoxin reductase 33
choline acetyltransferase 32
glyceraldehyde-3-phosphate dehydrogenase 32
urokinase-type plasminogen activator 32
TAT 32
lipoxygenase 31
beta-galactosidase 31
PDK1 31
cholinesterase 30
ornithine decarboxylase 29
MMP-3 29
DCF 28
acid phosphatase 28
neutral sphingomyelinase 28
aconitase 28
ACE 27
gamma-glutamyl transpeptidase 27
monoamine oxidase 27
glyceraldehyde-3-phosphate dehydrogenase 26
glyceraldehyde-3-phosphate dehydrogenase 26
glyceraldehyde-3-phosphate dehydrogenase 26
guanylate cyclase 26
ricin 25
CaMKII 25
thymidine kinase 24
cathepsin L 24
aldehyde dehydrogenase 23
MDR 23
gamma-glutamylcysteine synthetase 23
MIP 22
tissue plasminogen activator 22
DNA polymerase 21
paraoxonase 21
sphingosine kinase 21
PKG 21
transcriptase 21
glucose-6-phosphate dehydrogenase 20
HSD 20
CPT 20
adenylate cyclase 20
matrix metalloproteinase 9 20
elastase 19
peroxiredoxin 19
transglutaminase 19
farnesyltransferase 18
lysozyme 18
farnesyltransferase 18
prostate-specific antigen 17
aldehyde dehydrogenase 17
neutrophil elastase 17
CPT 17
CD10 17
CPT 16
aldehyde dehydrogenase 16
DNA methyltransferase 16
aldehyde dehydrogenase 16
ATP synthase 16
aldehyde dehydrogenase 16
thymidylate synthase 16
diamine oxidase 16
chymotrypsin 16
neuraminidase 15
SPC 15
firefly luciferase 15
arginase 15
more...
Compound
DNA 6730
oxygen 4966
Dec 2510
MTT 2292
TNF 1552
glucose 1324
GSH 1266
GSH 1266
dUTP 1263
calcium 1090
water 1012
nitric oxide 961
cysteine 950
iodine 898
MDA 859
ATP 825
hydrogen 740
Asp 716
bromide 685
ADP-ribose 662
sodium 613
Clin 568
N-acetylcysteine 508
glutamate 459
H2O2 453
ethanol 438
alanine 406
serine 382
tyrosine 379
ADP 368
nitrogen 359
creatinine 348
urea 324
ADP 315
ADP 314
zinc 300
DDP 291
phosphate 261
iron 243
arginine 243
Hoechst 33342 240
Curcumin 239
MEK 238
galactose 222
acetate 221
acridine 213
threonine 209
Neuronal 200
Cyt 195
Adriamycin 187
ADR 186
potassium 184
cadmium 181
cAMP 179
retinoic acid 168
aldehyde 162
aldehyde 159
copper 157
NH2 155
CAT 155
CAT 155
CAT 155
sulfate 154
Resveratrol 152
NAD 146
lysine 145
THP 144
THP 144
boron 143
diacetate 141
selenium 141
Panam 140
MPP 136
Cytochrome c 136
MPP 136
fluorine 131
leucine 130
NAD 127
MTS 127
8-OHdG 124
Quercetin 117
Melatonin 115
GSSG 114
methionine 113
manganese 113
NMDA 109
PEG 107
salt 107
ethyl acetate 106
DMSO 104
nicotinamide 103
Pac 97
Cardiol 94
Cereb 94
Insulin 93
aspartic acid 91
TEM 91
AMP 90
MAP 89
His 88
silver 87
MPTP 86
CO2 85
palmitic acid 85
Phe 83
methanol 83
ACS 81
ACS 81
Retinal 81
5-FU 80
cobalt 80
PEG 80
aspartic acid 79
cGMP 78
Hematoxylin 77
aspartic acid 76
aspartic acid 76
H2S 76
ATF 74
glutamine 73
homocysteine 72
UTP 72
chalcone 72
STZ 71
nitrate 70
VP-16 70
Glutamate 69
kaempferol 67
dATP 67
Berberine 65
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 64
NADPH 62
NADPH 62
pyrrolidine 62
APAP 61
DBP 61
PGE 60
Paclitaxel 59
naphthoquinone 57
anthracene 57
pyrrolidine 56
gallic acid 56
DCB 56
pyrimidine 56
SDS 55
naphthoquinone 55
Staurosporine 55
Cer 55
DCB 55
naphthoquinone 55
naphthoquinone 55
naphthoquinone 55
hexane 55
DCB 55
naphthoquinone 55
Staurosporine 55
naphthoquinone 55
DCB 55
DCB 55
SCC 54
more...