Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.56 (
caspase-3
)
35,750
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aberrant expression of
RBM6
has been implicated in the development of human malignancies. However, the bio-function of
RBM6
in laryngocarcinoma is still almost blank. Here we identified that
RBM6
was downregulated in laryngocarcinoma tissues, as well as laryngocarcinoma cell lines. Notably, the expression level of
RBM6
was lower in laryngocarcinoma patients at stage3/4 than that in laryngocarcinoma patients at stage1/2. Upregulation of
RBM6
suppressed the proliferation of TU212 and Hep-2 cells, as shown by decreased cell viability and Ki67 level. In parallel, overexpression of
RBM6
inhibited invasion and promoted apoptosis of TU212 and Hep-2 cells, as evidenced by downregulation of MMP-2 and MMP-9 protein expression and upregulation of cleaved
caspase-3
protein expression. In vivo,
RBM6
overexpression repressed the laryngocarcinoma tumor growth. EGFR mRNA level was higher in the laryngocarcinoma tissues than that in the adjacent normal tissues. Moreover, upregulation of
RBM6
reduced the expression of EGFR, ERK and p-ERK in vitro and in vivo. Our data suggest that
RBM6
as a tumor suppressor represses the growth and progression in laryngocarcinoma.
...
PMID:RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma. 3077 16
