Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.54 (calpain 3)
 430 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
p94 16.2
CAPN3 16.2
calpain 13 16.2
calpain 3 15.8
LGMD2A 15.2
CAPN3 protein 15.2
CAPN11 15.2
nCL-2 15.0
calpain 5 14.6
CAPN9 14.6
C5orf25 14.6
ITGB1BP2 14.2
LGMD2K 14.2
castor zinc finger 1 14.2
FERM domain containing 5 14.2
LGMD2B 14.0
telethonin 13.4
CAPN8 13.4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 13.4
calpain 9 13.3
nSMase3 13.2
myopalladin 13.1
muCANP 13.0
SGCB 12.9
cardiac ankyrin repeat protein 12.8
Telethonin 12.7
dysferlin 12.7
calpain 2 12.6
MYOT 12.5
SGCA 12.5
fukutin-related protein 12.5
DYSF 12.5
GANC 12.4
RPL38 12.3
CLSTN1 12.3
PARVB 12.2
CAPN1 12.2
PINCH2 12.1
myotilin 12.1
connectin 12.1
transportin 3 12.0
caveolin 3 11.9
Fukutin-related protein 11.9
mCANP 11.9
SGCG 11.9
delta-sarcoglycan 11.9
calpain 10 11.9
TRIM32 11.7
FLNC 11.7
myospryn 11.7
AHNAK2 11.7
melusin 11.7
DARP 11.7
UNC5H2 11.6
30K) 11.6
affixin 11.5
calpastatin 11.5
polymerase I and transcript release factor 11.5
CANP 11.4
CAPN10 11.4
CARP 11.4
UBIAD1 11.4
AE4 11.3
MATK 11.3
PDLIM3 11.2
GAS7 11.2
Connectin 11.2
titin 11.2
LAMA2 11.1
GDD 11.1
p84 11.1
GMPPB 11.1
FRZB 11.1
HLA-DR beta chain 11.1
PLEC1 11.1
DNAJB6 11.0
JKTBP1 11.0
p83 11.0
calcium-activated neutral protease 11.0
AHNAK 11.0
ALDOB 11.0
KChIP4 10.9
calpain 10.9
fukutin 10.9
dystrophin-associated glycoprotein 10.8
CASZ1 10.8
POMT1 10.8
alpha tropomyosin 10.7
frizzled-related protein 10.7
calcium-activated neutral proteinase 10.6
C-terminal binding protein 1 10.6
LAGE-1 10.6
CTBP1 10.6
ETFDH 10.6
ALX1 10.6
muscle LIM protein 10.5
RPL4 10.5
TCAP 10.4
nebulin 10.4
TRIM29 10.4
TNNT1 10.4
COL6A1 10.4
VLCAD 10.3
caveolin-3 10.3
DLX2 10.2
cardiac myosin binding protein-C 10.2
sarcospan 10.2
merosin 10.2
SMCHD1 10.1
MAM 10.1
CRYBB2 10.1
transient receptor potential canonical 1 10.1
PTRF 10.1
GSTM2 10.0
SARM1 10.0
gamma-sarcoglycan 10.0
CHI3 9.9
Calpain-1 9.9
COL6A3 9.9
muscle specific 9.9
nSMase2 9.9
POMT2 9.9
myoferlin 9.9
FER 9.8
SARM 9.8
fer 9.8
TTN 9.7
GNE 9.7
periaxin 9.7
Nkx-2.5 9.7
ubiquitin-conjugating enzyme E2 9.7
SYNE1 9.6
UDP-N-acetylglucosamine 2-epimerase 9.6
p74 9.6
AMPD1 9.6
NCOR2 9.6
lactate dehydrogenase-A 9.5
PANK2 9.5
filensin 9.3
splicing factor 1 9.3
ZASP 9.3
Titin 9.2
atrogin-1 9.2
p49 9.2
FHL1 9.2
IkappaB alpha 9.1
CLP36 9.1
DRw11 9.1
LMNA 9.1
lamin A/C 9.0
ankyrin repeat protein 9.0
sarcomeric 9.0
p120GAP 9.0
McLeod syndrome 9.0
thrombospondin 2 9.0
MuRF1 9.0
NCX3 8.9
Stat2 8.9
M-cadherin 8.9
Emery-Dreifuss muscular dystrophy 8.9
more...
Disease
LGMD2J 15.6
LGMD2A 15.2
LGMD2G 15.0
LGMD2H 15.0
LGMD1E 14.9
LGMD1F 14.9
LGMD2F 14.4
LGMD2E 14.4
LGMD2D 14.3
LGMD2K 14.2
LGMD1D 14.2
LGMD2I 14.0
LGMD2B 14.0
LGMD1G 13.6
LGMD1C 13.5
LGMD2C 13.3
limb-girdle muscular dystrophy 13.3
LGMD1A 13.2
LGMD1B 13.2
IS2 12.2
Disuse atrophy 11.0
IS1 10.9
MDC1A 10.0
Avian infectious bronchitis 9.9
muscular dystrophy 9.9
McLeod syndrome 9.5
CMD 9.0
Fukuyama congenital muscular dystrophy 9.0
CMD 9.0
Emery-Dreifuss muscular dystrophy 8.9
camptocormia 8.9
Maedi 8.7
hereditary fructose intolerance 8.5
diabetic cataract 8.4
neuromuscular disorder 8.1
Ullrich 7.9
FMD 7.7
myopathy 7.6
muscular atrophy 7.6
choroid plexus papilloma 7.4
blue nevus 7.4
MDM 7.3
benign nevi 7.3
Diaphragm 7.2
protein deficiency 7.1
wasting 7.0
foot drop 6.9
tyrosinemia 6.9
familial hemophagocytic lymphohistiocytosis 6.9
Duchenne muscular dystrophy 6.9
myositis 6.8
AMD 6.7
spastic paraplegia 6.7
lipoatrophy 6.6
dysplastic nevi 6.5
galactosemia 6.5
lentigo 6.5
MDI 6.4
IBM 6.4
DMS 6.2
BMD 6.1
mitochondrial myopathy 6.1
keratoconjunctivitis 5.8
EMD 5.7
DES 5.7
ischemic cardiomyopathy 5.5
right bundle branch block 5.3
dermatomyositis 5.1
lipodystrophy 5.1
genetic disorder 5.0
motor neuron disease 4.7
dilated cardiomyopathy 4.6
metastatic melanoma 4.6
polymyositis 4.5
vitiligo 4.4
Lyme disease 4.4
papillary thyroid cancer 4.2
transitional cell carcinoma 4.2
toxic shock syndrome 4.1
PML 4.1
DM1 4.1
cataract 3.9
brain atrophy 3.9
minimal residual disease 3.9
atrioventricular block 3.8
cardiomyopathy 3.8
SDS 3.6
rare disease 3.6
Mycoplasma 3.3
hypertrophic cardiomyopathy 3.3
Infections 3.2
sepsis 2.8
vaccinia 2.8
type 2 diabetes 2.7
melanoma 2.7
sepsis 2.6
brain tumor 2.6
Evans 2.6
aggressiveness 2.6
tetanus 2.6
celiac disease 2.5
parkinsonism 2.4
Leukemia 2.3
liver cancer 2.3
mental retardation 2.2
mental retardation 2.2
mole 2.1
gastric cancer 2.0
chronic disease 2.0
amyotrophic lateral sclerosis 2.0
mole 1.8
confusion 1.8
SEM 1.6
cornea 1.6
sarcoma 1.5
malnutrition 1.4
fits 1.2
epilepsy 1.2
hepatocellular carcinoma 1.1
Infection 1.0
hepatitis B 1.0
tumor progression 0.9
leukemia 0.7
plaque 0.5
Alzheimer's disease 0.4
diabetes 0.4
tumor growth 0.3
carcinogenesis 0.2
heart failure 0.0
West 0.0
atherosclerosis -0.1
ischemia -0.3
metastases -0.5
obesity -0.8
tumor -0.9
stroke -1.0
cancer -1.1
hypertension -1.2
Symptom
Tenderness 7.6
syncopal episodes 7.2
weakness 6.5
abnormal gait 6.0
myalgia 5.1
cachexia 4.7
chills 4.1
starvation 3.2
anorexia 2.4
dyspnea 2.4
fatigue 0.5
anesthesia -0.6
pain -1.8
Drug
MDM 7.5
AMC 6.0
PTC 5.4
DMI 5.1
CDP 5.0
CaCl2 3.5
CaCl2 3.5
CaCl2 3.5
ENT 3.1
IFN-gamma 2.9
caffeine 2.8
IL-2 2.3
MAP 2.2
NADH 1.8
lysine 1.3
Cardiovasc -1.4
Enzyme
calpain 3 16.2
calpain 3 16.2
calpain 5 14.6
calpain 9 13.2
calpain 10 12.5
mu-calpain 11.7
m-calpain 11.6
UDP-N-acetylglucosamine 2-epimerase 10.4
actinidin 9.0
p80 7.1
neutral sphingomyelinase 6.8
acyl-CoA dehydrogenase 6.6
cathepsin B 6.5
phosphorylase kinase 6.4
p100 6.4
creatine kinase 6.4
cathepsin L 6.2
lysyl oxidase 5.9
CaMKII 5.8
PGM 5.7
acyl-CoA dehydrogenase 5.7
cathepsin G 5.4
DCF 5.2
proteasome 5.2
PDK1 5.0
myosin light chain kinase 4.8
firefly luciferase 4.7
papain 4.5
enolase 4.3
cathepsin D 4.2
chitinase 4.1
glutamate dehydrogenase 4.1
glutamate dehydrogenase 4.1
glutamate dehydrogenase 4.1
IKK 3.9
deaminase 3.9
phosphoinositide 3-kinase 3.7
glyceraldehyde-3-phosphate dehydrogenase 3.5
beta-galactosidase 3.3
MAP 3.3
glucose-6-phosphate dehydrogenase 3.2
cdc2 3.2
calcineurin 3.1
lipoxygenase 3.1
transcriptase 3.0
reverse transcriptase 2.8
chymotrypsin 2.8
focal adhesion kinase 2.8
phosphatidylinositol 3-kinase 2.7
glutathione S-transferase 2.7
caspase-3 2.6
acid phosphatase 2.5
trypsin 2.4
neuraminidase 2.4
MEK 2.0
collagenase 2.0
phospholipase C 2.0
protein kinase 1.9
peroxidase 1.8
RNA polymerase 1.1
luciferase 1.0
mitogen-activated protein kinase 0.6
superoxide dismutase 0.3
ATPase 0.2
Compound
TCAP 10.3
Emery 8.6
MAK 8.5
DMD 8.0
E-64 7.9
Carnosine 7.2
3-methylhistidine 6.6
Polypeptide 6.5
Pima 6.3
Creatine 6.1
Mendel 6.1
Ubiquitin 5.8
DES 5.7
DMS 5.5
CDP 5.5
TAP 5.5
MSM 5.3
DMI 5.1
DMI 5.1
HgCl2 5.1
L-leucine 4.9
NTA 4.9
COS 4.9
Trypsin 4.5
cysteine 4.4
calcium 4.3
Tyrosine 4.2
Estrogen 4.0
TPA 3.9
Cyclosporine 3.9
TPA 3.7
CaCl2 3.5
Heparin 3.5
SDS 3.5
DEAE 3.3
MAP 3.0
Estrogen 2.8
aspartic acid 2.8
aspartic acid 2.8
caffeine 2.8
serine 2.8
aspartic acid 2.7
tyrosine 2.6
aspartic acid 2.5
leucine 2.3
glutamic acid 2.2
Optimal 2.1
Asp 2.1
His 1.9
methionine 1.9
NADH 1.8
NH2 1.7
alanine 1.6
retinoic acid 1.6
Phe 1.5
ATP 1.5
EDTA 1.5
EDTA 1.5
Insulin 1.4
TNF 1.3
nickel 1.3
DNA 1.1
lysine 0.9
AMP 0.8
threonine 0.8
nitric oxide 0.6
Dec 0.4
sulfate 0.4
salt 0.4
creatinine 0.3
urea 0.2
Clin 0.0
nitrogen -0.1
zinc -0.3
arginine -0.4
glucose -0.4
acetate -0.7
sodium -0.9
oxygen -1.3
hydrogen -1.5
Cardiol -1.7
water -3.2