Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.54 (
calpain 3
)
430
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There are two classes of an intracellular 'modulator protease', calpain: ubiquitous and tissue-specific.
p94
/
calpain 3
is an example of the latter, predominantly expressed in muscle. A defect in the
p94
gene causes muscular dystrophy. Here we report that human and mouse
p94
genes have a possible novel alternative promoter expressing
p94
variants in all tissues examined including human lens epithelial cells. The possible promoter region and the following novel exons overlap the 3' region of the
neutral alpha-glucosidase C
gene. Unlike
p94
, the novel
p94
variants expressed in COS7 cells do not undergo rapid autolysis, suggesting basic functions different from
p94
.
...
PMID:Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. 1467 85
