Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ICE 12.3
ILPIP 12.3
CMH1 12.3
DAGD 12.3
Ly6/PLAUR domain-containing protein 6 12.3
leucine-rich repeat-containing 3 12.3
caspase and RIP adapter with death domain 12.3
toll-like receptor adaptor molecule 2 12.3
ICEBERG 11.8
CARD12 11.6
PYPAF2 11.6
IPAF 11.4
pyrin domain containing 1 11.4
apoptosis-associated speck-like protein containing a CARD 11.4
IGLL3 11.3
GIG4 11.3
guanylate binding protein 4 11.3
peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor 11.3
Ras-related protein Rab-37 11.3
NLRP13 11.3
transmembrane protein 176B 11.3
USP50 11.3
Tripartite motif-containing protein 31 11.3
NLRC4 11.3
gasdermin D 11.2
GSDMD 11.2
NALP1 11.1
NLRP3 protein 11.1
AIM2 11.1
NLRP6 11.0
NLRP1 10.9
NIMA-related kinase 7 10.9
PYPAF7 10.9
NALP2 10.9
ICH-2 10.8
HIPPI 10.8
AIM2 protein 10.8
NLRP3 10.8
NEK7 10.8
protease E) 10.7
CAGE1 10.7
RAB39A 10.7
NLRP11 10.7
DDX19A 10.7
cPOP2 10.7
NLRP1 protein 10.7
gasdermin 10.7
pyrin 10.7
Caspase-1 10.6
ASC 10.5
PYPAF3 10.5
Chemokine (C-C motif) ligand 3 10.3
NLR family, pyrin domain containing 3 10.3
NLRP10 10.2
CMH-1 10.1
CPP32 10.1
IL-18 10.0
POP3 10.0
IL-1F7 10.0
TNFRSF1A-associated via death domain 10.0
EIF-5A 10.0
NALP3 10.0
CARD8 9.9
leucine-rich-repeat protein 9.9
CASP1 9.9
CASP-1 9.9
NLRP8 9.7
ASC2 9.7
TNF receptor-associated factor 4 9.7
ICERE-1 9.7
potassium inwardly-rectifying channel 9.7
Lysophosphatidic acid receptor 1 9.7
NLRP12 9.7
TXNIP 9.7
ASC-1 9.6
ICH-1L 9.6
APIP 9.6
ICH3 9.6
IL-1F6 9.6
CIAS1 9.5
more...
Disease
CMH1 12.3
Oral pemphigus vulgaris 11.3
Chronic skin disease 10.7
Non-bacterial prostatitis 10.7
POF4 10.3
Alcoholic liver damage 10.0
Acute glaucoma 8.6
ICE syndrome 8.6
Muckle-Wells syndrome 8.5
Mevalonate kinase deficiency 8.4
NOMID 8.3
Pulmonary fat embolism 8.2
Dissecting aortic aneurysm 8.2
Vaccinia virus infection 8.2
NOD 8.1
Gouty arthritis 7.9
MYP3 7.9
Macular corneal dystrophy 7.8
Therapy-related myelodysplastic syndrome 7.5
Sepsis-associated encephalopathy 7.4
DFNA5 7.4
CINCA syndrome 7.3
malignant myeloma 7.2
gouty nephropathy 7.2
cowpox 7.2
Geographic atrophy 7.1
CPS deficiency 7.1
WTS 6.9
Parvovirus infection 6.9
Aortic atherosclerosis 6.9
Pulmonary eosinophilia 6.8
rhabdoid tumor of the kidney 6.8
Leishmania braziliensis infection 6.8
Viral myocarditis 6.7
familial Mediterranean fever 6.6
Diabetic encephalopathy 6.6
bacterial dysentery 6.6
bacillary dysentery 6.6
Hereditary tyrosinemia type I 6.5
Neonatal infection 6.3
West Nile encephalitis 6.1
placental disorders 6.1
Crescentic glomerulonephritis 6.1
Histoplasma capsulatum infection 6.1
FCU 6.1
Influenza A virus infection 6.1
Apical periodontitis 6.1
trichophytosis 6.0
gout 6.0
Intestinal ischemia 6.0
Critically Ill 6.0
Streptococcus pneumoniae meningitis 6.0
favus 5.9
Klebsiella pneumoniae infection 5.9
Lumbar disc herniation 5.9
Aspergillus fumigatus infection 5.9
Submandibular gland 5.8
Parasitic infection 5.8
vascular ischemia 5.8
anthrax 5.7
Prostate tumor 5.7
Irritant contact dermatitis 5.7
PAPA 5.6
cough variant asthma 5.6
Middle cerebral artery occlusion 5.6
Candida sepsis 5.6
maple syrup urine disease 5.6
monocytic leukemia 5.6
endotoxic shock 5.5
diabetic cardiomyopathy 5.5
Burkitt-like lymphoma 5.5
Pulmonary infiltrates 5.5
Chronic inflammatory demyelinating polyradiculoneuropathy 5.5
Prosthetic valve endocarditis 5.5
AML progression 5.4
dental abscess 5.4
Oral infection 5.4
closed angle glaucoma 5.3
Diarrheal disease 5.3
DSS 5.3
more...
Symptom
Chronic pelvic pain syndrome 7.4
localized erythema 7.4
General symptoms 6.4
peri-menopausal 4.8
male subfertility 4.3
dry eye 3.5
hyperoxia 3.1
despair 2.7
dry skin 2.3
emaciation 2.3
chills 2.2
abnormal gait 2.2
collapse 2.1
memory loss 2.1
arthralgia 1.8
splenomegaly 1.6
hypothermia 1.5
starvation 1.5
respiratory distress 1.5
chorea 1.3
tense 1.2
functional recovery 1.2
exhaustion 1.2
acute stress 1.1
asthenia 0.9
cachexia 0.8
polyuria 0.7
flushing 0.7
diarrhea 0.7
myalgia 0.6
erythema 0.6
anorexia 0.6
cerebellar ataxia 0.5
acidity 0.4
nausea 0.4
acute pain 0.4
pelvic pain 0.3
apathy 0.3
overweight 0.2
distraction 0.1
fatigue 0.1
nausea and vomiting 0.1
vomiting -0.1
seizures -0.1
pain -0.1
headache -0.1
lethargy -0.2
hepatomegaly -0.2
cough -0.2
back pain -0.3
ataxia -0.6
dystonia -0.7
syncope -0.9
dyspnea -0.9
analgesia -0.9
constipation -1.0
abdominal pain -1.0
Ill -1.1
sleepiness -1.3
anesthesia -1.4
chest pain -1.8
angina -2.1
discomfort -2.1
discomfort -2.3
Drug
Mifobate 12.3
Talabostat 10.5
Bv2 9.8
Lexatumumab 9.7
CED 9.5
CA-074 8.5
Platonin 8.4
Rilonacept 8.3
Atractylodes rhizome 8.1
Ferric ammonium citrate 7.9
Roferon A 7.9
Hirudoid 7.5
Adenosine Monophosphate 7.4
Irofulven 7.4
Anakinra 7.3
Peanut oil 7.2
Interferon alfa-2a 6.9
Amlexanox 6.8
Tenidap 6.5
Butaprost 6.4
Tipifarnib 6.2
IL-1ra 6.1
AMC 6.0
Gold sodium thiomalate 6.0
Lipitor 5.9
3-Methyladenine 5.9
Batimastat 5.8
Batimastat 5.8
Immune globulin 5.7
Glybenclamide 5.7
Paliperidone 5.6
Lipitor 5.5
Lipitor 5.5
Auranofin 5.5
Red ginseng 5.4
Pirfenidone 5.4
Idebenone 5.4
Pepstatin 5.4
Clodronate 5.3
Zevalin 5.3
Propidium 5.3
Rhubarb 5.3
Aliskiren 5.3
ROS 5.2
Saha 5.2
Vinpocetine 5.1
Rebamipide 5.1
Tianeptine 5.0
Flavopiridol 4.6
Idarubicin 4.6
Rifaximin 4.6
Tocilizumab 4.6
Rutin 4.5
Epigallocatechin 4.5
IFN-beta 4.3
Compound 9 4.3
Lactase 4.2
Etoposide 4.2
Emodin 4.1
PPA 4.1
Silica gel 4.1
DEX 4.1
Kainic acid 4.0
Mycophenolic acid 3.9
G-CSF 3.9
Glycyrrhiza 3.8
Parkin 3.8
Parkin 3.8
Tannic acid 3.7
Olive oil 3.7
Rosiglitazone 3.6
Cilostazol 3.6
Ginseng 3.6
Propofol 3.6
Aminoguanidine 3.6
IFN-gamma 3.6
Rolipram 3.6
CCL 3.6
Liraglutide 3.5
Adenosine triphosphate 3.5
more...
Enzyme
caspase-1 12.3
caspase-5 11.7
caspase-11 11.5
caspase-5 11.5
caspase-11 11.4
proteinase A 10.6
caspase-4 10.6
caspase-4 10.4
thermomycolase 9.5
meprin B 9.4
Pla 9.0
caspase-6 9.0
adenain 8.7
caspase-6 8.7
caspase-2 8.6
caspase-2 8.6
caspase-10 8.5
caspase-10 8.5
D-cysteine desulfhydrase 8.3
NS protease 8.3
caspase-7 8.2
caspase-7 8.0
streptomycin adenylyltransferase 8.0
streptopain 7.7
caspase-8 7.5
granzyme M 7.4
cathepsin V 7.3
alpha-lytic protease 7.1
cathepsin B 6.9
aspartase 6.9
granzyme K 6.9
cholesterol 25-hydroxylase 6.8
mevalonate kinase 6.7
caspase-3 6.7
deoxyhypusine hydroxylase 6.3
serralysin 6.2
legumain 6.0
TSP-1 5.9
apyrase 5.7
caspase-9 5.7
granzyme B 5.6
RGP 5.5
proteinase-3 5.5
PARP 5.4
xyloglucan endotransglycosylase 5.4
phosphoserine phosphatase 5.2
DNase II 5.1
macrophage elastase 5.1
cathepsin X 5.1
ATP diphosphohydrolase 5.0
deoxyhypusine synthase 5.0
pseudouridine synthase 5.0
nucleoside diphosphokinase 5.0
3C protease 5.0
separase 4.9
Omi/HtrA2 4.9
proteinase A 4.8
HK2 4.8
meprin 4.8
triose-phosphate isomerase 4.8
IKK 4.7
NADPH oxidase 4.7
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.7
TdT 4.6
NADPH oxidase 4.6
AMPK 4.5
phosphatidylethanolamine N-methyltransferase 4.5
fatty acid desaturase 4.4
clostripain 4.4
cathepsin S 4.3
cathepsin G 4.3
C3b inactivator 4.3
SpeB 4.2
cathepsin L 4.2
conjugase 4.2
fumarylacetoacetate hydrolase 4.1
LIS 4.1
MPP 4.0
thermolysin 4.0
AMP-activated protein kinase 4.0
more...
Compound
Ginsenoside Rf 10.7
ASC 10.5
2-methyl-6-undecylpiperidine 10.3
Chelidonic acid 10.3
Theasinensin A 10.0
5-Methoxytryptophan 9.7
Nodakenin 9.7
Cucurbitacin D 9.1
CMK 8.9
2-hydroxy-1-propanesulfonic acid 8.8
3,4-pyridinedicarboxylic acid 8.8
1-heptadecene 8.4
Dracorhodin 8.3
Wedelolactone 8.3
Rhaponticin 8.2
Ruscogenin 8.1
Nigericin 7.9
Gedunin 7.8
Micheliolide 7.8
Micheliolide 7.8
Menthone 7.8
DCB 7.6
DCB 7.6
4-phenyl-2-butanone 7.5
LLY 7.5
Sodium hydrosulfide 7.5
Propantheline 7.4
Eudesmol 7.4
DCB 7.4
Mauve 7.4
Androstenediol 7.4
Diisononyl phthalate 7.4
N-acetyltryptophan 7.4
4-phenyl-2-butanone 7.4
Gentiopicroside 7.4
Acacetin 7.3
Aluminum hydroxide 7.3
Dihydromyricetin 7.3
Purpurin 7.3
Merbarone 7.3
Loganin 7.3
Physcion 7.3
Chrysophanol 7.2
Geranylgeraniol 7.1
Stearidonic acid 7.1
DCB 7.1
Chrysophanol 7.1
27-Hydroxycholesterol 7.1
Sinigrin 7.1
DCB 7.0
Aucubin 6.9
TPCK 6.9
AS-101 6.9
TKB 6.9
THP 6.9
THP 6.8
AICA-riboside 6.8
Isoorientin 6.7
cinnamyl acetate 6.6
Pristimerin 6.6
Pristimerin 6.6
Pristimerin 6.6
Pristimerin 6.6
IVE 6.6
Fluocinolone acetonide 6.6
Ziram 6.6
14,15-DHET 6.5
Pulegone 6.5
iodic acid 6.5
T 12 6.5
Gadolinium chloride 6.4
EGT 6.4
Pelargonidin 6.4
L-chicoric acid 6.4
Harmine 6.4
Triphosphate 6.4
Liquiritigenin 6.3
10-Hydroxycamptothecin 6.3
Alum 6.3
Garcinol 6.2
more...