Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.4.22.36 (caspase-1)
6,285 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein NLRP3 1473 IL-18 1252 ICE 1052 cytokine 932 ASC 683 caspase-3 679 pyrin 560 Mol 445 Caspase-1 422 IL-1 421 lipopolysaccharide 410 Sep 369 NOD 353 IL-6 349 ATP 346 TNF 344 LPS 335 AIM2 275 tumor necrosis factor 258 caspase-8 248 THP 240 NLRC4 231 TLR4 226 Bcl-2 226 Fas 213 CPP32 165 IFN 156 adaptor protein 145 ROS 142 cysteine protease 141 gasdermin D 136 interferon 131 interleukin-18 126 p53 123 P2X7 113 NLRP1 112 PARP 110 apoptosis-associated speck-like protein containing a CARD 110 insulin 104 AII 103 p38 103 NALP3 102 cytochrome c 101 p65 100 cathepsin B 99 TLR2 95 CD4 94 IL-10 93 IL-8 93 poly(ADP-ribose) polymerase 93 MyD88 87 MAPK 84 CED 81 lactate dehydrogenase 78 caspase-9 78 Cytokine 77 IL-1 beta 77 interacting protein 75 inducible nitric oxide synthase 75 IL-17 71 bcl-2 70 TNF-alpha 69 IFN-gamma 68 p20 66 JNK 66 IL-33 65 Fas ligand 63 endoplasmic reticulum 61 p10 61 CD95 58 chemokine 57 superoxide dismutase 56 interferon-gamma 56 gasdermin 55 GSDMD 54 CMK 53 myeloperoxidase 52 gut 51 collagen 51 mast cell 51 more...

Disease cancer 383 NOD 353 tumor 272 sepsis 139 sepsis 137 diabetes 136 atherosclerosis 124 ischemia 122 Alzheimer's disease 120 infectious diseases 108 obesity 92 colitis 86 virus infection 85 bacterial infection 80 stroke 80 type 2 diabetes 72 cold 71 leukemia 70 arthritis 66 Infection 65 gout 65 tumorigenesis 63 rheumatoid arthritis 61 pneumonia 59 asthma 57 inflammatory bowel disease 55 peritonitis 54 HIV 54 Mycobacterium 53 Legionella 51 tuberculosis 51 hepatocellular carcinoma 50 multiple sclerosis 49 cerebral ischemia 49 Parkinson's disease 49 melanoma 48 carcinoma 47 depression 47 influenza 43 anthrax 43 breast cancer 42 lymphoma 41 tumor growth 40 GSH 39 cardiovascular disease 38 Yersinia 38 familial Mediterranean fever 36 cognitive impairment 36 amyotrophic lateral sclerosis 34 neuroblastoma 34 myocardial infarction 34 heart failure 34 atopic dermatitis 32 Blocking 32 psoriasis 32 Shigella 32 B-cell lymphoma 32 chronic obstructive pulmonary disease 30 systemic lupus erythematosus 30 AIDS 29 colorectal cancer 29 periodontitis 28 Crohn's disease 27 myocardial ischemia 27 carcinogenesis 27 hypertension 27 Chlamydia 26 salmonellosis 26 immunodeficiency 26 dermatitis 26 hyperglycemia 25 ulcerative colitis 25 Hodgkin's disease 25 liver disease 24 renal disease 24 encephalomyelitis 24 acute myeloid leukemia 24 cowpox 24 metabolic syndrome 23 tumor progression 23 more...

Symptom pain 47 collapse 25 diarrhea 18 seizures 15 starvation 14 fatigue 11 respiratory distress 11 hypothermia 10 headache 10 hyperoxia 9 anesthesia 8 splenomegaly 6 nausea 6 vomiting 6 exhaustion 6 dry eye 6 overweight 6 functional recovery 6 arthralgia 5 acidity 4 cough 4 erythema 4 anorexia 4 chills 4 abdominal pain 3 dyspnea 3 memory loss 3 analgesia 3 ataxia 2 nausea and vomiting 2 distraction 2 back pain 2 acute stress 2 cachexia 2 myalgia 2 despair 2 flushing 2 discomfort 1 asthenia 1 chest pain 1 chorea 1 hepatomegaly 1 apathy 1 constipation 1 male subfertility 1 abnormal gait 1 lethargy 1 discomfort 1 dry skin 1 sleepiness 1 peri-menopausal 1 syncope 1 dystonia 1 emaciation 1 angina 1 tense 1 pelvic pain 1 polyuria 1 cerebellar ataxia 1 Ill 1 localized erythema 1 General symptoms 1 Chronic pelvic pain syndrome 1 acute pain 1

Drug ROS 142 CED 81 IFN-gamma 68 Dermatol 46 CSF 25 IL-2 20 Cardiovasc 20 IL-1ra 19 Monit 18 G-CSF 15 AMC 15 lysine 15 IFN-beta 12 CA-074 8 Anakinra 8 MAP 7 Heme 6 Parkin 5 Propofol 5 ampicillin 5 p75 5 Taxol 5 Parkin 5 Ethanol 5 Gel 5 CTX 4 Ginseng 4 Glycyrrhiza 4 TTC 4 Asthma 4 CPT-11 4 Etoposide 4 Silica 4 vitamin E 4 Alliance 4 ascorbate 4 Asn 4 Nitric Oxide 4 DNase I 3 Auranofin 3 Spectrum 3 Bifidobacterium 3 FAD 3 CCL 3 Glutathione 3 DEX 3 lactose 3 Indomethacin 3 ZnO 3 Histamine 3 Rutin 3 Leaf 3 Biopolymers 2 CaCl2 2 Paraffin 2 Emodin 2 AZT 2 Fluorescein 2 CaCl2 2 3-Methyladenine 2 Kainic acid 2 Arsenic trioxide 2 Pirfenidone 2 Tocilizumab 2 PPA 2 Rituximab 2 -deoxyadenosine 2 Aliskiren 2 Alanine 2 Simvastatin 2 BH4 2 Propidium 2 AZT 2 ABC 2 CTX 2 CTX 2 Epigallocatechin 2 ACT 2 CAM 2 Bv2 2 more...

Enzyme caspase-1 6285 caspase-3 741 caspase-8 245 mitogen-activated protein kinase 232 caspase-11 194 caspase-11 193 PARP 116 caspase-4 110 caspase-4 108 cathepsin B 99 Pla 90 lactate dehydrogenase 82 proteinase A 81 superoxide dismutase 80 caspase-9 76 caspase-2 64 protein kinase 63 caspase-2 60 peroxidase 58 caspase-7 54 NADPH oxidase 53 NADPH oxidase 52 proteasome 51 caspase-5 51 caspase-6 49 caspase-5 48 ERK 46 luciferase 46 caspase-7 46 alanine aminotransferase 44 AMP-activated protein kinase 41 catalase 41 caspase-6 39 granzyme B 32 focal adhesion kinase 29 AMPK 29 aspartate aminotransferase 28 AMPK 28 IKK 25 trypsin 24 ATPase 23 reverse transcriptase 21 topoisomerase 21 ACS 20 topoisomerase 20 NO synthase 19 protein kinase C 19 apyrase 16 xanthine oxidase 15 AST 14 elastase 14 caspase-10 13 caspase-10 13 MEK 13 glutathione S-transferase 12 ACE 11 endonuclease 11 tyrosine hydroxylase 11 calcineurin 11 neutrophil elastase 11 thrombin 11 cathepsin D 10 glutathione peroxidase 10 TSP-1 10 chymotrypsin 10 RNA polymerase 10 MIP 9 creatine kinase 9 pepsin 9 TdT 9 alkaline phosphatase 9 NQO1 8 RNase 8 mevalonate kinase 8 RNase 8 collagenase 8 papain 8 cathepsin G 7 complex I 7 adenylate cyclase 7 more...

Compound ASC 683 DNA 602 oxygen 532 Dec 394 ATP 346 TNF 344 THP 240 THP 240 leucine 230 cysteine 228 Asp 190 glucose 173 calcium 149 water 135 Clin 129 potassium 127 alanine 120 sodium 109 nitric oxide 106 serine 95 tyrosine 82 acetate 71 sulfate 70 aldehyde 54 aldehyde 54 CMK 53 dUTP 49 N-acetylcysteine 47 hydrogen 44 GSH 40 GSH 40 nitrogen 37 phosphate 37 glutamate 33 ethanol 32 zinc 31 iodine 29 lysine 28 creatinine 28 MTT 28 arginine 27 salt 27 MDA 26 Cardiol 24 aspartic acid 24 ADP-ribose 24 His 23 aspartic acid 22 ADP 22 ADP 22 aspartic acid 22 aspartic acid 22 cAMP 22 iron 22 ADP 22 urea 21 methionine 21 Phe 21 aluminum 20 AMP 20 ACS 20 ACS 20 DBP 19 DCB 19 proline 19 DCB 19 DCB 19 H2O2 19 DCB 19 DCB 19 palmitic acid 18 CO2 18 NH2 18 threonine 18 silver 16 SDS 16 NADPH 15 copper 15 Neuronal 15 NADPH 15 more...

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