Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:3.4.22.36 (caspase-1)
6,285 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein NLRP3 1473 IL-18 1252 ICE 1052 cytokine 932 ASC 683 caspase-3 679 pyrin 560 Mol 445 Caspase-1 422 IL-1 421 lipopolysaccharide 410 Sep 369 NOD 353 IL-6 349 ATP 346 TNF 344 LPS 335 AIM2 275 tumor necrosis factor 258 caspase-8 248 THP 240 NLRC4 231 Bcl-2 226 TLR4 226 Fas 213 CPP32 165 IFN 156 adaptor protein 145 ROS 142 cysteine protease 141 gasdermin D 136 interferon 131 interleukin-18 126 p53 123 P2X7 113 NLRP1 112 apoptosis-associated speck-like protein containing a CARD 110 PARP 110 insulin 104 p38 103 more...

Disease cancer 383 NOD 353 tumor 272 sepsis 139 sepsis 137 diabetes 136 atherosclerosis 124 ischemia 122 Alzheimer's disease 120 infectious diseases 108 obesity 92 colitis 86 virus infection 85 stroke 80 bacterial infection 80 type 2 diabetes 72 cold 71 leukemia 70 arthritis 66 Infection 65 gout 65 tumorigenesis 63 rheumatoid arthritis 61 pneumonia 59 asthma 57 inflammatory bowel disease 55 HIV 54 peritonitis 54 Mycobacterium 53 Legionella 51 tuberculosis 51 hepatocellular carcinoma 50 multiple sclerosis 49 cerebral ischemia 49 Parkinson's disease 49 melanoma 48 depression 47 carcinoma 47 influenza 43 anthrax 43 more...

Symptom pain 47 collapse 25 diarrhea 18 seizures 15 starvation 14 fatigue 11 respiratory distress 11 hypothermia 10 headache 10 hyperoxia 9 anesthesia 8 splenomegaly 6 functional recovery 6 nausea 6 overweight 6 dry eye 6 vomiting 6 exhaustion 6 arthralgia 5 acidity 4 erythema 4 anorexia 4 cough 4 chills 4 memory loss 3 dyspnea 3 abdominal pain 3 analgesia 3 flushing 2 nausea and vomiting 2 despair 2 distraction 2 back pain 2 ataxia 2 cachexia 2 acute stress 2 myalgia 2 discomfort 1 asthenia 1 chest pain 1 more...

Drug ROS 142 CED 81 IFN-gamma 68 Dermatol 46 CSF 25 Cardiovasc 20 IL-2 20 IL-1ra 19 Monit 18 AMC 15 G-CSF 15 lysine 15 IFN-beta 12 CA-074 8 Anakinra 8 MAP 7 Heme 6 ampicillin 5 Taxol 5 Parkin 5 Gel 5 Propofol 5 p75 5 Ethanol 5 Parkin 5 CPT-11 4 Ginseng 4 Alliance 4 Nitric Oxide 4 ascorbate 4 Etoposide 4 Asn 4 CTX 4 Silica 4 Glycyrrhiza 4 TTC 4 vitamin E 4 Asthma 4 FAD 3 Indomethacin 3 more...

Enzyme caspase-1 6285 caspase-3 741 caspase-8 245 mitogen-activated protein kinase 232 caspase-11 194 caspase-11 193 PARP 116 caspase-4 110 caspase-4 108 cathepsin B 99 Pla 90 lactate dehydrogenase 82 proteinase A 81 superoxide dismutase 80 caspase-9 76 caspase-2 64 protein kinase 63 caspase-2 60 peroxidase 58 caspase-7 54 NADPH oxidase 53 NADPH oxidase 52 proteasome 51 caspase-5 51 caspase-6 49 caspase-5 48 caspase-7 46 ERK 46 luciferase 46 alanine aminotransferase 44 AMP-activated protein kinase 41 catalase 41 caspase-6 39 granzyme B 32 AMPK 29 focal adhesion kinase 29 AMPK 28 aspartate aminotransferase 28 IKK 25 trypsin 24 more...

Compound ASC 683 DNA 602 oxygen 532 Dec 394 ATP 346 TNF 344 THP 240 THP 240 leucine 230 cysteine 228 Asp 190 glucose 173 calcium 149 water 135 Clin 129 potassium 127 alanine 120 sodium 109 nitric oxide 106 serine 95 tyrosine 82 acetate 71 sulfate 70 aldehyde 54 aldehyde 54 CMK 53 dUTP 49 N-acetylcysteine 47 hydrogen 44 GSH 40 GSH 40 nitrogen 37 phosphate 37 glutamate 33 ethanol 32 zinc 31 iodine 29 MTT 28 creatinine 28 lysine 28 more...

---