Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NLRP3 1473
IL-18 1252
ICE 1052
cytokine 932
ASC 683
caspase-3 679
pyrin 560
Mol 445
Caspase-1 422
IL-1 421
lipopolysaccharide 410
Sep 369
NOD 353
IL-6 349
ATP 346
TNF 344
LPS 335
AIM2 275
tumor necrosis factor 258
caspase-8 248
more...
Disease
cancer 383
NOD 353
tumor 272
sepsis 139
sepsis 137
diabetes 136
atherosclerosis 124
ischemia 122
Alzheimer's disease 120
infectious diseases 108
obesity 92
colitis 86
virus infection 85
stroke 80
bacterial infection 80
type 2 diabetes 72
cold 71
leukemia 70
arthritis 66
Infection 65
more...
Symptom
pain 47
collapse 25
diarrhea 18
seizures 15
starvation 14
fatigue 11
respiratory distress 11
headache 10
hypothermia 10
hyperoxia 9
anesthesia 8
vomiting 6
splenomegaly 6
functional recovery 6
nausea 6
dry eye 6
overweight 6
exhaustion 6
arthralgia 5
cough 4
more...
Drug
ROS 142
CED 81
IFN-gamma 68
Dermatol 46
CSF 25
IL-2 20
Cardiovasc 20
IL-1ra 19
Monit 18
lysine 15
AMC 15
G-CSF 15
IFN-beta 12
CA-074 8
Anakinra 8
MAP 7
Heme 6
p75 5
ampicillin 5
Ethanol 5
more...
Enzyme
caspase-1 6285
caspase-3 741
caspase-8 245
mitogen-activated protein kinase 232
caspase-11 194
caspase-11 193
PARP 116
caspase-4 110
caspase-4 108
cathepsin B 99
Pla 90
lactate dehydrogenase 82
proteinase A 81
superoxide dismutase 80
caspase-9 76
caspase-2 64
protein kinase 63
caspase-2 60
peroxidase 58
caspase-7 54
more...
Compound
ASC 683
DNA 602
oxygen 532
Dec 394
ATP 346
TNF 344
THP 240
THP 240
leucine 230
cysteine 228
Asp 190
glucose 173
calcium 149
water 135
Clin 129
potassium 127
alanine 120
sodium 109
nitric oxide 106
serine 95
more...