Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ILPIP 12.3
DAGD 12.3
leucine-rich repeat-containing 3 12.3
ICE 12.3
Ly6/PLAUR domain-containing protein 6 12.3
toll-like receptor adaptor molecule 2 12.3
CMH1 12.3
caspase and RIP adapter with death domain 12.3
ICEBERG 11.8
PYPAF2 11.6
CARD12 11.6
IPAF 11.4
pyrin domain containing 1 11.4
apoptosis-associated speck-like protein containing a CARD 11.4
NLRP13 11.3
transmembrane protein 176B 11.3
Ras-related protein Rab-37 11.3
USP50 11.3
IGLL3 11.3
peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor 11.3
GIG4 11.3
Tripartite motif-containing protein 31 11.3
guanylate binding protein 4 11.3
NLRC4 11.3
gasdermin D 11.2
GSDMD 11.2
NALP1 11.1
NLRP3 protein 11.1
AIM2 11.1
NLRP6 11.0
NLRP1 10.9
NIMA-related kinase 7 10.9
PYPAF7 10.9
NALP2 10.9
ICH-2 10.8
HIPPI 10.8
AIM2 protein 10.8
NLRP3 10.8
NEK7 10.8
cPOP2 10.7
NLRP11 10.7
RAB39A 10.7
CAGE1 10.7
DDX19A 10.7
protease E) 10.7
NLRP1 protein 10.7
gasdermin 10.7
pyrin 10.7
Caspase-1 10.6
ASC 10.5
PYPAF3 10.5
Chemokine (C-C motif) ligand 3 10.3
NLR family, pyrin domain containing 3 10.3
NLRP10 10.2
CMH-1 10.1
CPP32 10.1
IL-18 10.0
IL-1F7 10.0
TNFRSF1A-associated via death domain 10.0
EIF-5A 10.0
POP3 10.0
NALP3 10.0
CARD8 9.9
leucine-rich-repeat protein 9.9
CASP1 9.9
CASP-1 9.9
ASC2 9.7
Lysophosphatidic acid receptor 1 9.7
potassium inwardly-rectifying channel 9.7
NLRP8 9.7
TNF receptor-associated factor 4 9.7
ICERE-1 9.7
NLRP12 9.7
TXNIP 9.7
ASC-1 9.6
ICH-1L 9.6
APIP 9.6
ICH3 9.6
IL-1F6 9.6
CIAS1 9.5
TMS1 9.5
NLRP9 9.5
huntingtin interacting protein 1 9.5
EEA1 protein 9.5
interleukin-18 9.5
p20 9.4
RFC140 9.4
PSTPIP2 9.4
BRCC3 9.4
GBP5 9.3
Septin-2 9.3
COMMD10 9.3
neural cell adhesion molecule 2 9.3
P2X purinoceptor 7 9.3
NAIP 9.3
NLRP7 9.2
CARD-containing protein 9.2
cell death inhibiting RNA 9.1
Fas-associating protein 9.1
PN-I 9.1
myotubularin-related protein 3 9.1
Adapter protein 9.1
CMK 9.1
POP1 9.1
caspase 4 9.1
NLRP4 9.1
DEFA3 9.1
CED 9.0
NLRP2 9.0
DFF35 9.0
toll-like receptor 6 9.0
glutathione S-transferase omega 1-1 9.0
RAIDD 9.0
GBP3 9.0
NLRC3 9.0
RIP2 8.9
IL18 8.9
SIGLEC5 8.8
DHX33 8.8
IL-1F9 8.8
Pannexin-1 8.8
interleukin 18 8.7
CARD6 8.7
ORCTL3 8.7
caspase-14 8.6
Caspase-activated DNase 8.6
Friend leukemia virus integration 1 8.6
calmodulin 3 8.6
EIF3A 8.6
SFRS3 8.6
caspase 2 8.6
endosomal adaptor protein 8.5
TUBB6 8.5
MIHC 8.5
IL-18Rbeta 8.5
Interleukin-18 8.4
ABRO1 8.4
CCL4L 8.4
ETS1 protein 8.4
formin 2 8.4
p10 8.4
IFI16 8.4
ASCI 8.3
serine/threonine kinase 2 8.3
CLAN 8.3
SIPP1 8.3
DPP9 8.2
GBP2 8.2
MAP kinase kinase 3 8.2
IL-1Rrp2 8.2
P2X7 8.2
INCA 8.2
CASP-9 8.1
POP2 8.1
AG11 8.1
TMS-1 8.1
Interleukin 18 8.1
Nod1 8.1
NOD 8.1
leucine-rich repeat protein 8.1
more...
Disease
CMH1 12.3
Oral pemphigus vulgaris 11.3
Chronic skin disease 10.7
Non-bacterial prostatitis 10.7
POF4 10.3
Alcoholic liver damage 10.0
Acute glaucoma 8.6
ICE syndrome 8.6
Muckle-Wells syndrome 8.5
Mevalonate kinase deficiency 8.4
NOMID 8.3
Pulmonary fat embolism 8.2
Dissecting aortic aneurysm 8.2
Vaccinia virus infection 8.2
NOD 8.1
Gouty arthritis 7.9
MYP3 7.9
Macular corneal dystrophy 7.8
Therapy-related myelodysplastic syndrome 7.5
Sepsis-associated encephalopathy 7.4
DFNA5 7.4
CINCA syndrome 7.3
malignant myeloma 7.2
gouty nephropathy 7.2
cowpox 7.2
Geographic atrophy 7.1
CPS deficiency 7.1
WTS 6.9
Aortic atherosclerosis 6.9
Parvovirus infection 6.9
Pulmonary eosinophilia 6.8
rhabdoid tumor of the kidney 6.8
Leishmania braziliensis infection 6.8
Viral myocarditis 6.7
familial Mediterranean fever 6.6
Diabetic encephalopathy 6.6
bacterial dysentery 6.6
bacillary dysentery 6.6
Hereditary tyrosinemia type I 6.5
Neonatal infection 6.3
West Nile encephalitis 6.1
placental disorders 6.1
Histoplasma capsulatum infection 6.1
FCU 6.1
Crescentic glomerulonephritis 6.1
Influenza A virus infection 6.1
Apical periodontitis 6.1
trichophytosis 6.0
gout 6.0
Critically Ill 6.0
Intestinal ischemia 6.0
Streptococcus pneumoniae meningitis 6.0
Klebsiella pneumoniae infection 5.9
favus 5.9
Aspergillus fumigatus infection 5.9
Lumbar disc herniation 5.9
Submandibular gland 5.8
Parasitic infection 5.8
vascular ischemia 5.8
anthrax 5.7
Prostate tumor 5.7
Irritant contact dermatitis 5.7
PAPA 5.6
cough variant asthma 5.6
Middle cerebral artery occlusion 5.6
Candida sepsis 5.6
maple syrup urine disease 5.6
monocytic leukemia 5.6
endotoxic shock 5.5
diabetic cardiomyopathy 5.5
Burkitt-like lymphoma 5.5
Pulmonary infiltrates 5.5
Chronic inflammatory demyelinating polyradiculoneuropathy 5.5
Prosthetic valve endocarditis 5.5
AML progression 5.4
dental abscess 5.4
Oral infection 5.4
closed angle glaucoma 5.3
Diarrheal disease 5.3
DSS 5.3
Fungal keratitis 5.3
Schnitzler syndrome 5.2
Legionella 5.2
Asherman's syndrome 5.2
Shigella flexneri 5.1
Recessive dystrophic epidermolysis bullosa 5.1
mouse leukemia L1210 5.1
PFD 5.1
RP3 5.1
testicular dysfunction 5.1
Ureteral obstruction 5.1
Visna 5.0
pseudotuberculosis 5.0
DSS 5.0
Diabetes and Pregnancy 5.0
FAB M4 5.0
aggressive lymphoma 5.0
salivary gland cancer 5.0
Aeromonas hydrophila infection 5.0
VES 4.9
Dengue hemorrhagic fever 4.9
legionellosis 4.9
Diabetic peripheral neuropathy 4.9
PCD 4.9
VISA 4.9
Maedi 4.8
genital infection 4.8
bullous dermatoses 4.8
tularemia 4.8
Sendai virus infection 4.7
bacterial infection 4.7
pseudogout 4.7
salmonellosis 4.7
Gram-negative bacteremia 4.7
Plasmodium vivax infection 4.7
Shigella 4.7
Renal fibrosis 4.6
Small intestine 4.6
pulpitis 4.6
X-linked lymphoproliferative syndrome 4.6
geographic tongue 4.5
cardiac overload 4.5
AA amyloidosis 4.5
acute monocytic leukemia 4.5
immunopathology 4.5
infectious colitis 4.5
Allergic asthma 4.5
Invasive pulmonary aspergillosis 4.5
colitis 4.5
T-cell deficiency 4.5
Alcoholic liver disease 4.5
normocytic anemia 4.4
Pseudomonas infection 4.4
GM2 gangliosidosis 4.4
Hidradenitis suppurativa 4.4
Franklin 4.4
chronic cystitis 4.4
Cerebral venous thrombosis 4.3
renal ischemia 4.3
OPS 4.3
vibriosis 4.3
Yersinia 4.3
alcoholic fatty liver 4.3
pregnancy disorder 4.3
Werdnig-Hoffmann disease 4.3
low-grade lymphomas 4.2
LAD2 4.2
Classical swine fever 4.2
Choriocarcinoma 4.2
PIE 4.2
enterocolitis 4.2
Age-related macular degeneration 4.2
SOST 4.2
PME 4.2
Mixed infection 4.2
polyradiculoneuropathy 4.2
Autoimmune hepatitis 4.2
Blocking 4.2
peritonitis 4.2
CMD 4.1
more...
Symptom
Chronic pelvic pain syndrome 7.4
localized erythema 7.4
General symptoms 6.4
peri-menopausal 4.8
male subfertility 4.3
dry eye 3.5
hyperoxia 3.1
despair 2.7
dry skin 2.3
emaciation 2.3
chills 2.2
abnormal gait 2.2
collapse 2.1
memory loss 2.1
arthralgia 1.8
splenomegaly 1.6
hypothermia 1.5
starvation 1.5
respiratory distress 1.5
chorea 1.3
tense 1.2
functional recovery 1.2
exhaustion 1.2
acute stress 1.1
asthenia 0.9
cachexia 0.8
polyuria 0.7
flushing 0.7
diarrhea 0.7
myalgia 0.6
erythema 0.6
anorexia 0.6
cerebellar ataxia 0.5
acidity 0.4
nausea 0.4
acute pain 0.4
pelvic pain 0.3
apathy 0.3
overweight 0.2
distraction 0.1
fatigue 0.1
nausea and vomiting 0.1
vomiting -0.1
seizures -0.1
pain -0.1
headache -0.1
lethargy -0.2
hepatomegaly -0.2
cough -0.2
back pain -0.3
ataxia -0.6
dystonia -0.7
syncope -0.9
dyspnea -0.9
analgesia -0.9
constipation -1.0
abdominal pain -1.0
Ill -1.1
sleepiness -1.3
anesthesia -1.4
chest pain -1.8
angina -2.1
discomfort -2.1
discomfort -2.3
Drug
Mifobate 12.3
Talabostat 10.5
Bv2 9.8
Lexatumumab 9.7
CED 9.5
CA-074 8.5
Platonin 8.4
Rilonacept 8.3
Atractylodes rhizome 8.1
Ferric ammonium citrate 7.9
Roferon A 7.9
Hirudoid 7.5
Adenosine Monophosphate 7.4
Irofulven 7.4
Anakinra 7.3
Peanut oil 7.2
Interferon alfa-2a 6.9
Amlexanox 6.8
Tenidap 6.5
Butaprost 6.4
Tipifarnib 6.2
IL-1ra 6.1
AMC 6.0
Gold sodium thiomalate 6.0
Lipitor 5.9
3-Methyladenine 5.9
Batimastat 5.8
Batimastat 5.8
Immune globulin 5.7
Glybenclamide 5.7
Paliperidone 5.6
Lipitor 5.5
Lipitor 5.5
Auranofin 5.5
Red ginseng 5.4
Pirfenidone 5.4
Idebenone 5.4
Pepstatin 5.4
Clodronate 5.3
Zevalin 5.3
Rhubarb 5.3
Propidium 5.3
Aliskiren 5.3
ROS 5.2
Saha 5.2
Vinpocetine 5.1
Rebamipide 5.1
Tianeptine 5.0
Flavopiridol 4.6
Idarubicin 4.6
Rifaximin 4.6
Tocilizumab 4.6
Rutin 4.5
Epigallocatechin 4.5
IFN-beta 4.3
Compound 9 4.3
Lactase 4.2
Etoposide 4.2
Emodin 4.1
PPA 4.1
Silica gel 4.1
DEX 4.1
Kainic acid 4.0
Mycophenolic acid 3.9
G-CSF 3.9
Glycyrrhiza 3.8
Parkin 3.8
Parkin 3.8
Tannic acid 3.7
Olive oil 3.7
Rosiglitazone 3.6
Cilostazol 3.6
Ginseng 3.6
Propofol 3.6
Aminoguanidine 3.6
IFN-gamma 3.6
Rolipram 3.6
CCL 3.6
Liraglutide 3.5
Adenosine triphosphate 3.5
TTC 3.4
Fludarabine 3.4
Emodin 3.4
CPT-11 3.4
KGF 3.4
PFT 3.4
TAK 3.4
Heme 3.3
Imiquimod 3.3
Orphan 3.2
Donepezil 3.2
TES 3.2
Silica 3.1
Taxotere 3.0
VCR 3.0
R1881 3.0
Arsenic trioxide 3.0
Taxol 3.0
Nitric Oxide 3.0
Alliance 2.9
Phosphatidylserine 2.9
BH4 2.7
p75 2.7
Riboflavin 2.7
CIA 2.7
AGG 2.7
Zoledronic acid 2.7
Irinotecan 2.6
Simvastatin 2.6
APD 2.5
Amoxicillin 2.5
Sodium nitroprusside 2.4
-deoxyadenosine 2.3
ACT 2.2
Paraffin 2.2
Estrogens 2.2
Infliximab 2.2
Infliximab 2.2
Gefitinib 2.1
Aloe 2.1
RFP 2.1
Azithromycin 2.1
Serum albumin 2.0
CSF 2.0
CoCl2 2.0
CoCl2 2.0
Methylene blue 2.0
Pronase 2.0
ETS 1.9
Honey 1.9
NBT 1.9
Lovastatin 1.9
AZT 1.9
BLM 1.9
Alanine 1.9
Rituximab 1.8
Gleevec 1.8
IL-2 1.8
Sorafenib 1.7
AZT 1.7
balanced salt solution 1.7
VCR 1.7
Triclosan 1.7
Ranitidine 1.7
Cimetidine 1.7
TAC 1.6
Acacia 1.6
Cimetidine 1.6
Activin 1.6
PTC 1.5
Docetaxel 1.5
Glutathione 1.5
FAD 1.5
Histamine 1.4
Fluorescein 1.4
Monit 1.4
Ethanol 1.4
Bifidobacterium 1.4
ADR 1.3
Indomethacin 1.3
more...
Enzyme
caspase-1 12.3
caspase-5 11.7
caspase-11 11.5
caspase-5 11.5
caspase-11 11.4
proteinase A 10.6
caspase-4 10.6
caspase-4 10.4
thermomycolase 9.5
meprin B 9.4
Pla 9.0
caspase-6 9.0
adenain 8.7
caspase-6 8.7
caspase-2 8.6
caspase-2 8.6
caspase-10 8.5
caspase-10 8.5
D-cysteine desulfhydrase 8.3
NS protease 8.3
caspase-7 8.2
caspase-7 8.0
streptomycin adenylyltransferase 8.0
streptopain 7.7
caspase-8 7.5
granzyme M 7.4
cathepsin V 7.3
alpha-lytic protease 7.1
cathepsin B 6.9
aspartase 6.9
granzyme K 6.9
cholesterol 25-hydroxylase 6.8
mevalonate kinase 6.7
caspase-3 6.7
deoxyhypusine hydroxylase 6.3
serralysin 6.2
legumain 6.0
TSP-1 5.9
apyrase 5.7
caspase-9 5.7
granzyme B 5.6
RGP 5.5
proteinase-3 5.5
PARP 5.4
xyloglucan endotransglycosylase 5.4
phosphoserine phosphatase 5.2
DNase II 5.1
macrophage elastase 5.1
cathepsin X 5.1
ATP diphosphohydrolase 5.0
deoxyhypusine synthase 5.0
pseudouridine synthase 5.0
nucleoside diphosphokinase 5.0
3C protease 5.0
separase 4.9
Omi/HtrA2 4.9
proteinase A 4.8
meprin 4.8
HK2 4.8
triose-phosphate isomerase 4.8
IKK 4.7
NADPH oxidase 4.7
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.7
TdT 4.6
NADPH oxidase 4.6
AMPK 4.5
phosphatidylethanolamine N-methyltransferase 4.5
fatty acid desaturase 4.4
clostripain 4.4
cathepsin S 4.3
cathepsin G 4.3
C3b inactivator 4.3
SpeB 4.2
cathepsin L 4.2
conjugase 4.2
fumarylacetoacetate hydrolase 4.1
LIS 4.1
MPP 4.0
thermolysin 4.0
AMP-activated protein kinase 4.0
MsrA 4.0
NAT 3.9
lactate dehydrogenase 3.8
fructokinase 3.8
neutrophil elastase 3.8
cathepsin C 3.7
TACE 3.7
transaldolase 3.7
m-calpain 3.6
mitogen-activated protein kinase 3.6
cathepsin D 3.6
AMPK 3.6
carboxypeptidase Y 3.5
AST 3.5
chymase 3.5
lactic acid dehydrogenase 3.5
topoisomerase 3.5
AMP-activated kinase 3.4
adenosine kinase 3.4
chymosin 3.4
topoisomerase 3.4
interstitial collagenase 3.4
lactic acid dehydrogenase 3.4
HMG-CoA synthase 3.4
glucosylceramide synthase 3.4
MMP-3 3.4
histidine decarboxylase 3.4
RNase III 3.3
angiotensin-converting enzyme 2 3.3
BMT 3.3
CYP27A1 3.2
HtrA 3.2
MIP 3.2
ADPase 3.2
xanthine oxidase 3.2
3-hydroxy-3-methylglutaryl-CoA reductase 3.2
isopeptidase 3.2
proteasome 3.2
myrosinase 3.2
protein phosphatase 2A 3.1
alanine aminotransferase 3.1
xanthine dehydrogenase 3.0
factor C 3.0
PCE 3.0
elastase 3.0
peroxiredoxin 2.9
mu-calpain 2.9
DNA ligase 2.9
DNA ligase 2.9
E-2 2.8
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.8
superoxide dismutase 2.8
soluble epoxide hydrolase 2.8
CEP 2.8
lactic acid dehydrogenase 2.7
ClpP 2.7
aspartate aminotransferase 2.7
NQO1 2.7
MCS 2.7
fructose 1,6-bisphosphatase 2.7
ubiquitin-protein ligase 2.7
ricin 2.7
dihydropyrimidine dehydrogenase 2.6
diamine oxidase 2.6
papain 2.6
luciferase 2.6
NO synthase 2.6
BAT 2.6
12-lipoxygenase 2.6
tryptophan 2,3-dioxygenase 2.6
aconitase 2.5
S-adenosylmethionine decarboxylase 2.5
myosin light chain kinase 2.5
SPT 2.5
cathepsin K 2.5
enolase 2.4
arginase 2.4
GAS 2.4
pepsin 2.4
PRE 2.4
more...
Compound
Ginsenoside Rf 10.7
ASC 10.5
2-methyl-6-undecylpiperidine 10.3
Chelidonic acid 10.3
Theasinensin A 10.0
Nodakenin 9.7
5-Methoxytryptophan 9.7
Cucurbitacin D 9.1
CMK 8.9
3,4-pyridinedicarboxylic acid 8.8
2-hydroxy-1-propanesulfonic acid 8.8
1-heptadecene 8.4
Dracorhodin 8.3
Wedelolactone 8.3
Rhaponticin 8.2
Ruscogenin 8.1
Nigericin 7.9
Gedunin 7.8
Micheliolide 7.8
Micheliolide 7.8
Menthone 7.8
DCB 7.6
DCB 7.6
4-phenyl-2-butanone 7.5
LLY 7.5
Sodium hydrosulfide 7.5
Eudesmol 7.4
Propantheline 7.4
DCB 7.4
Diisononyl phthalate 7.4
Mauve 7.4
Androstenediol 7.4
N-acetyltryptophan 7.4
4-phenyl-2-butanone 7.4
Gentiopicroside 7.4
Acacetin 7.3
Aluminum hydroxide 7.3
Loganin 7.3
Dihydromyricetin 7.3
Merbarone 7.3
Purpurin 7.3
Physcion 7.3
Chrysophanol 7.2
Stearidonic acid 7.1
Geranylgeraniol 7.1
DCB 7.1
Chrysophanol 7.1
27-Hydroxycholesterol 7.1
Sinigrin 7.1
DCB 7.0
Aucubin 6.9
TPCK 6.9
AS-101 6.9
TKB 6.9
THP 6.9
THP 6.8
AICA-riboside 6.8
Isoorientin 6.7
cinnamyl acetate 6.6
Pristimerin 6.6
Pristimerin 6.6
Pristimerin 6.6
Pristimerin 6.6
IVE 6.6
Ziram 6.6
Fluocinolone acetonide 6.6
14,15-DHET 6.5
T 12 6.5
iodic acid 6.5
Pulegone 6.5
EGT 6.4
Gadolinium chloride 6.4
Pelargonidin 6.4
Harmine 6.4
L-chicoric acid 6.4
Triphosphate 6.4
Liquiritigenin 6.3
10-Hydroxycamptothecin 6.3
Alum 6.3
Garcinol 6.2
Benzamidine 6.1
Sinomenine 6.1
Dolichol 6.1
Bilobalide 6.1
Nerolidol 6.1
Vanillic acid 6.0
Nerolidol 6.0
Z-Gly-Pro 6.0
D-Galactosamine 6.0
Isoliquiritigenin 5.9
3-Methyladenine 5.9
Paeonol 5.9
Cinnamaldehyde 5.9
Shikonin 5.9
Brilliant Blue 5.9
Ifosfamide 5.9
Withaferin A 5.8
Etorphine 5.8
Rhein 5.8
Cepharanthine 5.8
Glibenclamide 5.8
Dioscin 5.8
Dioscin 5.8
HEI 5.7
25-Hydroxycholesterol 5.7
Dexmedetomidine 5.7
Latrunculin B 5.7
Natamycin 5.7
Genipin 5.6
Hyperoside 5.6
Diallyl disulfide 5.6
Diallyl disulfide 5.6
Oridonin 5.6
Fluvastatin 5.6
NIX 5.5
Celastrol 5.5
DHM 5.5
Allicin 5.5
DOD 5.5
celastrol 5.5
Ethyl pyruvate 5.5
Asiatic acid 5.4
Juglone 5.4
Thymoquinone 5.4
Cuprizone 5.4
Mangiferin 5.4
Dibucaine 5.4
Matrine 5.4
Matrine 5.4
Matrine 5.4
isonicotinamide 5.4
Cytochalasin D 5.4
Galangin 5.3
Sulforaphane 5.3
AFC 5.3
9H-xanthen-9-one 5.3
Taxifolin 5.3
Catalpol 5.3
Gambogic acid 5.3
Formononetin 5.3
BzATP 5.3
Rifamycin 5.2
Evodiamine 5.2
Polydatin 5.2
PIPES 5.2
PIPES 5.2
PIPES 5.2
Staurosporine 5.2
Dimethyl fumarate 5.2
Iodoacetamide 5.2
Biochanin A 5.2
Morin 5.1
Evodiamine 5.1
Phloretin 5.1
Staurosporine 5.1
Paeoniflorin 5.1
Cordycepin 5.1
Cordycepin 5.1
6-Gingerol 5.1
Surfactin 5.1
more...