Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NLRP3 1473
IL-18 1252
ICE 1052
cytokine 932
ASC 683
caspase-3 679
pyrin 560
Mol 445
Caspase-1 422
IL-1 421
lipopolysaccharide 410
Sep 369
NOD 353
IL-6 349
ATP 346
TNF 344
LPS 335
AIM2 275
tumor necrosis factor 258
caspase-8 248
THP 240
NLRC4 231
TLR4 226
Bcl-2 226
Fas 213
CPP32 165
IFN 156
adaptor protein 145
ROS 142
cysteine protease 141
gasdermin D 136
interferon 131
interleukin-18 126
p53 123
P2X7 113
NLRP1 112
PARP 110
apoptosis-associated speck-like protein containing a CARD 110
insulin 104
p38 103
AII 103
NALP3 102
cytochrome c 101
p65 100
cathepsin B 99
TLR2 95
CD4 94
IL-10 93
IL-8 93
poly(ADP-ribose) polymerase 93
MyD88 87
MAPK 84
CED 81
caspase-9 78
lactate dehydrogenase 78
IL-1 beta 77
Cytokine 77
inducible nitric oxide synthase 75
interacting protein 75
IL-17 71
bcl-2 70
TNF-alpha 69
IFN-gamma 68
JNK 66
p20 66
IL-33 65
Fas ligand 63
endoplasmic reticulum 61
p10 61
CD95 58
chemokine 57
interferon-gamma 56
superoxide dismutase 56
gasdermin 55
GSDMD 54
CMK 53
myeloperoxidase 52
mast cell 51
gut 51
collagen 51
IL-4 49
interleukin-6 48
proteasome 47
LDH 47
serine protease 46
Pseudomonas 45
P2X 45
calpain 43
thymic stromal lymphopoietin 43
TXNIP 40
CD8 40
MCP-1 40
GSH 39
lymphoid 39
NLRP3 protein 38
ubiquitin 38
HMGB1 38
IL1B 37
protease inhibitor 37
tumor necrosis factor alpha 37
annexin V 37
NLRP6 36
APO-1 36
FLICE 35
ERK 35
p62 34
catalase 34
CASP1 34
LC3 33
ERK1 33
c-Jun 33
bax 32
CD11b 32
thioredoxin 32
granzyme B 32
cyclooxygenase-2 31
IgE 31
IL18 31
high mobility group box 1 30
nitric oxide synthase 30
FADD 30
histone 30
adapter protein 30
Nrf2 29
p35 29
erythroid 29
mitogen-activated protein 29
SOD 29
AMPK 28
NALP1 28
inhibitor of apoptosis 27
NOD2 27
Chlamydomonas 26
caspase 2 25
CBF 24
Interleukin-18 24
RIP2 24
STAT1 24
interleukin 1 beta 24
CD14 23
interleukin 18 23
p21 23
FasL 23
phosphatase 23
p38 mitogen-activated protein kinase 23
CXCL1 22
mTOR 22
tyrosine kinase 22
TNF receptor 22
TLR9 22
extracellular signal-regulated kinase 22
ADP 22
ICAM-1 22
ATPase 22
RIPK1 22
polypeptide 22
IPAF 22
NAIP 22
Bid 22
HO-1 21
more...
Disease
cancer 383
NOD 353
tumor 272
sepsis 139
sepsis 137
diabetes 136
atherosclerosis 124
ischemia 122
Alzheimer's disease 120
infectious diseases 108
obesity 92
colitis 86
virus infection 85
bacterial infection 80
stroke 80
type 2 diabetes 72
cold 71
leukemia 70
arthritis 66
gout 65
Infection 65
tumorigenesis 63
rheumatoid arthritis 61
pneumonia 59
asthma 57
inflammatory bowel disease 55
peritonitis 54
HIV 54
Mycobacterium 53
tuberculosis 51
Legionella 51
hepatocellular carcinoma 50
multiple sclerosis 49
cerebral ischemia 49
Parkinson's disease 49
melanoma 48
carcinoma 47
depression 47
anthrax 43
influenza 43
breast cancer 42
lymphoma 41
tumor growth 40
GSH 39
cardiovascular disease 38
Yersinia 38
familial Mediterranean fever 36
cognitive impairment 36
myocardial infarction 34
neuroblastoma 34
amyotrophic lateral sclerosis 34
heart failure 34
Blocking 32
Shigella 32
B-cell lymphoma 32
atopic dermatitis 32
psoriasis 32
chronic obstructive pulmonary disease 30
systemic lupus erythematosus 30
colorectal cancer 29
AIDS 29
periodontitis 28
myocardial ischemia 27
carcinogenesis 27
Crohn's disease 27
hypertension 27
salmonellosis 26
immunodeficiency 26
Chlamydia 26
dermatitis 26
Hodgkin's disease 25
ulcerative colitis 25
hyperglycemia 25
acute myeloid leukemia 24
encephalomyelitis 24
liver disease 24
cowpox 24
renal disease 24
metabolic syndrome 23
lung cancer 23
tumor progression 23
plaque 23
diabetic retinopathy 22
thrombocytopenia 22
diabetic nephropathy 22
autoimmune disease 21
Shigella flexneri 21
metastases 20
chronic myeloid leukemia 20
hepatitis 20
colon cancer 20
proteinuria 19
neutropenia 19
allergic rhinitis 19
liver fibrosis 18
macular degeneration 18
suicide 18
immunopathology 18
Muckle-Wells syndrome 18
osteoarthritis 18
skin disease 18
lupus 17
fatty liver 17
meningitis 17
malnutrition 16
lupus 16
prostate cancer 16
tularemia 16
pseudotuberculosis 16
acute myocardial infarction 16
MCF 16
preeclampsia 15
dementia 15
SDS 15
diabetic cardiomyopathy 15
gastric cancer 15
retinoblastoma 15
malaria 15
type 1 diabetes 15
squamous cell carcinoma 15
Huntington's disease 15
non-small cell lung cancer 15
dengue 14
alcoholic fatty liver 14
cholera 14
glioma 14
lung disease 13
Leukemia 13
periodontal disease 13
syphilis 13
endotoxic shock 13
hyperuricemia 13
acne 13
cystic fibrosis 12
brain edema 12
Klebsiella 12
graft-versus-host disease 12
sarcoma 12
pancreatitis 12
DSS 11
herpes simplex 11
mastitis 11
adenocarcinoma 11
DSS 11
skin cancer 11
cirrhosis 11
fungal infection 11
acute renal failure 11
myelosuppression 11
FAS 11
hyperlipidemia 11
idiopathic pulmonary fibrosis 11
STD 11
non-Hodgkin's lymphoma 11
epilepsy 10
SARS 10
cytomegalovirus 10
acute pancreatitis 10
myocarditis 10
leishmaniasis 10
more...
Symptom
pain 47
collapse 25
diarrhea 18
seizures 15
starvation 14
fatigue 11
respiratory distress 11
hypothermia 10
headache 10
hyperoxia 9
anesthesia 8
splenomegaly 6
nausea 6
vomiting 6
exhaustion 6
dry eye 6
overweight 6
functional recovery 6
arthralgia 5
acidity 4
cough 4
erythema 4
anorexia 4
chills 4
abdominal pain 3
dyspnea 3
memory loss 3
analgesia 3
ataxia 2
nausea and vomiting 2
distraction 2
back pain 2
acute stress 2
cachexia 2
myalgia 2
despair 2
flushing 2
discomfort 1
asthenia 1
chest pain 1
chorea 1
hepatomegaly 1
apathy 1
constipation 1
male subfertility 1
abnormal gait 1
lethargy 1
discomfort 1
dry skin 1
sleepiness 1
peri-menopausal 1
syncope 1
dystonia 1
emaciation 1
angina 1
tense 1
pelvic pain 1
polyuria 1
cerebellar ataxia 1
Ill 1
localized erythema 1
General symptoms 1
Chronic pelvic pain syndrome 1
acute pain 1
Drug
ROS 142
CED 81
IFN-gamma 68
Dermatol 46
CSF 25
IL-2 20
Cardiovasc 20
IL-1ra 19
Monit 18
lysine 15
AMC 15
G-CSF 15
IFN-beta 12
Anakinra 8
CA-074 8
MAP 7
Heme 6
Ethanol 5
Parkin 5
Parkin 5
Taxol 5
p75 5
Propofol 5
Gel 5
ampicillin 5
CPT-11 4
Asthma 4
ascorbate 4
TTC 4
Asn 4
Ginseng 4
Nitric Oxide 4
Glycyrrhiza 4
Etoposide 4
Silica 4
CTX 4
vitamin E 4
Alliance 4
Histamine 3
Leaf 3
CCL 3
Rutin 3
Glutathione 3
Indomethacin 3
FAD 3
lactose 3
ZnO 3
DEX 3
Spectrum 3
DNase I 3
Bifidobacterium 3
Auranofin 3
CaCl2 2
Arsenic trioxide 2
Estrogens 2
CaCl2 2
CaCl2 2
Biopolymers 2
Aliskiren 2
CAM 2
Simvastatin 2
Rituximab 2
PPA 2
Propidium 2
Epigallocatechin 2
CTX 2
3-Methyladenine 2
Kainic acid 2
AZT 2
Rosiglitazone 2
CTX 2
ACT 2
ABC 2
caffeine 2
Alanine 2
Tocilizumab 2
Emodin 2
Bv2 2
-deoxyadenosine 2
NADH 2
TAK 2
Talabostat 2
BH4 2
Clodronate 2
AZT 2
Fluorescein 2
Pirfenidone 2
Paraffin 2
Adenosine triphosphate 2
ETS 2
balanced salt solution 1
Vinpocetine 1
Dial 1
Mycophenolic acid 1
Irofulven 1
Angiotensin II 1
ADR 1
Cilostazol 1
Infliximab 1
Rilonacept 1
MRC 1
Docetaxel 1
Triclosan 1
Tenidap 1
Orphan 1
AGG 1
Olive oil 1
NBT 1
Silica gel 1
Pronase 1
PTC 1
KGF 1
Acacia 1
THF 1
Paliperidone 1
Azithromycin 1
Lipitor 1
Rolipram 1
Amlexanox 1
Lovastatin 1
Fragment 1
Tannic acid 1
Roferon A 1
Imatinib 1
Methylene blue 1
Hirudoid 1
Mifobate 1
Imiquimod 1
TAT 1
HCG 1
Spectrum 1
BLM 1
niacin 1
Idebenone 1
Tipifarnib 1
APD 1
Vitamin E 1
Compound 9 1
VCR 1
VCR 1
Cimetidine 1
Forskolin 1
Riboflavin 1
Adriamycin 1
citric acid 1
Peanut oil 1
Amoxicillin 1
Gefitinib 1
TAC 1
Emodin 1
Lipitor 1
Phosphatidylserine 1
Pepstatin 1
MDS 1
Donepezil 1
CIA 1
Lactase 1
RFP 1
Irinotecan 1
Saha 1
more...
Enzyme
caspase-1 6285
caspase-3 741
caspase-8 245
mitogen-activated protein kinase 232
caspase-11 194
caspase-11 193
PARP 116
caspase-4 110
caspase-4 108
cathepsin B 99
Pla 90
lactate dehydrogenase 82
proteinase A 81
superoxide dismutase 80
caspase-9 76
caspase-2 64
protein kinase 63
caspase-2 60
peroxidase 58
caspase-7 54
NADPH oxidase 53
NADPH oxidase 52
proteasome 51
caspase-5 51
caspase-6 49
caspase-5 48
caspase-7 46
ERK 46
luciferase 46
alanine aminotransferase 44
catalase 41
AMP-activated protein kinase 41
caspase-6 39
granzyme B 32
focal adhesion kinase 29
AMPK 29
aspartate aminotransferase 28
AMPK 28
IKK 25
trypsin 24
ATPase 23
topoisomerase 21
reverse transcriptase 21
topoisomerase 20
ACS 20
protein kinase C 19
NO synthase 19
apyrase 16
xanthine oxidase 15
elastase 14
AST 14
caspase-10 13
MEK 13
caspase-10 13
glutathione S-transferase 12
tyrosine hydroxylase 11
ACE 11
neutrophil elastase 11
thrombin 11
calcineurin 11
endonuclease 11
glutathione peroxidase 10
chymotrypsin 10
cathepsin D 10
RNA polymerase 10
TSP-1 10
pepsin 9
TdT 9
alkaline phosphatase 9
MIP 9
creatine kinase 9
NQO1 8
papain 8
RNase 8
mevalonate kinase 8
RNase 8
collagenase 8
cathepsin G 7
complex I 7
cathepsin L 7
adenylate cyclase 7
MMP-3 7
cdc2 7
GSK 7
lipase 7
CD10 6
phospholipase C 6
MPP 6
MAP 6
phosphatidylinositol 3-kinase 6
phospholipase A2 6
thermolysin 6
transcriptase 6
urease 5
BMT 5
renin 5
phosphoinositide 3-kinase 5
protein phosphatase 2A 5
urease 5
aspartase 5
legumain 5
glyceraldehyde-3-phosphate dehydrogenase 5
phosphodiesterase 5
succinate dehydrogenase 4
DNA ligase 4
DNA ligase 4
guanylate cyclase 4
invertase 4
enolase 4
DNase 4
peroxiredoxin 4
APC 4
NOS 4
ricin 4
arginase 4
MMP 4
alpha-lytic protease 3
heme oxygenase 3
DNase II 3
glutathione reductase 3
fatty acid desaturase 3
lipoxygenase 3
carboxypeptidase Y 3
chymase 3
alpha-glucosidase 3
myosin light chain kinase 3
beta-galactosidase 3
chitinase 3
thromboplastin 3
subtilisin 3
DNA polymerase 3
proteinase K 3
HK2 3
soluble epoxide hydrolase 3
proteinase-3 3
diamine oxidase 3
meprin 3
histidine decarboxylase 3
3C protease 3
NAT 2
3-hydroxy-3-methylglutaryl-CoA reductase 2
adenosine deaminase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glucose-6-phosphate dehydrogenase 2
PCE 2
aldolase 2
glyceraldehyde-3-phosphate dehydrogenase 2
P-glycoprotein 2
adenosine deaminase 2
RNase III 2
paraoxonase 2
ornithine decarboxylase 2
HSD 2
histone acetyltransferase 2
aconitase 2
neuraminidase 2
lysozyme 2
glyceraldehyde-3-phosphate dehydrogenase 2
thymidylate synthase 2
PRE 2
more...
Compound
ASC 683
DNA 602
oxygen 532
Dec 394
ATP 346
TNF 344
THP 240
THP 240
leucine 230
cysteine 228
Asp 190
glucose 173
calcium 149
water 135
Clin 129
potassium 127
alanine 120
sodium 109
nitric oxide 106
serine 95
tyrosine 82
acetate 71
sulfate 70
aldehyde 54
aldehyde 54
CMK 53
dUTP 49
N-acetylcysteine 47
hydrogen 44
GSH 40
GSH 40
phosphate 37
nitrogen 37
glutamate 33
ethanol 32
zinc 31
iodine 29
MTT 28
creatinine 28
lysine 28
arginine 27
salt 27
MDA 26
Cardiol 24
aspartic acid 24
ADP-ribose 24
His 23
aspartic acid 22
iron 22
ADP 22
aspartic acid 22
ADP 22
aspartic acid 22
cAMP 22
ADP 22
Phe 21
methionine 21
urea 21
aluminum 20
AMP 20
ACS 20
ACS 20
DBP 19
DCB 19
DCB 19
DCB 19
DCB 19
H2O2 19
DCB 19
proline 19
palmitic acid 18
threonine 18
NH2 18
CO2 18
SDS 16
silver 16
NADPH 15
copper 15
Neuronal 15
NADPH 15
Cereb 14
MPTP 14
DMSO 14
galactose 14
Melatonin 14
VP-16 13
GMP 13
Glibenclamide 13
palmitic acid 13
cGMP 13
Panam 13
PMA 13
PMA 12
H2S 12
retinoic acid 11
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 11
DSS 11
nicotinamide 11
glutamic acid 11
EDTA 10
pyrrolidine 10
cadmium 10
pyrrolidine 10
ADR 10
Adriamycin 10
APAP 10
EDTA 10
glycerol 10
PGE 10
Curcumin 9
titanium 9
Dexmedetomidine 9
DDP 9
Metformin 9
Gly 9
vitamin D 9
COS 9
Uric acid 9
TPCK 9
Metformin 9
Insulin 9
Leucine 8
Brilliant Blue 8
boron 8
asparagine 8
ammonium 8
manganese 8
PGE2 8
Retinal 8
DEAE 8
Resveratrol 8
tryptophan 8
Nigericin 8
NAD 8
NAD 8
Alum 8
NKT 8
Paclitaxel 8
selenium 8
Ang II 8
STZ 8
Staurosporine 8
bromide 8
Staurosporine 8
nitrate 8
homocysteine 7
tryptophan 7
nickel 7
silicon 7
Hematoxylin 7
hydroxide 7
TBI 7
Mg2+ 7
CAT 7
tryptophan 7
cyanide 7
MAP 7
oxalate 7
CAT 7
ethyl acetate 7
more...