Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.36 (
caspase-1
)
6,285
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Members of the
ICE
/Ced-3 gene family are likely effector components of the cell death machinery. Here, we characterize a novel member of this family designated
ICE-LAP6
. By phylogenetic analysis,
ICE-LAP6
is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1. Interestingly,
ICE-LAP6
contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members. Overexpression of
ICE-LAP6
induces apoptosis in MCF7 breast carcinoma cells. More importantly,
ICE-LAP6
is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis. Once activated,
ICE-LAP6
is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.
...
PMID:ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. 866 94
