Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.36 (
caspase-1
)
6,285
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
estrogen-responsive B box protein
(
EBBP
) and Pyrin belong to a family of structurally related proteins. While mutations in the pyrin gene cause an autoinflammatory disease, the biological function of
EBBP
is unknown. In this study, we identified the proinflammatory cytokine interleukin-1beta (IL-1beta) as an
EBBP
-binding partner. Furthermore,
caspase-1
and NACHT, LRR and Pyrin domain containing protein (NALP) 1, two components of the recently identified inflammasome, a platform for the activation of
caspase-1
, also interact with
EBBP
. These proteins bind to the RFP domain of
EBBP
, suggesting that this domain of so far unknown function is an important protein-binding domain.
EBBP
was secreted in a
caspase-1
-dependent manner from cultured cells, and its secretion was enhanced by IL-1beta. Vice versa, endogenous and overerexpressed
EBBP
increased IL-1beta secretion. These results provide evidence for a role of
EBBP
in innate immunity by enhancing the alternative secretion pathway of IL-1beta.
...
PMID:The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. 1657 8
