Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.36 (
caspase-1
)
6,285
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Salmonella
is important as both a cause of clinical disease in swine and as a source of food-borne transmission of disease to humans.
Lactobacillus
and
Bacillus
are often used as antibiotic substitutes to prevent
Salmonella
infection. In this study, we evaluated the effects of a select mixture of
Lactobacillus johnsonii
L531,
Bacillus licheniformis
BL1721 and
Bacillus subtilis
BS1715 (LBB-mix) in prevention of
Salmonella
enterica
serovar Infantis infection in a pig model. LBB-mix was orally administered to newly weaned piglets for seven days before
S
. Infantis challenge. LBB-mix pretreatment ameliorated
S
. Infantis-induced fever, leukocytosis, growth performance loss, and ileal inflammation. Pre-administration of LBB-mix reduced the number of
Salmonella
in the feces but increased the number of goblet cells in the ileum.
S
. Infantis infection resulted in an increase in cell death in the ileum, this increase was attenuated by LBB-mix consumption.
Claudin 1
and cleaved
caspase-1
expression was decreased in the ileum of pigs challenged with
S
. Infantis, but not in pigs pretreated with LBB-mix. In conclusion, our data indicate that a select LBB-mix has positive effects on controlling
S
. Infantis infection via alleviating inflammation and maintaining the intestinal mucosal barrier integrity in pigs.
...
PMID:Oral Administration of a Select Mixture of
Lactobacillus
and
Bacillus
Alleviates Inflammation and Maintains Mucosal Barrier Integrity in the Ileum of Pigs Challenged with
Salmonella
Infantis. 3109 80
