Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.36 (
caspase-1
)
6,285
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interferon regulatory factor 1
(
IRF-1
) is a transcriptional activator which exerts different biological activities.
IRF-1
activates interferon induced genes as well as genes which are not directly linked to the interferon system, such as the
ICE
protease gene.
IRF-1
activity is post-transcriptionally regulated in addition to transcriptional regulation by interferons, cytokines, hormones and many other factors. This includes heterodimerisation with activators and repressors of transcription. These protein interactions modulate the transactivating capacity of
IRF-1
. By using a two-hybrid system, we demonstrate that
IRF-1
forms homodimers in vivo. The homodimerization domain was determined to be located in the N-terminal part of
IRF-1
which belongs to the DNA-binding domain. Since this sequence is highly conserved between members of the IRF-family, our observation raises the question of homodimerization of other IRFs through this domain.
...
PMID:In vivo formation of IRF-1 homodimers. 986 88
