Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have investigated whether niacin-related compounds act as inducers of apoptosis in HL-60 cells. In this study, we found that picolinic acid, dipicolinic acid, and isonicotinamide strongly induce apoptosis. After treatments with these compounds, apoptosis started within 4 h and was induced in about 50% of the cells within 8 h. These compounds induced apoptosis at 5-10 mM, but did not at 1 mM. An ICE-like protease inhibitor (Z-Asp-CH2-DCB) completely blocked the apoptosis, but a caspase-1 inhibitor (Ac-YVAD-CHO) and a caspase-3 inhibitor (Ac-DEVD-CHO) did not block the apoptosis, suggesting that other caspases have the critical roles in the execution process of apoptosis induced by niacin-related compounds.
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PMID:Apoptosis induced by niacin-related compounds in HL-60 cells. 997 61

It was found that picolinic acid, dipicolinic acid, and isonicotinamide strongly induce apoptosis in human acute myelomonocytic leukemia cells, HL-60. Cinchomeronic acid, quinolinic acid, N1-methylnicotinamide, 6-aminonicotinamide, and picolinamide were weak inducers of the apoptosis. After treatments with picolinic acid, dipicolinic acid, and isonicotinamide, apoptosis started within 4 hr and it was induced in about 50% of the cells within 8 hr. These compounds also induced apoptosis in human chronic myelogenous leukemia cells, K562 and human cervical carcinoma cells, HeLa. However, apoptosis was not induced by these three compounds in quiescent normal human lymphocytes. A wide spectrum caspase inhibitor perfectly prevented DNA fragmentation induced by these compounds. But, caspase-1 inhibitor and caspase-3 inhibitor did not block DNA fragmentation.
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PMID:[Vitamins and apoptosis--induction of apoptosis in human cancer cells by nicotinic acid-related compounds]. 1054 Aug 80