Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.36 (
caspase-1
)
6,285
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glycerol, a compatible solute, has previously been found to act as an osmoprotectant in some marine
Chlamydomonas
species and several species of
Dunaliella
from hypersaline ponds. Recently,
Chlamydomonas reinhardtii
and
Dunaliella salina
were shown to make glycerol with an unusual bidomain enzyme, which appears to be unique to algae, that contains a
phosphoserine phosphatase
and glycerol-3-phosphate dehydrogenase. Here we report that two psychrophilic species of
Chlamydomonas
(
C
. spp. UWO241 and
ICE
-MDV) from Lake Bonney, Antarctica also produce high levels of glycerol to survive in the lake's saline waters. Glycerol concentration increased linearly with salinity and at 1.3 M NaCl, exceeded 400 mM in
C
. sp. UWO241, the more salt-tolerant strain. We also show that both species expressed several isoforms of the bidomain enzyme. An analysis of one of the isoforms of
C
. sp. UWO241 showed that it was strongly upregulated by NaCl and is thus the likely source of glycerol. These results reveal another adaptation of the Lake Bonney
Chlamydomonas
species that allow them to survive in an extreme polar environment.
...
PMID:Glycerol Is an Osmoprotectant in Two Antarctic
Chlamydomonas
Species From an Ice-Covered Saline Lake and Is Synthesized by an Unusual Bidomain Enzyme. 3297 29
