Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.36 (caspase-1)
 6,285 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 12-year-old boy with primary intracranial choriocarcinoma of the pineal region suffered from repeated intratumoral hemorrhage over a short period. Neuroradiological images demonstrated a pineal-region tumor with intratumoral hemorrhage and obstructive hydrocephalus. HCG-beta subunit concentration of his serum and cerebrospinal fluid was abnormally high. After the 24.2Gy irradiation, the tumor was removed almost totally. After the operation, we treated him with additional radiation and chemotherapy using ifosfamide, cisplatin, and etoposide (namely ICE therapy). No recurrence or metastasis has been noted, and he was in good condition during the 22 months since the operation. At present he receives maintenance ICE therapy every 3 months. Choriocarcinoma involves a high possibility of intratumoral fatal hemorrhage, so a radical operation is recommended as soon as possible.
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PMID:[A successfully operated case of choriocarcinoma with recurrent intratumoral hemorrhage]. 1064 96

The natural history of external hydrocephalus (EH) in adults is often marked by conversion into internal hydrocephalus. We describe a complication of this conversion, the ICE (intracerebral CSF entrapment) phenomenon, and demonstrate that both EH and ICE represent a challenge to current theories on the pathophysiology of communicating hydrocephalus (CHC). We propose a new model for CHC where the pattern of CSF distribution is largely determined by the intrinsic compliance of each of the intracranial structures. In this model, failure of distal CSF absorption resulting in an excessive intracranial CSF volume is the common denominator and CSF diversion the common solution to all forms of CHC.
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PMID:Internal hydrocephalus, external hydrocephalus, and the syndrome of intracerebral cerebrospinal fluid entrapment: a challenge to current theories on the pathophysiology of communicating hydrocephalus. 1971 62