Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.32 (bromelain)
 1,025 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lymphoproliferative disease virus of turkeys (LPDV), a C-type retrovirus, was shown to contain 3 major [32 kilodaltons (kd, p 32), 26 kd, 22/21 kd] and 2 minor (41 kd and 12 kd) polypeptides. Preliminary evidence suggests a glycoprotein of 76 kd (GP 76) and a major doublet polypeptide of 13.5/13 kd to be also of viral origin. Of these GP 76 was susceptible to bromelain action implying its surface location in the virion, while p 32, p 26 and p 13.5/13 were the main constituents of viral cores. p 13.5/13 bound an RNA probe, suggesting it to be the main constituent of viral ribonucleoprotein. p 22/21 was not cleaved by bromelain, and was absent in viral cores suggesting its intramembrane location between virion envelope and core. The polypeptide profile of LPDV is distinct from those of avian sarcoma-leukosis viruses and avian reticuloendotheliosis viruses.
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PMID:Characterisation of lymphoproliferative disease virus of turkeys. Structural polypeptides of the C-type particles. 303 51

Lymphoproliferative disease virus, a recently isolated C-type retro-virus, cannot yet be cultured in cells in vitro and rarely induces a high titre virus-specific antiserum. However, after digestion of purified virus with bromelain and rebanding the treated virus in sucrose gradients bald virions devoid of the viral spike glycoprotein and up to 20 host proteins were found to induce a high level virus-specific antibody response in rabbits and chickens.
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PMID:Production of virus-specific antisera to lymphoproliferative disease virus of turkeys. 1876 56