Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.9 (enterokinase)
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Human Gene/Protein
enterokinase 15.5
enteropeptidase 15.5
Epitheliasin 14.5
epitheliasin 14.5
YSA1H 14.5
Serase-1B 14.5
mesotrypsinogen 14.1
spinesin 13.5
hemochromatosis type 2 13.5
HLAL 13.5
DESC1 13.2
trypsinogen 4 12.9
anionic trypsinogen 12.7
PHAP I 12.5
25KD 12.4
TMPRSS9 12.4
YSA1 12.4
trypsinogen 12.3
trypsin 1 12.1
Acid carboxypeptidase 12.1
mesotrypsin 11.9
frizzled 1 11.8
serine protease 1 11.5
PBII 11.4
GPR116 11.4
airway trypsin-like protease 11.4
corin 11.3
cationic trypsinogen 11.3
Pyrroline-5-carboxylate reductase 10.9
Complement receptor type 1 10.9
aldehyde oxidase 1 10.8
PRSS3 10.8
sperm protein 10.8
ALT2 10.7
insulinoma-associated protein 2 10.7
PTPRR 10.7
PRSS2 10.6
GRM6 10.6
sentrin-specific protease 10.6
MAT2 10.6
C4.4A 10.5
Trx 10.5
beta-tubulin protein 10.4
GPR126 10.3
HFE2 10.3
hepsin 10.3
BD6 10.3
Hexokinase-2 10.2
agrin 10.2
HD-6 10.2
neurotrypsin 10.1
collectrin 10.1
Nucleoporin 10.1
Interleukin-24 10.0
Corin 9.9
MT-SP1 9.9
TMPRSS4 9.9
O-sialoglycoprotein endopeptidase 9.8
TMPRSS3 9.7
PRSS1 9.7
single chain Fv fragment 9.7
LPA5 9.6
collagen-like protein 9.6
maltase-glucoamylase 9.4
OG2 9.4
beta-tryptase 9.4
DB5 9.3
ferroportin1 9.3
FHL-1 9.2
PAP2 9.2
fibrocystin 9.2
pancreatic secretory trypsin inhibitor 9.1
CD30 ligand 9.0
hemoglobin beta 9.0
trypsin-like serine protease 9.0
KIAA0319 9.0
ADAM8 9.0
Smad anchor for receptor activation 8.9
BDH 8.9
type II integral membrane protein 8.9
macrophage scavenger receptor 8.8
HSPG2 8.8
thioredoxin 8.8
TRX 8.7
MUC16 8.7
pT7 8.6
HEP 8.6
TMPRSS6 8.6
ST14 8.6
K23 8.6
matriptase 8.5
CD30L 8.5
neurosin 8.5
sucrase-isomaltase 8.4
pepsinogen A 8.3
Maltase 8.3
PAP1 8.3
elastase 1 8.2
TB10 8.2
lactase 8.2
MUC3 8.2
pepsinogen C 8.2
X mRNA 8.1
P23 8.1
HAP2 8.1
Calnexin 8.0
EPP 8.0
trypsin inhibitor 8.0
histidase 7.9
lactase-phlorizin hydrolase 7.9
matrix metalloproteinase 3 7.9
IMAC 7.9
brush border 7.7
pancreatic stone protein 7.7
mast cell tryptase 7.7
TDH 7.7
trehalase 7.7
NADP-malic enzyme 7.7
serine protease 7.7
colipase 7.7
hBD-3 7.7
HBD-3 7.7
AOX1 7.7
MUC1 7.7
D-lactate dehydrogenase 7.6
beta-defensin 7.6
IMPDH 7.6
Thioredoxin 7.6
chymotrypsin-like 7.6
Trypsin 7.6
low density lipoprotein receptor 7.6
serum amyloid A protein 7.5
PI-PLC 7.5
MUC4 7.5
MBL 7.5
leucine aminopeptidase 7.5
P2' 7.4
PTI 7.4
DMB 7.4
methionine aminopeptidase 7.4
type II membrane protein 7.4
chymase 7.4
Aminopeptidase 7.4
Tamm-Horsfall glycoprotein 7.3
hBD-2 7.3
BMP6 7.3
hemojuvelin 7.2
ECI 7.2
chimeric protein 7.2
intestinal mucin 7.2
HAL 7.2
chymotrypsin 7.2
Chymotrypsin 7.1
inter-alpha-trypsin inhibitor 7.1
aminopeptidase 7.1
granulysin 7.0
hK2 7.0
DIS 7.0
E.coli 7.0
IDA 7.0
intrinsic factor 7.0
Cam 7.0
TL1A 7.0
uromodulin 6.9
Antithrombin 6.9
prolyl oligopeptidase 6.9
GB1 6.9
CA15 6.9
beta II 6.9
IA-2 6.9
gastric inhibitory polypeptide 6.9
G15 6.9
guanylate kinase 6.9
RPC 6.9
Kv1.3 6.9
CCK-B 6.9
PBI 6.9
secretory leukocyte protease inhibitor 6.8
nidogen 6.8
MAT1 6.8
C40 6.8
factor Xa 6.8
endoprotease 6.8
TMPRSS2 6.7
Interleukin-15 6.7
MUC5B 6.7
Metalloproteinase 6.7
annexin A2 6.6
glucose-dependent insulinotropic polypeptide 6.6
Plasmin 6.6
p20 6.6
cysteine proteinase inhibitor 6.6
thrombin receptor 6.6
PRI 6.5
Hepcidin 6.5
NAT1 6.5
Alanine aminotransferase 6.5
FK506-binding protein 6.4
GP5 6.4
IGS 6.4
heavy chain 6.4
granzyme A 6.4
matrilysin 6.4
OXPHOS 6.3
PF4 6.3
perlecan 6.3
GST 6.3
cathepsin B 6.3
CDR2 6.3
gastric mucin 6.3
HAT 6.3
MT-1 6.3
GLP-1 6.2
FGF receptor 6.2
calnexin 6.2
Limulus polyphemus 6.2
wts 6.2
Cathepsin B 6.1
mucin 1 6.1
PAR-2 6.1
p60 6.1
CCK-A 6.1
phenylalanine hydroxylase 6.1
forkhead box P3 6.1
HIS 6.1
lipid transfer protein 6.1
PAR1 6.1
Carbonic anhydrase 6.1
GroES 6.1
p66 6.1
frizzled 6.1
CF2 6.1
secretin 6.0
Alkaline phosphatase 6.0
IGFBP-1 6.0
FAT 6.0
kappa-casein 6.0
Dance 6.0
BPI 6.0
FGF-2 6.0
HA2 6.0
alpha 1-antitrypsin 6.0
MCS 6.0
APH 5.9
amylase 5.9
tissue kallikrein 5.9
SRP 5.9
CH1 5.9
MAL 5.9
19A 5.9
12-lipoxygenase 5.9
carboxypeptidase B 5.9
HPI 5.9
B lymphocyte stimulator 5.9
TAP 5.8
DAG 5.8
MMP-7 5.8
cholecystokinin 5.8
signal peptidase 5.8
Ferritin 5.8
NAT2 5.8
fused 5.8
protein-tyrosine phosphatase 5.7
granulocyte colony stimulating factor 5.7
pepsinogen 5.7
HDAC3 5.7
oncostatin M 5.7
Elastin 5.7
leukocyte interferon 5.7
cathepsin G 5.7
growth hormone receptor 5.7
dipeptidyl peptidase IV 5.7
initiation factor 2 5.7
PFP 5.7
GLP-1 receptor 5.6
ANF 5.6
GAP 5.6
Phospholipase A2 5.6
E. coli) 5.6
Tyrosinase 5.6
lipoamide dehydrogenase 5.6
asialoglycoprotein receptor 5.6
C-terminal peptide 5.6
ANP 5.6
DTNB 5.6
35 kDa 5.6
defensin 5.6
alpha2-macroglobulin 5.5
TMT 5.5
N-acetyltransferase 5.5
short isoform 5.5
HDAC2 5.5
annexin II 5.5
lipase 5.5
DnaJ 5.5
G-protein coupled receptor 5.5
N-glycanase 5.5
LL-37 5.5
angiogenin 5.5
calcium binding protein 5.4
TRAIL 5.4
MBP 5.4
non-active 5.4
C-type natriuretic peptide 5.4
carbonic anhydrase II 5.4
p70 5.4
signal recognition particle 5.3
TSK 5.3
SUMO 5.3
binding peptide 5.3
ALDH 5.3
proopiomelanocortin 5.3
tissue factor pathway inhibitor 5.3
F1-ATPase 5.3
tetraspanin 5.3
IL-11 5.3
C4b-binding protein 5.3
calreticulin 5.3
repressor protein 5.2
granzyme B 5.2
more...
Disease
Intestinal enterokinase deficiency 15.5
Edematous pancreatitis 10.7
HFE2 9.4
glucose-galactose malabsorption 9.1
Acute necrotizing pancreatitis 9.0
HEP 8.6
chronic enteritis 8.0
alcoholic pancreatitis 7.6
pancreatic insufficiency 7.5
Tag 7.4
acrodermatitis enteropathica 7.1
Crabs 7.0
duodenitis 6.9
RPC 6.9
acute pancreatitis 6.7
western equine encephalomyelitis 6.5
trichuriasis 6.5
juvenile myelomonocytic leukemia 6.4
pancreatitis 6.4
steatorrhea 6.3
failure to thrive 6.1
lactose intolerance 6.0
MCS 6.0
MCS 6.0
monocytic leukemia 6.0
Lymph nodes 5.8
erythropoietic protoporphyria 5.8
HPC 5.6
chronic pancreatitis 5.5
protein deficiency 5.5
carcinoma of the pancreas 5.4
Pancreas 5.3
CCL 5.2
chronic myelomonocytic leukemia 5.1
Pancreas 5.1
malabsorption 5.0
SDS 5.0
Wells 4.9
EDC 4.8
Luminal 4.7
iron deficiency anemia 4.6
erythroleukemia 4.5
Schistosoma japonicum 4.4
Osteosarcoma 4.4
Osteosarcoma 4.4
enteropathy 4.4
ADH 4.4
biliary obstruction 4.3
HPA 4.1
EIA 4.1
listeriosis 4.0
PGA 3.9
seminal vesicles 3.8
Schistosoma mansoni 3.7
insulinoma 3.7
fibrosarcoma 3.7
Cryptococcus neoformans 3.5
celiac disease 3.4
Disorder 3.3
ICP 3.2
SCH 3.2
dyskinesia 3.2
adult respiratory distress syndrome 3.1
liver cancer 3.0
Adhesion 3.0
CTX 3.0
cystic fibrosis 2.9
bronchitis 2.9
bronchitis 2.8
Legionella 2.8
malnutrition 2.7
diphtheria 2.7
liver cancer 2.6
epididymis 2.5
peptic ulcer 2.5
Mycobacterium 2.4
schistosomiasis 2.4
gastric cancer 2.4
urethra 2.3
APC 2.2
hypercalcemia 2.2
influenza 2.0
tetanus 1.9
measles 1.9
ATM 1.9
encephalomyelitis 1.9
fatty liver 1.8
MCF 1.7
Down syndrome 1.7
bipolar disorder 1.7
pruritus 1.7
Colon 1.6
Colon 1.6
Colon 1.6
bacterial infection 1.6
tuberculosis 1.6
Haemophilus 1.6
peritonitis 1.6
glioma 1.6
coma 1.6
osteosarcoma 1.5
Best 1.4
mole 1.4
alcoholism 1.4
chronic myeloid leukemia 1.3
carcinoma 1.3
type 2 diabetes 1.3
pertussis 1.3
chronic hepatitis 1.2
pancreatic cancer 1.2
mole 1.1
squamous cell carcinoma 1.1
malaria 1.1
adenocarcinoma 1.0
dehydration 1.0
metabolic syndrome 1.0
virus infection 1.0
autoimmune disease 0.9
anemia 0.9
neuroblastoma 0.8
herpes simplex 0.7
cytomegalovirus 0.7
colon cancer 0.7
Hodgkin's disease 0.6
cold 0.6
liver disease 0.6
leukemia 0.6
fits 0.6
dysplasia 0.5
tumor 0.5
uterus 0.5
HIV 0.5
heart disease 0.5
acute myeloid leukemia 0.4
immunodeficiency 0.4
hepatitis B 0.3
osteoporosis 0.3
breast cancer 0.2
tumor progression 0.2
cancer 0.2
multiple sclerosis 0.1
diabetes 0.0
metastases -0.1
rheumatoid arthritis -0.2
colorectal cancer -0.2
pneumonia -0.2
Alzheimer's disease -0.2
tumorigenesis -0.3
prostate cancer -0.3
sepsis -0.3
schizophrenia -0.4
obesity -0.4
carcinogenesis -0.5
lung cancer -0.6
heart failure -0.6
lymphoma -0.6
asthma -0.8
ischemia -1.0
stroke -1.6
Symptom
autodigestion 8.2
hypoproteinemia 7.4
HSA 4.0
diarrhea 3.2
tremor 2.4
constipation 2.2
acidity 1.6
respiratory distress 1.3
abdominal pain 0.6
vomiting 0.6
pain -0.9
Drug
Sodium carbonate 9.8
Neocarzinostatin 8.8
Salmon calcitonin 8.0
Secretin 7.6
GNA 7.4
Lactase 7.4
Aprotinin 7.3
Dexon 7.2
AMC 6.9
KGF 6.6
Papain 6.4
Doxycycline 5.4
IL-11 5.4
TAT 5.3
CCL 5.2
Ranitidine 4.9
uPA 4.5
Fragment 4.3
Asn 4.3
lysine 4.3
L-tyrosine 4.3
ETA 4.1
Alanine 4.1
Gel 4.0
IFN-beta 4.0
Glucagon 3.7
DNase I 3.5
lactose 3.5
Biopolymers 3.5
CTX 3.1
CTX 3.0
CaCl2 2.9
CaCl2 2.9
CaCl2 2.8
EPA 2.7
Nephron 2.4
Ethanol 2.3
CTX 2.2
NADH 2.1
Dial 1.6
ampicillin 1.5
IL-2 0.7
Dermatol -2.5
Enzyme
enterokinase 15.5
mast cell protease 5 13.5
ADP-sugar pyrophosphatase 12.9
duodenase 12.9
oxidized PVA hydrolase 12.7
PVA dehydrogenase 12.2
yeast ubiquitin hydrolase 12.1
deuterolysin 11.0
neurosin 10.5
hepsin 10.3
hepsin 10.3
carboxyl proteinase 10.3
fibrolase 10.1
cyclomaltodextrinase 9.7
plasmepsin II 9.1
sucrase 8.7
matriptase 8.6
glycoprotease 8.6
sucrase-isomaltase 8.6
matriptase 8.6
tripeptidyl peptidase 8.4
jararhagin 8.2
3C protease 8.2
lactase 8.2
carboxypeptidase G2 8.0
mannosidase I 7.8
TDH 7.7
trehalase 7.7
histidase 7.7
trypsin 7.6
carboxypeptidase A 7.6
invertase 7.6
alpha-glucosidase 7.5
chymase 7.5
leucine aminopeptidase 7.4
meprin 7.4
HPI 7.3
disulfide reductase 7.1
acrosin 7.1
chymotrypsin 7.1
chitosanase 7.1
anthranilate synthase 7.1
guanylate kinase 7.0
alanine aminopeptidase 7.0
alcohol oxidase 7.0
dextranase 6.9
aminopeptidase A 6.8
endoproteinase Glu-C 6.8
chorismate mutase 6.7
lactic acid dehydrogenase 6.7
lactic acid dehydrogenase 6.6
lysostaphin 6.6
lysin 6.5
tryptase 6.4
PI-PLC 6.4
cathepsin B 6.3
cathepsin G 6.3
carboxypeptidase B 6.3
elastase 6.1
phenylalanine hydroxylase 6.1
glucoamylase 6.1
MCS 5.9
prolyl endopeptidase 5.9
plasmin 5.8
dipeptidyl peptidase IV 5.8
TSP-1 5.8
12-lipoxygenase 5.8
subtilisin 5.7
beta-secretase 5.7
MDP 5.7
ALDH 5.7
Pla 5.7
glutathione S-transferase 5.6
thromboplastin 5.5
alpha-amylase 5.5
pepsin 5.5
proprotein convertase 5.4
granzyme B 5.4
lipase 5.3
N-acetyltransferase 5.3
TAT 5.3
tissue kallikrein 5.2
carboxypeptidase Y 5.2
thrombin 5.0
TPP 5.0
deoxyribonuclease 5.0
MAT 5.0
alpha-mannosidase 5.0
kallikrein 5.0
PNGase F 4.9
deoxyribonuclease 4.9
CD10 4.9
papain 4.8
ribonuclease 4.8
ribonuclease 4.8
MMP-3 4.8
MAT 4.8
alkaline phosphatase 4.7
urokinase-type plasminogen activator 4.7
phospholipase A2 4.7
CD13 4.7
thermolysin 4.6
proteinase K 4.5
paraoxonase 4.5
MMP 4.5
ADH 4.4
transglutaminase 4.3
thioredoxin reductase 4.3
DNase 4.2
RNase 4.2
SPC 4.2
hexokinase 4.2
diaphorase 4.1
micrococcal nuclease 4.1
ornithine decarboxylase 3.9
ricin 3.9
RNase 3.9
beta-glucosidase 3.8
prostate-specific antigen 3.8
beta-galactosidase 3.7
cathepsin D 3.5
phosphoenolpyruvate carboxykinase 3.5
phosphoenolpyruvate carboxykinase 3.5
aldehyde dehydrogenase 3.4
aldehyde dehydrogenase 3.4
PAH 3.4
aldehyde dehydrogenase 3.4
tyrosinase 3.4
ERK 3.4
hyaluronidase 3.4
phosphoenolpyruvate carboxykinase 3.3
kinesin 3.2
chloramphenicol acetyltransferase 3.2
deaminase 3.2
aldehyde dehydrogenase 3.2
RNA polymerase 3.0
hyaluronidase 2.9
aldehyde dehydrogenase 2.9
GSK 2.8
ATP synthase 2.7
lysozyme 2.7
tyrosine hydroxylase 2.7
MAP 2.7
carbonic anhydrase 2.7
APC 2.5
gamma-glutamyl transpeptidase 2.4
phospholipase C 2.4
alcohol dehydrogenase 2.3
transcriptase 2.3
adenylate cyclase 2.3
tissue plasminogen activator 2.1
caspase-3 2.0
peroxidase 1.8
lactate dehydrogenase 1.7
reverse transcriptase 1.6
calcineurin 1.5
ACE 1.4
collagenase 1.4
luciferase 1.3
protein kinase 1.2
catalase 0.8
superoxide dismutase 0.7
ACS 0.3
ATPase -0.5
mitogen-activated protein kinase -1.0
Compound
6-Methyluracil 12.4
Hexamethyldisiloxane 11.8
Diphenoxylate 11.7
Prephenate 10.0
Diisopropyl fluorophosphate 9.4
Benzamidine 9.4
Ectoine 9.1
NTA 9.1
BDH 8.8
Neocarzinostatin 8.8
HEP 8.6
Chloramine-T 8.6
Heptachlor 8.0
MUA 8.0
TNB 7.9
Thioredoxin 7.6
Trypsin 7.6
Secretin 7.5
ADP-glucose 7.5
Glu-Glu 7.4
DMB 7.4
DEX 7.3
BEP 7.3
E-64 7.2
DMB 7.1
Gliotoxin 7.0
IDA 6.9
Pentagastrin 6.9
carbonic acid 6.7
DTP 6.7
Factor X 6.6
Coomassie Blue 6.6
Melittin 6.5
carbonic acid 6.5
3-hydroxybutyric acid 6.4
CHAPS 6.3
Neomycin 6.2
Nordihydroguaiaretic acid 6.2
Asp 6.1
Histidine 6.0
His 6.0
DPC 5.9
DPC 5.9
TAP 5.8
nickel 5.8
HIS 5.8
MAL 5.7
Elastin 5.7
Agar 5.5
GAP 5.5
Doxycycline 5.5
DEAE 5.5
Hydroxyproline 5.4
lysine 5.4
serine 5.3
Heparan sulfate 5.3
PMSF 5.1
Thrombin 5.0
Thyroxine 5.0
DPPC 4.9
Gly 4.9
SDS 4.9
DPPC 4.9
PLP 4.8
Phosphatidylcholine 4.8
SOA 4.8
Serine 4.8
EDC 4.7
LPC 4.7
ANCA 4.7
D-Ala 4.6
aspartic acid 4.6
Cytochrome c 4.6
PMA 4.5
aspartic acid 4.5
Ile 4.5
aspartic acid 4.5
COS 4.5
Triton 4.5
arginine 4.4
TOF 4.4
Parenteral 4.3
PNA 4.3
Arachidonic acid 4.2
alanine 4.2
Triton X-100 4.2
aspartic acid 4.2
PAR 4.2
hydroxylamine 4.2
Alanine 4.1
PAP 4.1
hydroxylamine 4.1
cysteine 4.0
ADP-ribose 4.0
ETA 4.0
PAC 4.0
guanidine 4.0
PAP 3.9
PAP 3.9
Phe 3.9
PAP 3.8
ornithine 3.8
ornithine 3.8
ornithine 3.8
ornithine 3.8
ornithine 3.8
Glucagon 3.7
DDP 3.6
Luminal 3.6
PAM 3.6
PAM 3.6
Congo red 3.6
NH2 3.6
PVA 3.4
PNP 3.4
PAH 3.4
methionine 3.4
PGA 3.3
betaine 3.3
Histone 3.3
urea 3.3
leucine 3.2
sulfate 3.2
EDTA 3.1
EDTA 3.1
APAP 3.1
KOH 3.1
threonine 3.1
glutamic acid 3.1
cyclohexane 3.1
2-hydroxyethyl 3.1
Optimal 3.0
asparagine 3.0
piperidine 2.9
piperidine 2.9
PLA 2.9
propionic acid 2.9
propionic acid 2.9
A 1 2.9
Diazepam 2.9
proline 2.9
CaCl2 2.9
Curcumin 2.9
NAD 2.8
Heparin 2.8
NAD 2.8
GlcNAc 2.8
HCl 2.8
Ang II 2.8
tyrosine 2.8
tryptophan 2.7
tryptophan 2.7
EPA 2.7
salt 2.7
Hemoglobin 2.7
6-12 2.7
tryptophan 2.7
xylose 2.7
tryptophan 2.5
aniline 2.5
alcohol dehydrogenase 2.5
acrylamide 2.5
methanol 2.5
bromide 2.5
Salt 2.5
fluorine 2.4
hexose 2.4
Tris 2.4
CAT 2.4
CAT 2.4
GMP 2.4
sodium 2.3
cobalt 2.3
Sodium 2.3
Estrogen 2.3
CAT 2.3
GTP 2.3
glycerol 2.2
CTX 2.2
TNF 2.2
isoleucine 2.2
Tris 2.2
Estrogen 2.2
isoleucine 2.2
AMP 2.2
ammonium 2.2
NADH 2.1
naphthalene 2.0
TEM 2.0
galactose 1.9
ADP 1.9
ADP 1.9
zinc 1.9
calcium 1.8
glutamine 1.8
Insulin 1.7
ADP 1.7
PGE2 1.7
valine 1.7
iron 1.6
Pac 1.5
ethanol 1.4
glutamate 1.4
vinyl 1.4
chloroform 1.3
cAMP 1.3
acetate 1.3
ACTH 1.3
MIC 1.2
acetone 1.1
DNA 1.1
glucose 1.0
NADPH 0.9
NADPH 0.9
PEG 0.7
phosphate 0.7
silver 0.7
H2O2 0.6
potassium 0.6
MTT 0.5
ATP 0.5
cadmium 0.4
acetic acid 0.4
ACS 0.3
PEG 0.3
ACS 0.3
ammonia 0.1
Dec -0.1
hydrogen -0.5
Clin -0.6
nitrogen -0.7
water -0.9
nitric oxide -1.1
oxygen -1.4