Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.73 (
urokinase-type plasminogen activator
)
10,685
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
urokinase-type plasminogen activator
9466
plasminogen
2854
PLA
2635
urokinase plasminogen activator
1175
plasminogen activator inhibitor-1
1174
uPAR
1007
plasminogen activator inhibitor
821
Sep
717
tissue plasminogen activator
713
thrombin
606
fibrinogen
590
Plasminogen
576
u-PA
528
Mol
511
serine protease
447
matrix metalloproteinase
406
MMP-9
371
collagen
335
MMP-2
332
tPA
320
vitronectin
292
PAI-2
275
SDS
246
fibronectin
245
vascular endothelial growth factor
198
Plasmin
188
inhibitor-1
182
PAR
164
PAI
161
epidermal growth factor
154
cytokine
146
kallikrein
144
hepatocyte growth factor
142
metalloproteinase
130
ERK1
129
tissue factor
128
urokinase plasminogen activator receptor
119
CD87
118
EPA
116
ERK
115
more...
Disease
cancer
1865
tumor
1689
breast cancer
562
metastases
372
carcinoma
367
acute myocardial infarction
309
tumor growth
255
tumor progression
253
SDS
246
myocardial infarction
215
stroke
212
prostate cancer
208
melanoma
199
pulmonary embolism
194
ischemia
171
deep vein thrombosis
134
adenocarcinoma
130
ovarian cancer
126
MCF
117
hepatocellular carcinoma
116
atherosclerosis
115
lung cancer
104
SCID
102
carcinogenesis
92
squamous cell carcinoma
89
diabetes
87
fibrosarcoma
87
gastric cancer
86
colon cancer
85
colorectal cancer
82
glioma
80
lung carcinoma
78
tumorigenesis
77
primary tumor
76
plaque
76
glioblastoma
74
hypertension
72
leukemia
66
disseminated intravascular coagulation
65
sepsis
61
more...
Symptom
pain
68
angina
61
chest pain
58
dyspnea
28
anesthesia
27
respiratory distress
20
abdominal pain
17
functional recovery
15
headache
15
seizures
15
spasm
14
vomiting
11
flushing
11
cyanosis
10
hemiplegia
10
collapse
10
syncope
9
weakness
9
flank pain
7
hyperoxia
7
consciousness disturbance
7
exertional dyspnea
7
starvation
6
paresis
6
dysarthria
6
hypothermia
6
shortness of breath
6
nausea
6
lethargy
4
tachypnea
4
hemoptysis
4
stigma
4
thinning
4
exhaustion
4
paraparesis
4
back pain
4
fatigue
3
hypocapnia
3
asynergy
3
HSA
3
more...
Drug
uPA
1874
Urokinase
388
lysine
298
Cardiovasc
162
Dermatol
93
Streptokinase
57
CSF
44
Gel
31
DFP
28
CTA
27
Aprotinin
25
Alteplase
24
Alteplase
23
Alteplase
22
IFN-gamma
21
Amiloride
20
Gelatin
20
MAP
20
Amiloride
20
Asn
20
nitroglycerin
17
Norplant
14
Nephron
13
Dial
13
Nephron
13
CaCl2
12
CaCl2
12
CaCl2
12
ROS
11
CAM
10
GEO
10
DDAVP
9
Ancrod
9
EE2
9
ETS
9
DDAVP
9
vitamin E
8
ABC
8
G-CSF
8
Ringer's solution
8
more...
Enzyme
urokinase-type plasminogen activator
10685
tissue plasminogen activator
2035
plasmin
2013
thrombin
590
mitogen-activated protein kinase
342
trypsin
337
ERK
246
collagenase
226
kallikrein
199
thromboplastin
150
protein kinase C
138
APC
121
MMP-3
115
MMP
107
focal adhesion kinase
105
elastase
94
chymotrypsin
94
protein kinase
91
MEK
90
matrix metalloproteinase 2
82
cathepsin B
79
matrix metalloproteinase 9
67
cathepsin D
57
phospholipase C
54
neutrophil elastase
52
creatine kinase
38
tissue kallikrein
37
reverse transcriptase
36
phosphatidylinositol 3-kinase
36
cathepsin G
35
matriptase
35
matriptase
33
caspase-3
32
luciferase
32
peroxidase
31
alkaline phosphatase
29
cathepsin L
28
AMPK
23
catalase
23
tryptase
21
more...
Compound
Dec
740
serine
527
Clin
513
lysine
419
DNA
408
arginine
336
sodium
281
SDS
263
sulfate
224
acetate
221
MDA
209
Plasmin
179
PAR
164
Cardiol
147
calcium
142
tyrosine
135
Gly
125
cysteine
112
oxygen
110
Fibrin
105
alanine
103
Phe
96
methionine
91
leucine
84
cAMP
82
water
80
Heparin
78
glucose
76
Thrombin
76
NH2
75
retinoic acid
67
TNF
67
His
66
ACS
61
PMA
58
Asp
58
ASA
57
phosphate
57
PMA
55
ATF
49
more...