Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
urokinase-type plasminogen activator 9466
plasminogen 2854
PLA 2635
urokinase plasminogen activator 1175
plasminogen activator inhibitor-1 1174
uPAR 1007
plasminogen activator inhibitor 821
Sep 717
tissue plasminogen activator 713
thrombin 606
fibrinogen 590
Plasminogen 576
u-PA 528
Mol 511
serine protease 447
matrix metalloproteinase 406
MMP-9 371
collagen 335
MMP-2 332
tPA 320
vitronectin 292
PAI-2 275
SDS 246
fibronectin 245
vascular endothelial growth factor 198
Plasmin 188
inhibitor-1 182
PAR 164
PAI 161
epidermal growth factor 154
cytokine 146
kallikrein 144
hepatocyte growth factor 142
metalloproteinase 130
ERK1 129
tissue factor 128
urokinase plasminogen activator receptor 119
CD87 118
EPA 116
serine protease inhibitor 115
ERK 115
tumor necrosis factor 114
VEGF 113
p38 111
casein 111
collagenase 109
MMP-1 108
glycoprotein 106
albumin 103
insulin 98
MAPK 98
MMP 93
E-cadherin 93
matrix metalloproteinase 2 92
nexin 91
prothrombin 91
cell surface receptor 91
AP-1 89
antithrombin III 89
polypeptide 89
factor Xa 88
chymotrypsin 85
TIMP-2 85
MMP9 82
p53 82
TGF-beta 80
cathepsin B 79
lipopolysaccharide 74
thromboplastin 74
trypsin inhibitor 73
transforming growth factor-beta 72
MMP-3 71
PC-3 69
fused 69
plasminogen activator inhibitor 2 69
stromelysin 68
TNF 67
tyrosine kinase 66
antithrombin 65
protein C 65
bradykinin 64
protease inhibitor 64
alpha 2-plasmin inhibitor 63
EGF 63
cathepsin D 62
PI3K 59
lipoprotein receptor-related protein 59
She 58
HT-1080 58
epidermal growth factor receptor 58
IL-6 57
IL-8 55
membrane-bound 55
estrogen receptor 54
MEK 54
AKT 53
c-Jun 51
MT1-MMP 50
ATF 49
von Willebrand factor 49
vimentin 48
JNK 48
HGF 48
Met 48
extracellular signal-regulated kinase 47
factor XII 47
osteosarcoma 47
TNF-alpha 46
focal adhesion kinase 46
PCI 46
MMP2 45
p65 45
TPA 45
membrane protein 45
EGFR 45
PLAU 45
osteopontin 44
HER2 44
serum albumin 43
GPI 41
platelet-derived growth factor 41
PC3 41
ECM 41
tissue inhibitor of metalloproteinases 41
HNE 41
Tissue plasminogen activator 40
thrombomodulin 39
heavy chain 39
nodal 38
caspase-3 38
cyclin D1 38
interleukin-6 38
vascular endothelium 38
c-Met 38
interferon 38
LRP 38
scatter factor 37
beta 1 37
Rho 37
chemokine 37
metalloprotease 37
proliferating cell nuclear antigen 37
IL-1 37
LPS 37
thrombospondin 37
FGF 36
FAK 36
matriptase 36
phosphatidylinositol 3-kinase 36
NMR 36
alpha2-macroglobulin 36
low-density lipoprotein receptor 36
PK1 35
AMP 35
Mal 35
THP 35
progesterone receptor 35
ADP 34
matrix metalloprotease 34
PKC 34
more...
Disease
cancer 1865
tumor 1689
breast cancer 562
metastases 372
carcinoma 367
acute myocardial infarction 309
tumor growth 255
tumor progression 253
SDS 246
myocardial infarction 215
stroke 212
prostate cancer 208
melanoma 199
pulmonary embolism 194
ischemia 171
deep vein thrombosis 134
adenocarcinoma 130
ovarian cancer 126
MCF 117
hepatocellular carcinoma 116
atherosclerosis 115
lung cancer 104
SCID 102
carcinogenesis 92
squamous cell carcinoma 89
fibrosarcoma 87
diabetes 87
gastric cancer 86
colon cancer 85
colorectal cancer 82
glioma 80
lung carcinoma 78
tumorigenesis 77
plaque 76
primary tumor 76
glioblastoma 74
hypertension 72
leukemia 66
disseminated intravascular coagulation 65
sepsis 61
pancreatic cancer 59
Thrombus 58
proteinuria 56
osteosarcoma 53
sepsis 52
rheumatoid arthritis 50
tumor angiogenesis 49
HGF 48
aggressiveness 48
epithelial ovarian cancer 45
coronary artery disease 41
heart failure 41
non-small cell lung cancer 40
uterus 40
thrombocytopenia 40
renal disease 39
SEM 39
glomerulosclerosis 39
empyema 39
Alzheimer's disease 39
arthritis 38
infectious diseases 36
Infection 36
obesity 36
cerebral infarction 36
osteoarthritis 35
nephrotic syndrome 35
cardiovascular disease 34
coronary thrombosis 33
pneumonia 33
lung metastases 32
cerebral ischemia 32
HIV 31
pulmonary fibrosis 31
unstable angina 30
cirrhosis 30
glomerulonephritis 30
metastatic breast cancer 29
multiple myeloma 29
hepatitis C 29
mammary tumor 28
sarcoma 28
brain tumor 27
renal cell carcinoma 27
cornea 27
pertussis 26
preeclampsia 26
neuroblastoma 26
systemic lupus erythematosus 26
glioblastoma multiforme 26
depression 26
acute myeloid leukemia 24
anthrax 24
myocardial ischemia 24
lymphoma 24
bladder cancer 24
hepatitis B 24
hydrocephalus 23
peritonitis 23
endometrial cancer 23
liver fibrosis 22
liver disease 22
Adhesion 21
Blocking 21
cervical cancer 21
coma 20
renal failure 20
coagulopathy 20
coronary occlusion 19
adenoma 19
vascular disease 19
subarachnoid hemorrhage 19
nephritis 19
liver cancer 19
immunodeficiency 19
meningioma 19
congestive heart failure 18
Melanoma 18
HRA 17
pemphigus 17
Placenta 17
hyperglycemia 16
pulmonary hypertension 16
multiple sclerosis 16
oral cancer 16
endometriosis 16
solid tumor 16
asthma 16
chronic renal failure 16
Dukes 16
meningitis 16
cholera 16
platelet disorder 15
mole 15
lupus 15
gangrene 14
invasive cancer 14
idiopathic pulmonary fibrosis 14
liver metastases 14
dysplasia 14
suicide 14
diabetic nephropathy 14
liver cancer 14
arteriosclerosis 14
periodontitis 13
astrocytoma 13
heart disease 13
bone metastases 13
virus infection 13
bacteremia 13
cytomegalovirus 13
psoriasis 13
acute promyelocytic leukemia 13
vasculitis 12
coronary heart disease 12
AGS 12
GFD 12
lung disease 12
papilloma 12
adult respiratory distress syndrome 12
more...
Symptom
pain 68
angina 61
chest pain 58
dyspnea 28
anesthesia 27
respiratory distress 20
abdominal pain 17
seizures 15
functional recovery 15
headache 15
spasm 14
vomiting 11
flushing 11
collapse 10
hemiplegia 10
cyanosis 10
syncope 9
weakness 9
consciousness disturbance 7
flank pain 7
hyperoxia 7
exertional dyspnea 7
starvation 6
dysarthria 6
nausea 6
hypothermia 6
shortness of breath 6
paresis 6
tachypnea 4
stigma 4
hemoptysis 4
exhaustion 4
thinning 4
paraparesis 4
back pain 4
lethargy 4
diarrhea 3
HSA 3
tremor 3
disturbed balance 3
acute abdominal pain 3
acidity 3
discomfort 3
fatigue 3
vertigo 3
hypercapnia 3
discomfort 3
asynergy 3
regurgitation 3
epigastric pain 3
hypocapnia 3
numbness 3
neurological disability 2
cough 2
rhinorrhea 2
sleepiness 2
oliguria 2
Ill 2
insomnia 2
erythema 2
nausea and vomiting 2
analgesia 2
overweight 2
autodigestion 2
chills 2
low back pain 2
neck pain 2
pallor 2
agitation 2
nasal discharge 1
Decreased activity 1
swollen leg 1
paresthesia 1
anosmia 1
intestinal bleeding 1
pelvic pain 1
loss of balance 1
wrist pain 1
dysuria 1
acute stress 1
bradykinesia 1
Fluctuation 1
hypersomnia 1
right upper quadrant pain 1
facial droop 1
blurred vision 1
ataxia 1
abdominal fullness 1
excessive sweating 1
Dull pain 1
finger pain 1
chest tightness 1
hepatosplenomegaly 1
myalgia 1
livedo 1
neck stiffness 1
Scratch 1
acute pain 1
hypoproteinemia 1
bone pain 1
skin damage 1
dry skin 1
cachexia 1
leg pain 1
rigors 1
menopausal symptoms 1
hemihypesthesia 1
Pain at rest 1
dysesthesia 1
general problem 1
Refractory angina pectoris 1
splenomegaly 1
hypalgesia 1
groin pain 1
Drug
uPA 1874
Urokinase 388
lysine 298
Cardiovasc 162
Dermatol 93
Streptokinase 57
CSF 44
Gel 31
DFP 28
CTA 27
Aprotinin 25
Alteplase 24
Alteplase 23
Alteplase 22
IFN-gamma 21
Gelatin 20
Amiloride 20
Asn 20
Amiloride 20
MAP 20
nitroglycerin 17
Norplant 14
Nephron 13
Nephron 13
Dial 13
CaCl2 12
CaCl2 12
CaCl2 12
ROS 11
CAM 10
GEO 10
DDAVP 9
DDAVP 9
ETS 9
EE2 9
Ancrod 9
CCL 8
vitamin E 8
ABC 8
G-CSF 8
Ringer's solution 8
Batimastat 7
Angiotensin II 7
ROC 7
Adriamycin 7
Fluorescein 7
Batimastat 7
DNase I 7
Antithrombin III 6
Coumadin 6
Fluorescein 6
ACT 5
ascorbate 5
Leaf 5
Fragment 5
G418 5
Alanine 5
IL-2 5
Portal 4
Dalteparin 4
Retinoic acid 4
FeCl3 4
Herceptin 4
MRC 4
Captopril 4
TAT 4
Indomethacin 4
Activase 4
Abciximab 4
Monit 4
KGF 4
Cibacron Blue 3
Cetrorelix 3
TTC 3
AMC 3
Bayer 3
Gabexate mesilate 3
BLM 3
Tenecteplase 3
Bevacizumab 3
PCP 3
PTH 3
ICI 3
Lovastatin 3
p75 3
Ethanol 3
Simvastatin 3
Gefitinib 3
Forskolin 3
Levonorgestrel 3
TAC 3
Glycyrrhiza 3
lactose 3
NAG 2
KAN 2
Zoledronic acid 2
Heme 2
Clopidogrel 2
balanced salt solution 2
Heparin sodium 2
Glucagon 2
CoCl2 2
L-tyrosine 2
Dihydrotestosterone 2
Glycerol 2
CTX 2
Erlotinib 2
Hyperforin 2
CoCl2 2
ZnCl2 2
Fraction 2
Argatroban 2
Iloprost 2
ampicillin 2
Award 2
Paraffin 2
Marimastat 2
Panitumumab 2
Aloe 2
Prednisolone 2
CPZ 2
PTC 2
CTX 2
Methylprednisolone 2
NBT 2
AGG 2
ZnCl2 2
Zoledronic acid 2
CTX 2
ENT 1
caffeine 1
Prolyse 1
Norplant 1
Lipiodol 1
Desmoteplase 1
Diphenhydramine 1
Capravirine 1
NADH 1
Doxycycline 1
TiO2 1
Bestatin 1
Lanoteplase 1
Leucovorin 1
Activin 1
DMAP 1
Compound 15 1
Dihydro 1
Mutagen 1
Esberiven 1
Check 1
Sorafenib 1
Orlistat 1
CEC 1
L-Homoarginine 1
Allergen 1
Taxol 1
Guanidine 1
DHT 1
Tannic acid 1
Mycophenolic acid 1
more...
Enzyme
urokinase-type plasminogen activator 10685
tissue plasminogen activator 2035
plasmin 2013
thrombin 590
mitogen-activated protein kinase 342
trypsin 337
ERK 246
collagenase 226
kallikrein 199
thromboplastin 150
protein kinase C 138
APC 121
MMP-3 115
MMP 107
focal adhesion kinase 105
elastase 94
chymotrypsin 94
protein kinase 91
MEK 90
matrix metalloproteinase 2 82
cathepsin B 79
matrix metalloproteinase 9 67
cathepsin D 57
phospholipase C 54
neutrophil elastase 52
creatine kinase 38
tissue kallikrein 37
reverse transcriptase 36
phosphatidylinositol 3-kinase 36
cathepsin G 35
matriptase 35
matriptase 33
luciferase 32
caspase-3 32
peroxidase 31
alkaline phosphatase 29
cathepsin L 28
AMPK 23
catalase 23
tryptase 21
interstitial collagenase 21
papain 20
renin 20
prostate-specific antigen 19
ancrod 19
lactate dehydrogenase 19
adenylate cyclase 17
ACE 16
CD10 16
furin 15
proteasome 15
thermolysin 15
transglutaminase 14
IKK 14
RNase 13
subtilisin 13
phosphoinositide 3-kinase 13
hepsin 13
superoxide dismutase 13
hepsin 13
glutathione S-transferase 13
ACS 13
pepsin 13
neuraminidase 13
lipoprotein lipase 13
enolase 12
thrombin-activatable fibrinolysis inhibitor 12
RNA polymerase 12
chloramphenicol acetyltransferase 12
phospholipase A2 12
RNase 12
deaminase 12
dipeptidyl peptidase IV 11
ATPase 11
aspartate aminotransferase 11
calcineurin 11
carboxypeptidase B 11
MEKK1 11
MAP 11
PARP 10
alanine aminotransferase 9
glyceraldehyde-3-phosphate dehydrogenase 9
hyaluronidase 9
transcriptase 8
heparinase 8
glyceraldehyde-3-phosphate dehydrogenase 8
PTA 8
macrophage elastase 8
sialidase 8
beta-galactosidase 8
Hageman factor 8
lysozyme 8
phosphodiesterase 8
cdc2 8
thymidine kinase 7
carboxylesterase 7
stromelysin-3 7
NADPH oxidase 7
chymase 7
lipoxygenase 7
caspase-9 7
DNase 6
PNGase F 6
TSP-1 6
NADPH oxidase 6
chondroitinase 6
CD13 6
chondroitinase 6
glyceraldehyde-3-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
acetylcholinesterase 6
aldehyde dehydrogenase 6
enterokinase 6
glyceraldehyde-3-phosphate dehydrogenase 6
GSK 6
5'-nucleotidase 6
acrosin 6
thymidine phosphorylase 5
fumarylacetoacetate hydrolase 5
NO synthase 5
prostasin 5
acid phosphatase 5
phospholipase D 5
MIP 5
PI-PLC 5
CYP3A4 5
histidase 5
GAS 4
AMP-activated protein kinase 4
proteinase K 4
MDP 4
MAT 4
AST 4
hyaluronidase 4
TAT 4
prostate-specific membrane antigen 4
aldehyde oxidase 4
HCS 4
E-2 4
dihydrofolate reductase 4
cholinesterase 4
MAT 4
cathepsin C 4
S1 nuclease 4
ribonuclease 3
ornithine decarboxylase 3
asparaginase 3
firefly luciferase 3
protein phosphatase 2A 3
carboxypeptidase A 3
alpha-amylase 3
pyruvate kinase 3
cathepsin H 3
urease 3
CEP 3
xanthine oxidase 3
Pla 3
KLK7 3
phosphoglycerate kinase 3
choline acetyltransferase 3
more...
Compound
Dec 740
serine 527
Clin 513
lysine 419
DNA 408
arginine 336
sodium 281
SDS 263
sulfate 224
acetate 221
MDA 209
Plasmin 179
PAR 164
Cardiol 147
calcium 142
tyrosine 135
Gly 125
cysteine 112
oxygen 110
Fibrin 105
alanine 103
Phe 96
methionine 91
leucine 84
cAMP 82
water 80
Heparin 78
Thrombin 76
glucose 76
NH2 75
TNF 67
retinoic acid 67
His 66
ACS 61
Asp 58
PMA 58
phosphate 57
ASA 57
PMA 55
zinc 49
ATF 49
MEK 47
urea 47
threonine 46
Fibrinogen 44
ADP 40
Triton X-100 40
ammonium 39
MTT 39
prostacyclin 38
TPA 37
Ile 37
TPA 37
salt 37
THP 35
hydrogen 35
THP 35
AMP 35
Serine 35
EDTA 35
ADP 34
galactose 34
ADP 34
PEG 33
creatinine 33
ethanol 32
glutamic acid 32
EDTA 32
6-aminohexanoic acid 30
6-aminohexanoic acid 30
DEAE 29
copper 29
nitric oxide 29
FDP 29
guanidine 26
HCl 24
iodine 23
PEG 23
prostaglandin E1 21
Collagen 21
Amiloride 20
proline 20
nitrogen 19
Tranexamic acid 19
SCC 19
COS 18
potassium 17
CAT 17
methanol 17
MCA 16
thioglycollate 16
CAT 16
CAT 16
MCA 16
ATP 16
TNM 15
glycerol 15
Dexamethasone 15
tryptophan 15
Casein 15
Warfarin 15
bromide 14
aldehyde 14
PGE2 14
hyaluronic acid 14
Trypsin 13
iron 13
ACS 13
Dial 13
DIC 13
Phorbol 13
acrylamide 12
Optimal 12
MAP 12
silver 12
aldehyde 12
CaCl2 12
GTP 12
acetic acid 12
tryptophan 12
Tris 12
tryptophan 12
PMSF 12
tryptophan 12
H2O2 11
Curcumin 11
CAM 11
Estradiol 11
N-acetylcysteine 11
aspartic acid 11
Cysteine 11
aspartic acid 10
barium 10
Salt 10
nickel 10
glutamine 10
Adriamycin 10
aspartic acid 10
BLM 10
aspartic acid 10
TOF 10
MIA 9
Insulin 9
pyrimidine 9
Vimentin 9
pyrimidine 9
CO2 9
aminomethyl 9
Progesterone 9
Angiotensin II 9
Phosphatidylinositol 9
BRL 9
Genistein 9
homocysteine 8
retinol 8
DMSO 8
PGE 8
acetone 8
Z-Gly 8
hydroxylamine 8
more...