Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Angiogenesis is a complex phenomenon which includes at least four distinct properties of endothelial cells ECs; degradation of vascular basement membrane and interstitial matrices by proteases, migration, proliferation, and tube formation. We are studying the transcriptional regulation of angiogenesis. We observed that angiogenic growth factors including VEGF and bFGF induced transcription factor ETS-1 in ECs, and ETS-1 converts ECs to angiogenic phenotype by inducing u-PA, MMP-1, MMP-3, MMP-9, and integrin beta 2 as target genes. The elimination of the expression of ETS-1 in ECs inhibited angiogenesis. These results indicate that ETS-1 can be a molecular target for the regulation of angiogenesis.
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PMID:Transcription factor ETS-1 as a molecular target for angiogenesis inhibition. 1036 58

suPLAUR is the transcript variant that encodes the soluble form of the urokinase plasminogen activator surface receptor (suPLAUR). This soluble protein has been shown to enhance leukocyte migration and adhesion, and its circulatory level is increased in inflammatory states. In this pilot study, we used RNA-Seq to examine the splicing pattern of PLAUR in omental adipose tissues from obese and lean individuals. Of the three transcript variants of the PLAUR gene, only the proportion of suPLAUR (transcript variant 2) increases in obesity. After removing the effects of gender and age, the expression of suPLAUR is positively correlated with body mass index. This observation was validated using RT-qPCR with an independent cohort of samples. Additionally, in our RNA-Seq differential expression analysis, we also observed, in obese adipose tissues, an up-regulation of genes encoding other proteins involved in the process of chemotaxis and leukocyte adhesion; of particular interest is the integrin beta 2 (ITGB2) that is known to interact with suPLAUR in leukocyte adhesion. These findings suggest an important role for suPLAUR in the recruitment of immune cells to obese adipose tissue, in the pathogenesis of obesity.
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PMID:The mRNA expression of soluble urokinase plasminogen activator surface receptor in human adipose tissue is positively correlated with body mass index. 2628 4