Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.73 (
urokinase-type plasminogen activator
)
10,685
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Focal adhesion components are targets for biochemical and mechanical stimuli that evoke crucial injury.
Hic-5
(hydrogen peroxide-inducible clone 5) is a multidomain adaptor protein which is implicated in the regulation of integrin signaling in focal adhesion. The aim of this research was to test the hypothesis that
Hic-5
, a focal adhesion LIM protein expressed in smooth muscle cells, is involved in dynamic processes by pathological stimuli in the vessel wall. Here, we describe the analysis of the function of
Hic-5
using a mouse model of vascular injury that may mimic balloon angioplasty. At 4 days after vascular injury, marked down-regulation of the
Hic-5
expression was observed in the smooth muscle layer, and local delivery of the
Hic-5
using adenovirus vectors repressed injury-induced neointimal expansion. In addition,
Hic-5
reduced cells migration into three-dimensional collagen gels, and the forced expression of
Hic-5
in cells embedded in the collagen gel matrix repressed the expression of
uPA
that participates in smooth muscle cell migration. These results suggest that
Hic-5
modulates cellular responses to pathological stimuli in the vessel wall.
...
PMID:Hic-5, an adaptor protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. 1881 62
