Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study, the frequency of cilium movement was measured by a photoelectric method at various sites in the human oviduct. The studies were performed to examine a possible difference between right and left oviducts, age-related differences, changes due to the menstrual cycle and pregnancy, and the effects of various drugs such as antibiotics, urokinase and corticosteroid (prednisolone). The results are summarized as follows: The frequency of cilium movement was 435.4 +/- 102.8 at the isthmus, 599.6 +/- 97.2 at the ampulla tubae, and 626.8 +/- 106.7 at the fimbriae, showing significant differences (p less than 0.05). However, no difference between the frequency in the right and left oviducts was detected. Number of cilia and/or ciliary cells changed periodically. The frequency of cilium movement appeared to increase in the late follicular phase as compared to both the early follicular phase and the luteinizing phase. This tendency was marked in the fimbriae. However, statistical analysis revealed no clear significance. No age-related differences were observed in the ciliary movements. Even after menopause, the ciliary movements could be observed. It was found that the ciliary movements decreased in pregnancy. Both PcG and CET inhibited the ciliary movements. Prednisolone at a concentration of 4.62 mg/ml inhibited the movement and even at 25 mg/ml did so at 90 min after the treatment. Urokinase did not inhibit the movements but rather stimulated the ciliary movements.
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PMID:[Cilium movement of human oviduct]. 359 73

A 68-year-old woman first noticed Raynaud's phenomenon at the age of 35, and she was diagnosed as having systemic sclerosis (SSc) because of cutaneous calcinosis, sclerodactyly, telangiectasia, sausage-like finger, digital pitting scar in 1971. In October, 1994, she was suffered from cold sensation in her right foot, and on November 2 she noticed the painful ulcers on the right toe, which progressed to be gangrenous. Every antiplatelet or thrombolytic agents including PGE1, argatroban, sarpogrelate hydrochloride and urokinase were unsuccessful. Angiograms revealed marked narrowing of bilateral anterior and posterior tibial and peroneal arteries. Prednisolone 30 mg/day was started, which resulted in successful response within 10 days. Large vessel involvement in SSc patients has been reported to be rare, and its treatment remains to be established. We believe our case help understanding the pathophysiology of such rare manifestation in SSc.
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PMID:[Successful treatment of toe gangrene with moderate-dose steroid therapy in a patient with systemic sclerosis (CREST syndrome)]. 925 35