Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.73 (
urokinase-type plasminogen activator
)
10,685
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There have been reports of strong correlations between poor prognosis in various cancers and concomitant expression of
urokinase-type plasminogen activator
(
uPA
) and its surface receptor (uPAR). We and others have previously shown that the
uPA
system plays a significant role in a subset of head and neck squamous cell carcinoma. In the present study, we found that uPAR is required for invasion and metastasis of highly malignant oral cancer cells (
OSC
-19). Treating
OSC
-19 cells with antisense oligonucleotides (AS) targeting uPAR resulted in a dramatic decrease of uPAR mRNA expression. Furthermore, pretreatment with AS or siRNA targeting uPAR inhibited progression of
OSC
-19 cells in experimental models. These results suggest that overexpression of uPAR increases the invasiveness and metastasis of
OSC
-19 cells, and that uPAR is a promising therapeutic target for regulation of progression of oral cancer.
...
PMID:Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor. 1612 56
