Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The acute respiratory distress syndrome being a critical complication of septic shock limits the patient's survival. A significant advance in treatment is the use of positive end-expiratory pressure ventilation (PEEP). As microthrombosis of the lung microcirculation seems to be one of the pathogenetic factors of RDS, fibrinolytic treatment may be tried as an additional therapeutic possibility, even in life-threatening situations. In this case we report on the treatment of shock lung resulting from septic shock occurring after diagnostic amniocentesis in the 16th week of pregnancy, this being a rare complication. By applying the principles of treatment described above --"Super PEEP" with 20 cm H2O and fibrinolysis with urokinase despite the presence of absolute contraindications--the respiratory insufficiency could be controlled.
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PMID:[Intensive care of acute respiratory distress syndrome in septic shock--a case report (author's transl)]. 699 68