Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors analyse experience in the use of the synthetic analogue of ++leu enkephalin dalargin in multicomponent balanced anesthesia in operations on the abdominal organs in 36 patients. With the use of the suggested method the intraoperative expenditure of narcotic analgesics is 6 times less but the efficacy of the anesthesia remains the same. Study of the activity of the liver-specific enzymes (histidase and urokinase) in blood plasma and biopsy material taken from the liver and the content of malonic dialdehyde in the hepatic biopsy specimen revealed hepatoprotective properties of dalargin. The decrease of the total peripheral resistance and increase of the elasticity of the arterial reservoir++ in the main group as compared to these values in patients treated by the traditional method were considered by the authors to be the consequence of the autonomic priming effect of the opiopeptide used. It is concluded that the use of synthetic analogues of endogenous opioids (dalargin) in the anesthesiological protection complex in operations on the abdominal organs is expedient.
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PMID:[Use of dalargin in complex anesthesiological protection during operations on the abdominal organs]. 223 89

The influence of diazepam, droperidol, fentanyl and central transcutaneous electrical stimulation (ES) on hepatocytes was studied in experiments on healthy rats (group I). Organospecific enzymes (histidase and urokinase) were chosen for the evaluation of side effects of drugs and their combination with ES on physiological functions of the liver. Drugs and their combinations with ES used in the clinical practice caused no marked damage of hepatocytes in healthy animals. A pronounced decrease in the above enzyme activity (3-fold, as compared to the control group) was revealed in rats with acute cholestasis and pancreatitis 72 h after ES. This fact shows hepatoprotective effects of ES. The most marked unfavourable effect on hepatocytes was registered in group II, where fentanyl was used.
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PMID:[Effect of the components of electro-drug anesthesia and ataralgesia on the appearance of hepato-specific enzymes in the blood]. 349 74

Phenazepame exhibited properties of prooxidant in a model system of oleic acid methyl ester oxidation. After single intraperitoneal administration of phenazepame (5 mg/kg) the antioxidative activity (AOA) of rat liver lipids was decreased, correlating with level of histidase and urokinase activity in blood plasma indicating the liver tissue injury. Distinct alterations in the relative content of liver phospholipids were also noted. A phase type of alterations was observed in the content of these phospholipids as well as in the ratio phosphatidyl choline/phosphatidyl ethanolamine; at the same time, the phospholipid ratio was altered simultaneously with the alterations of the enzymatic activities in blood. After administration of the antioxidant, which normalized the AOA level and the phospholipid composition, activities of histidase and urokinase were markedly decreased in blood. The neuroleptanalgetic drug thalamonale, protecting liver tissue against the impairments, normalized the AOA level and the phospholipid composition. Thus, alterations in AOA and in the phospholipid composition reflected distinctly the unfavourable effect of phenazepame as well as the protecting action of thalamonale on liver tissue.
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PMID:[The role of changes in the antioxidative activity and phospholipid composition of the rat liver in the mechanism of phenazepam action on the liver and the protective effect of talamonal]. 402 26

Liver tissue specific enzymes histidase and urokinase were found in blood of 160 rats after intraperitoneal administration of phenazepam at the doses of 1.0 and 2.5 mg/200 g of body weight as well as of diazepam at the dose of 2.0 mg/200 g. Administration of products of diazepam enzymatic degradation caused also the liberation of these enzymes from liver tissue into blood.
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PMID:[Effect of phenazepam and seduxen on the presence of histidase and urokinase in the blood]. 667 Feb 24