Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.73 (
urokinase-type plasminogen activator
)
10,685
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The levels of
urokinase
(
uPA
) and tissue type (tPA) plasminogen activators and their type 1 inhibitor (PAI-1) were determined by immunoassay in tumor cytosols and samples of histologically unaltered adjacent mucosa in gastric cancer patients.
Gastric tumor
revealed enhanced
uPA
and PAI-1 matched by decreased tPA in intact mucosa. The expression of
uPA
and PAI-1 was particularly was high at the later stages of the disease. The concentrations of
uPA
in tumor tissue increased with age. No significant correlation was established between levels of plasminogen activation system components, on the one hand, and histopathological grading of tumor, on the other.
...
PMID:[Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer]. 1278 98
