Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.73 (urokinase-type plasminogen activator)
 10,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this communication we approach the events leading to fertilization in mammals by examining the triangle of egg, sperm and oviductal cell taking account of the local physiology and focussing on auto/paracrine interactions. The expression of growth factors and extra-cellular matrix (ECM)-components in bovine ovarian granulosa- and theca-cells, the oocyte-cumulus complex (OOC) and oviductal epithelium, as well as some of the corresponding secreted proteins can be detected through the estrous cycle. Components of the insulin-like (IGF), fibroblast (FGF) and transforming (TGF) growth factor systems, and also metalloproteinase 1 (MMP1) and urokinase (uPA) are found to be modulated in these cells prior to fertilization. Different expression levels between the cell types are found, each representative of a specific reaction window within that particular stage of the cycle. Our findings support the concept that most of the observed tissue in the reproductive tract is dependent upon on the effects of gonadotropins or steroids, but that the fine-regulation is conveyed by, for example, growth factors and ECM-components. We suggest a sophisticated, auto/paracrine and species-specific crosstalk of growth factors and ECM components between the different cell types involved, enabling fertilization and development of the embryo at the right time and in the right location.
 ...
PMID:Egg-cumulus-oviduct interactions and fertilization. 936 6