Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.7 (plasmin)
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Human Gene/Protein
PLG protein 11.8
plasmin precursor 11.8
LTBP1 protein 11.2
Plasmin 11.2
complement Factor H-related protein 1 10.8
DC33 10.8
Serase-1B 10.8
C9orf46 10.8
alpha 2-plasmin inhibitor 10.7
Tissue factor pathway inhibitor-2 10.4
plasminogen 10.3
insulin-like growth factor type II receptor 10.2
KIAA0709 10.2
tissue factor pathway inhibitor-2 10.2
plasminogen-like 10.1
u-PA 10.0
Plasminogen 10.0
PPY2 9.8
TPSAB1 9.7
PN-I 9.6
centerin 9.5
SERPINB13 9.5
PAI1 mRNA 9.5
SERPINB12 9.5
urokinase-type plasminogen activator 9.4
headpin 9.3
PAI-2 9.3
Urokinase plasminogen activator 9.3
thrombin-activatable fibrinolysis inhibitor 9.3
DC27 9.2
C-type lectin domain family 3 member A 9.2
SPINK9 9.2
SAMP14 9.2
S100A10 protein 9.2
Na+/H+ exchanger isoform NHE-3 9.2
Tissue plasminogen activator 9.1
urokinase plasminogen activator 9.1
tPA 9.0
Carboxypeptidase B 9.0
SK 2 9.0
KREMEN2 9.0
C1 esterase 8.9
plasminogen activator, urokinase 8.9
mannose 6-phosphate/insulin-like growth factor-II receptor 8.9
Neuroserpin 8.8
FDP 8.8
FIP1L1/PDGFRA fusion 8.8
mesotrypsinogen 8.8
gamma hENaC 8.8
neuroserpin 8.8
TFPI-2 8.7
Hageman factor 8.7
S100A10 8.7
CD87 8.7
PLA 8.6
chemokine receptor-like 2 8.6
TMPRSS9 8.6
tissue plasminogen activator 8.6
Apo(a) 8.6
placental protein 5 8.5
MEP1B 8.5
ECRG2 8.5
KLK12 8.5
histidine-rich glycoprotein 8.4
inhibitor-1 8.4
carboxypeptidase N 8.4
tryptase beta I 8.3
SK 1 8.3
annexin A2 8.3
UPA 8.3
plasma prekallikrein 8.3
plasminogen activator inhibitor 8.3
nexin 8.3
plasminogen activator inhibitor-1 8.2
cyclophilin C 8.2
nonmuscle myosin heavy chain IIB 8.2
bomapin 8.2
ADAMTS8 8.2
hurpin 8.2
inter-alpha 8.2
more...
Disease
RP34 11.8
SM-AHNMD 9.4
Idiopathic anaphylaxis 9.0
Cutaneous mastocytosis 9.0
Post-infectious glomerulonephritis 8.8
Ligneous conjunctivitis 8.7
Plasminogen deficiency 8.7
Suppression of ovulation 8.6
Systemic mastocytosis 8.5
XDP 8.4
Telangiectasia macularis eruptiva perstans 8.3
Mastocytosis 8.2
Tripe palms 8.0
mast cell leukemia 7.9
HPC4 7.9
IgG MGUS 7.9
Hepatosplenic schistosomiasis 7.8
Anaphylactoid reaction 7.8
GFD 7.7
Congenital dysfibrinogenemia 7.6
mastocytosis 7.5
Elastolysis 7.4
new onset angina 7.4
Takahara 7.3
urticaria pigmentosa 7.3
Tick-borne relapsing fever 7.2
Eosinophilic bronchitis 7.2
dysfibrinogenemia 7.1
Pleural infection 7.1
vitreous detachment 7.0
Amniotic fluid embolism 6.9
PLAT 6.8
Gestosis 6.7
Amniotic fluid embolism 6.7
Exercise-induced anaphylaxis 6.7
Factor XII deficiency 6.7
hypofibrinogenemia 6.6
Masugi nephritis 6.6
Fletcher trait 6.6
disseminated intravascular coagulation 6.6
Schamberg's disease 6.5
hemorrhagic diathesis 6.5
allergic urticaria 6.5
Surra 6.5
PLG 6.5
cerebral thrombosis 6.4
Hereditary angioedema 6.4
vascular rupture 6.3
Ehrlich Ascites Tumor 6.2
Pancreatic Ductal Adenocarcinoma 6.2
Pancreatic Ductal Adenocarcinoma 6.2
Dengue Shock Syndrome 6.1
chronic eosinophilic leukemia 6.0
platelet disorder 6.0
Pancreatic pseudocyst 5.9
Central retinal vein occlusion 5.9
Congenital hepatic fibrosis 5.9
mastocytoma 5.9
ovarian cancer stage 5.7
Waterhouse-Friderichsen syndrome 5.7
Weber-Christian disease 5.6
Congenital afibrinogenemia 5.6
Crescentic glomerulonephritis 5.6
Systemic amyloidosis 5.6
Pulmonary lymphangioleiomyomatosis 5.5
anaphylaxis 5.5
BMH 5.5
Uncontrolled hypertension 5.5
cerebral degeneration 5.5
Netherton syndrome 5.4
Thrombus 5.4
Thrombophilia 5.4
cerebral hematoma 5.4
postphlebitic syndrome 5.4
Peritoneal fibrosis 5.4
locally advanced cancer 5.4
hypotension and shock 5.4
PIC 5.3
Owren 5.3
bullous dermatoses 5.3
more...
Symptom
Darier's sign 7.8
Cardiovascular symptoms 6.4
localized edema 6.0
Stinging 6.0
Organ failure 5.8
autodigestion 5.8
gumma 5.3
generalized erythema 4.9
periorbital edema 4.8
photopsia 4.7
generalized rash 4.6
Decreased activity 4.3
skin irritant 4.2
Fluctuation 4.1
disturbed balance 4.0
flushing 3.2
orthopnea 2.9
dry skin 2.8
lightheadedness 2.8
eds 2.7
hypoproteinemia 2.6
spasm 2.4
bitter taste 2.3
exertional angina 2.2
skin damage 2.2
chest tightness 2.2
intestinal bleeding 2.1
hepatosplenomegaly 2.0
oliguria 1.9
dysesthesia 1.9
splenomegaly 1.8
acute abdominal pain 1.8
HSA 1.8
rhinorrhea 1.6
functional recovery 1.5
respiratory distress 1.3
collapse 1.1
wheezing 1.1
shortness of breath 1.0
angina 1.0
syncope 0.9
cyanosis 0.9
sneezing 0.9
chest pain 0.9
leg pain 0.8
chills 0.7
skin irritation 0.7
tense 0.7
flank pain 0.7
erythema 0.7
stigma 0.7
thinning 0.6
acute stress 0.6
stridor 0.6
anesthesia 0.6
dizziness 0.5
dry eye 0.4
exhaustion 0.4
paraparesis 0.4
dyspnea 0.3
lethargy 0.3
hypothermia 0.3
bone pain 0.2
low back pain 0.1
epigastric pain 0.0
arthralgia -0.0
memory loss -0.0
vomiting -0.2
hemiplegia -0.2
agitation -0.2
pelvic pain -0.2
nausea -0.4
cough -0.4
abdominal pain -0.6
hyperoxia -0.6
seizures -0.6
Ill -0.7
headache -0.7
hepatomegaly -0.7
paresis -0.7
more...
Drug
Cyclotheonamide A 11.8
Mesoheme 10.5
Warfarin potassium 10.2
Ethyl icosapentate 10.2
Desmoteplase 9.5
Pamiteplase 9.5
Brinase 9.3
uPA 9.2
Urokinase 9.2
Monteplase 9.0
Ancrod 8.8
Anecortave acetate 8.8
Pazopanib hydrochloride 8.8
Streptokinase 8.7
Iotasul 8.6
Activase 8.5
Atomoxetine hydrochloride 8.5
Aquavan 8.5
Ecallantide 8.3
Aprotinin 8.3
Fortimicin 8.1
Methergine 8.1
Batimastat 7.8
Batimastat 7.8
Alteplase 7.8
Valcyte 7.8
Agalsidase alfa 7.8
Alteplase 7.8
Alteplase 7.7
Tranexamic Acid 7.5
Whole human blood 7.5
Nafamostat mesilate 7.4
Batroxobin 7.4
Flolan 7.3
Flolan 7.2
Gabexate mesilate 7.1
Antihemophilic factor 7.1
Antithrombin III 7.1
Hirulog 7.0
Alphagan 6.9
Duloxetine hydrochloride 6.9
Midostaurin 6.8
Sumatriptan succinate 6.8
Insulin glulisine 6.7
Escitalopram oxalate 6.7
Pemetrexed disodium 6.7
Alphagan 6.6
E5564 6.6
DFP 6.5
Ambien 6.5
Ozagrel 6.3
Desmopressin acetate 6.3
Fragment 6.3
Argatroban 6.2
Sulfamylon 6.2
CS-514 6.1
Beraprost 6.0
Genasense 6.0
Ulinastatin 6.0
Tenecteplase 5.9
Myobloc 5.9
Methergin 5.9
CTA 5.9
Radicicol 5.7
Tween 85 5.7
Tiopronin 5.7
Thrombostat 5.7
Orgaran 5.6
PE2 5.6
Ciglitazone 5.5
Golimumab 5.5
Ixabepilone 5.4
lysine 5.3
L-Asparaginase 5.3
Olmesartan medoxomil 5.3
TAT 5.3
Dalteparin 5.3
Pegasys 5.2
Fragmin 5.2
Insulin glargine 5.2
more...
Enzyme
plasmin 11.8
plasminogen activator Pla 10.0
fibrolase 9.9
glutathione-dependent formaldehyde-activating enzyme 9.8
coagulation factor XIa 9.5
urokinase-type plasminogen activator 9.4
C1 esterase 9.3
thrombin-activatable fibrinolysis inhibitor 9.2
proteinase yscD 9.0
tissue plasminogen activator 8.9
endopeptidase I 8.8
Hageman factor 8.7
coagulation factor IXa 8.6
stratum corneum tryptic enzyme 8.6
carboxypeptidase B 8.4
kallikrein 8.3
ancrod 8.2
macrophage elastase 8.1
prostasin 8.0
cathepsin G 7.8
tissue kallikrein 7.7
thrombin 7.6
CPN 7.5
tryptase 7.5
chymosin 7.3
KLK7 7.3
streptopain 7.2
neutrophil elastase 7.2
elastase 7.0
KLK13 7.0
matriptase 6.9
chymotrypsin 6.8
clostripain 6.6
matriptase 6.6
thromboplastin 6.6
Streptomyces griseus protease B 6.6
MMP-3 6.6
stratum corneum chymotryptic enzyme 6.5
cucumisin 6.5
C5a peptidase 6.5
nepenthesin 6.5
trypsin 6.5
neutrophil collagenase 6.5
phosphoamidase 6.5
destabilase 6.5
acrosin 6.5
interstitial collagenase 6.4
Pla 6.4
matrix metalloproteinase 2 6.4
clotting enzyme 6.3
aureolysin 6.2
cathepsin C 6.0
insulin-degrading enzyme 6.0
ScpA 5.9
matrix metalloproteinase 9 5.9
enterokinase 5.8
aggrecanase-1 5.8
collagenase 3 5.8
cathepsin V 5.8
transglutaminase 5.7
endothelin-converting enzyme 5.6
serralysin 5.6
enolase 5.6
APC 5.6
carboxyl proteinase 5.6
cathepsin B 5.5
thermolysin 5.5
papain 5.5
cathepsin D 5.5
neuropsin 5.5
MMP 5.5
sulfhydryl oxidase 5.4
GPI-specific phospholipase C 5.4
heparitinase I 5.4
endoproteinase Glu-C 5.4
collagenase 5.4
lysin 5.3
ficin 5.3
matrix metalloproteinase 14 5.3
TAT 5.3
more...
Compound
tetrahydro-4H-thiopyran-4-one 1,1-dioxide 11.8
Plasmin 11.4
C10H8O2 10.2
6-aminohexanoic acid 9.8
6-aminohexanoic acid 9.8
phenylmethanesulfonic acid 9.8
Adchnon 9.5
3-aminophenylalanine 9.3
Tranexamic acid 8.9
Cetraxate 8.8
Primobolan 8.8
FDP 8.7
Valyl 8.5
diphenyl phosphonate 8.3
FCB 8.2
Fibrinopeptide A 8.2
Norethandrolone 8.1
Fibrin 8.1
Hydroxytamoxifen 8.0
Benzamidine 7.9
Rubomycin 7.7
Diisopropyl fluorophosphate 7.6
Fibrinogen 7.5
isothiocyanatobenzene 7.5
Thrombin 7.2
Oxymetholone 7.2
FC 43 7.1
4000 M 7.1
Mesoridazine 7.1
5-aminoisophthalic acid 7.1
2-naphthalenesulfonic acid 6.9
KIV 6.9
8-quinolinyl 6.9
Chondroitin 6-sulfate 6.9
benzenesulfonyl fluoride 6.9
Galactan 6.7
2-phosphoglycerate 6.7
Azocoll 6.7
Caprolactam 6.7
2,5-piperazinedione 6.6
4-benzylpiperidine 6.6
cyclohexanecarboxylic acid 6.6
cyclohexanecarboxylic acid 6.6
cyclohexanecarboxylic acid 6.6
cyclohexanecarboxylic acid 6.6
cyclohexanecarboxylic acid 6.6
TPCK 6.6
S 10 6.5
Sulfamylon 6.5
PMSF 6.5
aminoacetic acid 6.5
aminoacetic acid 6.5
Z-Gly-Pro 6.5
aminoacetic acid 6.5
aminoacetic acid 6.4
Factor H 6.4
Argatroban 6.3
aminoacetic acid 6.2
Kallikrein 6.2
Homocysteine thiolactone 6.1
Chymostatin 6.0
Trypsin 6.0
Chloral hydrate 6.0
Leupeptin 6.0
P-D 5.9
DIC 5.9
PAR 5.9
Factor X 5.9
Z-Gly 5.8
Casein 5.8
hexanoic acid 5.8
A 150 5.7
Dianabol 5.7
Benazepril 5.7
hexanoic acid 5.7
M 3 5.6
Leupeptin 5.6
Collagenase 5.6
4-phenylpiperidine 5.5
lysine 5.4
more...