Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.7 (plasmin)
 9,023 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
plasminogen 3554
urokinase-type plasminogen activator 1898
PLA 1891
thrombin 1860
fibrinogen 1514
tissue plasminogen activator 693
Plasmin 646
Sep 616
Plasminogen 549
plasminogen activator inhibitor-1 540
serine protease 507
antithrombin III 379
collagen 365
plasminogen activator inhibitor 365
kallikrein 364
prothrombin 348
SDS 309
chymotrypsin 305
fibronectin 278
Mol 277
antithrombin 269
casein 220
factor Xa 220
glycoprotein 207
matrix metalloproteinase 201
alpha 2-plasmin inhibitor 200
uPAR 193
trypsin inhibitor 186
tPA 184
urokinase plasminogen activator 179
thromboplastin 165
collagenase 163
polypeptide 155
u-PA 154
tissue factor 144
thrombomodulin 142
serine protease inhibitor 134
bradykinin 134
protein C 133
mast cell 122
MMP-9 119
von Willebrand factor 116
albumin 114
FDP 112
cathepsin G 111
MMP-2 111
cytokine 108
vitronectin 108
inhibitor-1 106
Lp(a) 101
protease inhibitor 100
PAI-2 84
insulin 84
neutrophil elastase 83
HNE 83
PAI 80
TGF-beta 80
metalloproteinase 79
annexin II 76
ADP 74
Tissue plasminogen activator 73
thrombin-activatable fibrinolysis inhibitor 73
factor XII 65
tumor necrosis factor 65
MMP-1 64
nexin 63
esterase 62
matrix metalloproteinase 2 62
vascular endothelial growth factor 62
lipopolysaccharide 61
C1 inhibitor 61
serum albumin 61
MMP-3 61
transforming growth factor-beta 60
thrombin inhibitor 60
Trypsin 60
urinary kallikrein 60
VIII 59
carboxypeptidase B 58
alpha 1-antitrypsin 58
epidermal growth factor 58
alpha2-macroglobulin 56
factor VIII 55
stromelysin 54
Hageman factor 53
cathepsin D 53
transglutaminase 53
Met 53
cathepsin B 53
protein S 53
heavy chain 53
beta-thromboglobulin 52
thrombospondin 52
beta 1 52
enolase 51
factor XIIIa 51
IgE 50
KIT 49
factor VII 49
renin 49
alpha-chain 47
serine proteinase inhibitor 46
MMP 46
DIC 44
fused 43
annexin A2 43
EPA 43
elastin 42
PAR 42
metalloprotease 41
gamma chain 41
platelet factor 4 40
amyloid precursor protein 39
dimeric 38
hepatocyte growth factor 38
tissue factor pathway inhibitor 38
proteoglycan 38
hemoglobin 37
cell surface receptor 36
S100A10 36
vascular endothelium 36
Pol 36
membrane-bound 35
plasma prekallikrein 35
LPS 35
TNF-alpha 35
tissue inhibitor of metalloproteinases 35
C-reactive protein 33
insulin-like growth factor 33
IGF-I 33
type I collagen 33
Pseudomonas 33
CD87 32
interleukin-6 32
factor XI 31
factor V 31
PAP 31
beta-casein 31
PCI 31
TNF 30
IL-6 30
VEGF 30
tyrosine kinase 29
alpha-enolase 29
TIMP-2 29
hyaluronidase 29
ENaC 29
THP 29
angiotensin II 29
fur 29
CPU 28
TAT 27
glycolytic enzyme 27
inter-alpha-trypsin inhibitor 27
alkaline phosphatase 26
ERK1 26
TPA 26
cysteine protease 26
histidine-rich glycoprotein 26
neuroserpin 25
more...
Disease
cancer 539
tumor 510
SDS 309
disseminated intravascular coagulation 232
stroke 162
atherosclerosis 148
acute myocardial infarction 126
mastocytosis 115
myocardial infarction 111
diabetes 110
anaphylaxis 104
Alzheimer's disease 99
sepsis 97
melanoma 94
metastases 94
deep vein thrombosis 93
carcinoma 92
tumor growth 91
sepsis 86
breast cancer 84
tumor progression 78
coagulopathy 65
pulmonary embolism 64
cardiovascular disease 62
hypertension 61
plaque 61
ischemia 55
leukemia 54
glomerulonephritis 51
proteinuria 50
rheumatoid arthritis 49
asthma 49
acute promyelocytic leukemia 43
hepatocellular carcinoma 43
coronary artery disease 43
fibrosarcoma 41
renal disease 37
mastitis 36
nephrotic syndrome 36
nephritis 35
cirrhosis 35
depression 34
arthritis 34
vascular disease 34
lung cancer 32
uterus 32
Hereditary angioedema 32
glioma 31
Yersinia 31
infectious diseases 30
thrombocytopenia 30
mastocytoma 29
squamous cell carcinoma 29
systemic lupus erythematosus 28
ovarian cancer 28
diabetic nephropathy 28
prostate cancer 27
Thrombus 27
cornea 26
Mastocytosis 26
Systemic mastocytosis 25
obesity 24
adenocarcinoma 24
glomerulosclerosis 23
urticaria 23
lung carcinoma 23
mole 23
influenza 23
cold 22
tumorigenesis 22
preeclampsia 22
myocardial ischemia 22
leptospirosis 22
multiple myeloma 22
mole 22
type 2 diabetes 21
cerebral ischemia 21
osteoarthritis 21
Lyme disease 21
MCF 20
renal failure 20
lymphoma 20
pemphigoid 19
SEM 19
osteoporosis 19
acute myeloid leukemia 19
antiphospholipid syndrome 19
pemphigus 19
periodontitis 18
Rous sarcoma 18
tumor angiogenesis 18
pertussis 18
haemophilia 18
psoriasis 18
glioblastoma 18
hemorrhagic diathesis 17
Blocking 17
diabetic retinopathy 17
multiple sclerosis 17
arteriosclerosis 17
neuroblastoma 17
primary tumor 17
thrombocytopenic purpura 17
urticaria pigmentosa 16
liver disease 16
chronic renal failure 16
plague 16
colon cancer 16
pneumonia 16
subarachnoid hemorrhage 16
unstable angina 16
carcinogenesis 15
anemia 15
coronary heart disease 15
cerebral infarction 15
von Willebrand disease 15
vitreous detachment 15
hypofibrinogenemia 15
epithelial ovarian cancer 15
PLG 15
Haemophilia 14
peritonitis 14
pulmonary fibrosis 14
sarcoma 14
vasculitis 14
pruritus 14
acute pancreatitis 14
lupus 13
abdominal aortic aneurysm 13
coronary thrombosis 13
heart failure 13
gastric cancer 13
HIV 13
Infection 12
pancreatic cancer 12
PIC 12
lupus 12
XDP 12
choriocarcinoma 12
hyperglycemia 12
meningitis 12
aortic aneurysm 12
suicide 12
Mycoplasma 12
eosinophilia 12
bacterial infection 12
mast cell leukemia 12
endocarditis 11
osteosarcoma 11
worms 11
rash 11
skin disease 11
rare disease 11
bronchospasm 11
PAM 11
pancreatitis 11
myeloproliferative disorders 11
dysfibrinogenemia 10
GSH 10
acute leukemia 10
more...
Symptom
anesthesia 46
pain 26
collapse 18
flushing 17
seizures 15
respiratory distress 14
angina 12
spasm 11
functional recovery 11
splenomegaly 10
dyspnea 10
headache 10
diarrhea 9
chest pain 9
vomiting 8
erythema 6
abdominal pain 6
hypothermia 6
stigma 6
cough 5
autodigestion 5
exhaustion 5
syncope 5
hepatosplenomegaly 5
nausea 5
thinning 5
dizziness 4
starvation 4
analgesia 4
Decreased activity 3
low back pain 3
shortness of breath 3
Darier's sign 3
wheezing 3
discomfort 3
Fluctuation 3
discomfort 3
HSA 3
agitation 3
oliguria 2
Welt 2
eds 2
acute abdominal pain 2
cyanosis 2
skin damage 2
lethargy 2
acute stress 2
localized edema 2
dry skin 2
acidity 2
rhinorrhea 2
arthralgia 2
fatigue 2
chills 2
Ill 2
bitter taste 2
hypoproteinemia 2
periorbital edema 2
tremor 1
photopsia 1
chest tightness 1
intestinal bleeding 1
bone pain 1
hyperoxia 1
disturbed balance 1
dry eye 1
leg pain 1
Stinging 1
hemiplegia 1
generalized rash 1
sleepiness 1
vertigo 1
regurgitation 1
tense 1
hemoptysis 1
paresis 1
pelvic pain 1
memory loss 1
skin irritant 1
stridor 1
skin irritation 1
flank pain 1
gumma 1
sneezing 1
dysesthesia 1
exertional angina 1
hepatomegaly 1
generalized erythema 1
lightheadedness 1
Cardiovascular symptoms 1
orthopnea 1
ataxia 1
Organ failure 1
epigastric pain 1
back pain 1
nausea and vomiting 1
paraparesis 1
Drug
lysine 678
uPA 358
Urokinase 101
Dermatol 101
Aprotinin 81
Cardiovasc 72
Streptokinase 65
Asn 58
Fragment 51
Gel 37
TAT 27
DFP 24
CTA 24
lactose 21
Antithrombin III 20
Asthma 18
Alteplase 16
CaCl2 16
CaCl2 16
CaCl2 16
Alteplase 16
Alteplase 14
Ancrod 13
ABC 12
Gelatin 11
Nephron 10
Nephron 10
MAP 9
DDAVP 9
PTC 9
DDAVP 9
ascorbate 8
Amiloride 8
Amiloride 8
IFN-gamma 8
Albumin 7
ACT 7
CSF 7
Bifidobacterium 6
AMC 6
Batimastat 6
Batimastat 6
L-tyrosine 6
Pronase 6
Monit 5
Dial 5
ROS 5
Argatroban 5
Captopril 5
Activase 5
AHF 4
balanced salt solution 4
Angiotensin II 4
Bayer 4
Fraction 4
PTH 4
Lovastatin 4
Fluorescein 4
ampicillin 4
vitamin E 4
Dalteparin 4
Batroxobin 3
EPA 3
EE2 3
Doxycycline 3
Hypaque 3
Gabexate mesilate 3
Nafamostat mesilate 3
Retinoic acid 3
Guanidine 3
PE2 3
EPI 3
MRC 3
CPR 3
Guanidine 3
Vitamin B12 3
Vitamin E 3
Indomethacin 3
Hypaque 3
Fluorescein 3
Ecallantide 2
PFA 2
citric acid 2
Methylprednisolone 2
Fragmin 2
ENT 2
Midostaurin 2
CIA 2
DNase I 2
VCR 2
Desmoteplase 2
TAK 2
Brinase 2
Bestatin 2
Biopolymers 2
nitroglycerin 2
BLM 2
ARA-C 2
Alanine 2
Hyaluronidase 2
Histamine 2
Hirulog 2
ROC 2
BoNT/A 2
Prednisolone 2
Spectrum 2
Ulinastatin 2
Adriamycin 2
Imatinib 2
Ringer's solution 2
Ethanol 2
Hyaluronidase 2
L-Asparaginase 2
GEO 2
Mesoheme 2
Glutathione 2
Genasense 1
Apixaban 1
Flolan 1
Gleevec 1
Ketorolac 1
LMWH 1
Ketotifen 1
Rocuronium 1
Valcyte 1
TAC 1
Cibacron Blue 1
Beraprost 1
Tranexamic Acid 1
CCL 1
Gefitinib 1
Campath 1
Zoledronic acid 1
Denosumab 1
Pepstatin 1
Phosphatidylserine 1
Whole human blood 1
Glutamic acid 1
Allergen 1
Alphagan 1
Tween 85 1
Tannic acid 1
Indocyanine green 1
-deoxyadenosine 1
Golimumab 1
Antihemophilic factor 1
CTX 1
Gelfoam 1
Methergine 1
NAG 1
Zoledronic acid 1
Portal 1
NaI 1
NADH 1
Methergin 1
RSM 1
MgSO4 1
Thrombostat 1
Activin 1
DMAP 1
more...
Enzyme
plasmin 9023
urokinase-type plasminogen activator 2013
thrombin 1812
tissue plasminogen activator 1564
trypsin 1106
kallikrein 534
thromboplastin 370
chymotrypsin 351
elastase 341
APC 218
collagenase 214
neutrophil elastase 165
tryptase 138
cathepsin G 116
MMP-3 93
papain 83
ERK 78
tissue kallikrein 76
transglutaminase 71
Hageman factor 61
carboxypeptidase B 59
mitogen-activated protein kinase 57
matrix metalloproteinase 2 54
pepsin 54
MMP 53
cathepsin B 53
cathepsin D 52
enolase 51
protein kinase C 51
renin 49
thrombin-activatable fibrinolysis inhibitor 43
protein kinase 40
subtilisin 40
hyaluronidase 40
matrix metalloproteinase 9 37
peroxidase 37
CD10 32
hyaluronidase 29
furin 29
glyceraldehyde-3-phosphate dehydrogenase 28
phospholipase C 28
glyceraldehyde-3-phosphate dehydrogenase 27
TAT 27
alkaline phosphatase 26
glyceraldehyde-3-phosphate dehydrogenase 25
glyceraldehyde-3-phosphate dehydrogenase 25
glyceraldehyde-3-phosphate dehydrogenase 25
thermolysin 24
interstitial collagenase 23
focal adhesion kinase 23
CPN 23
neuraminidase 23
deaminase 22
Pla 22
chymosin 21
chondroitinase 19
lipase 19
ancrod 19
catalase 19
ACE 19
DNase 19
reverse transcriptase 17
phospholipase A2 17
acrosin 17
chondroitinase 17
matriptase 14
proteinase K 14
matriptase 13
beta-galactosidase 13
insulin-degrading enzyme 13
MEK 13
lysozyme 12
luciferase 12
lactate dehydrogenase 12
C1 esterase 12
chymase 12
fibrolase 12
lysin 12
acid phosphatase 11
prostasin 11
enterokinase 11
caspase-3 11
apyrase 11
heparinase 11
macrophage elastase 11
PAM 11
PTA 10
phosphoglycerate kinase 9
creatine kinase 9
ceruloplasmin 9
endothelin-converting enzyme 9
C3 convertase 9
adenylate cyclase 8
prostate-specific antigen 8
glutathione S-transferase 8
KLK7 8
ATPase 8
coagulation factor XIa 8
cathepsin L 8
C3 convertase 8
superoxide dismutase 8
beta-glucuronidase 8
carboxypeptidase A 7
clostripain 7
cathepsin C 7
xanthine oxidase 7
deoxyribonuclease 7
cathepsin K 7
deoxyribonuclease 7
leucine aminopeptidase 7
alanine aminotransferase 7
lipoxygenase 7
proteasome 7
acetylcholinesterase 7
TSP-1 6
RNA polymerase 6
MAP 6
GAS 6
gamma-glutamyl transpeptidase 6
RNase 6
carboxylesterase 6
RNase 6
neutrophil collagenase 5
granzyme B 5
phosphodiesterase 5
lipoprotein lipase 5
endoproteinase Glu-C 5
CD13 5
bromelain 5
dipeptidyl peptidase IV 5
type III procollagen 5
NADPH oxidase 5
lysyl endopeptidase 5
aspartate aminotransferase 5
aldolase 4
PNGase F 4
calcineurin 4
clotting enzyme 4
PGM 4
meprin 4
ficin 4
prolyl endopeptidase 4
transcriptase 4
AMPK 4
PARP 4
cathepsin H 4
E-2 4
factor D 4
ACS 4
ScpA 3
chloramphenicol acetyltransferase 3
arginase 3
pyruvate kinase 3
SpeB 3
factor C 3
micrococcal nuclease 3
SPC 3
cruzipain 3
sialyltransferase 3
sialyltransferase 3
more...
Compound
lysine 956
serine 724
Dec 647
Plasmin 619
Clin 539
arginine 503
SDS 324
sulfate 308
sodium 307
calcium 273
DNA 195
Thrombin 182
Fibrin 167
leucine 166
Phe 162
alanine 155
NH2 152
Gly 142
Fibrinogen 136
cysteine 133
ACS 116
EDTA 114
FDP 112
acetate 110
EDTA 106
ADP 103
tyrosine 102
His 98
Asp 91
methionine 84
glucose 81
urea 80
oxygen 79
ADP 74
ADP 74
6-aminohexanoic acid 71
phosphate 71
6-aminohexanoic acid 71
Heparin 68
Ile 67
DEAE 66
threonine 65
water 63
zinc 61
glutamic acid 60
Trypsin 60
Tranexamic acid 59
salt 57
ammonium 54
PEG 50
Cardiol 45
bromide 44
DIC 44
creatinine 43
PAR 42
retinoic acid 42
ASA 41
PEG 38
MDA 38
galactose 38
PMSF 37
proline 34
Serine 32
PAP 31
PAP 31
PAP 31
PAP 31
Triton X-100 31
nitrogen 31
ethanol 30
TNF 30
TEM 29
nitric oxide 29
THP 29
THP 29
HCl 29
copper 28
hydrogen 28
Casein 28
Collagen 28
acrylamide 28
glutamine 25
cAMP 25
acetic acid 24
thioglycollate 23
iron 23
acetone 23
prostacyclin 23
tryptophan 22
hyaluronic acid 22
tryptophan 22
tryptophan 22
tryptophan 22
iodine 21
aldosterone 21
PAM 21
Tris 21
PAM 21
AMP 21
homocysteine 20
glycerol 19
guanidine 19
aminomethyl 18
valine 18
TPA 18
chloroform 18
TPA 18
Insulin 17
TCA 17
glutamate 16
ATP 16
potassium 16
CaCl2 16
prostaglandin E1 16
PMA 16
Tris 15
palmitic acid 15
asparagine 14
Factor H 14
Kallikrein 14
Collagenase 14
PMA 14
aspartic acid 13
TOF 13
Mg2+ 13
H2O2 13
PAM 12
cyclohexane 12
aspartic acid 12
aspartic acid 12
SCC 12
aspartic acid 12
methylhistamine 11
GSH 11
ATF 11
GSH 11
nickel 11
Fibrinopeptide A 11
hexanoic acid 11
hexanoic acid 11
CO2 11
Dexamethasone 11
MEK 10
retinol 10
NMDA 10
aldehyde 10
methanol 10
TPCK 10
aldehyde 10
2-phosphoglycerate 9
hydroxylamine 9
PGE2 9
hydroxylamine 9
Cereb 9
COS 9
phenol 9
Ang II 9
Optimal 8
Dextran 8
2-mercaptoethanol 8
more...