Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.7 (plasmin)
 9,023 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activity of milk plasmin, plasminogen and N-acetyl-beta-glucosaminidase (NAGase) and the trypsin-inhibitor capacity (TIC) were monitored in 40 quarters during the first month of lactation. TIC and NAGase activity decreased rapidly and plasmin activity more slowly during the first week. Conversely milk plasminogen increased as time elapsed from parturition. When the quality of whey was analysed as a growth medium for mastitis pathogens, a slight inhibition in the growth of Escherichia coli, Staphylococcus aureus and Streptococcus agalactiae was seen at the day of parturition. There was a distinct stimulatory effect on the growth of Str. agalactiae during the second week of lactation. No relationship was found between in vitro bacterial growth and respective plasmin or plasminogen activity in milk.
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PMID:Changes in milk plasminogen, plasmin and in vitro bacterial growth in whey during early lactation. 253 63

An experimental model of crescentic type nephritis was established by immunizing rats that had been given at i.v. nephritogenic dose (0.4 ml/animal) of rabbit anti-rat glomerular basement membrane (GBM) serum [anti-GBM serum] with 5 mg of rabbit gamma-globulin in Freund's complete adjuvant, and the process of nephritis was investigated by means of biochemical, histopathological and immunopathological analyses. Rats treated with anti-GBM serum and then with rabbit gamma-globulin (group II) showed significantly high levels or a tendency for high levels of urinary protein content, N-acetyl-beta-glucosaminidase activity and plasmin-like activity from the 20th day to the 40th day observations after the induction of nephritis, when compared to rats given anti-GBM serum alone (group I). On the 40th day, plasma urea nitrogen, cholesterol and fibrinogen levels were significantly higher in group II than in group I. Glomerular histopathological examination on the 40th day revealed that the incidence and the degree of severity of crescent formation, adhesion of capillary walls to Bowman's capsule and fibrinoid degeneration were remarkably greater in group II than in group I. However, no significant difference was seen between both groups on the thickening of capillary walls and mesangial proliferation. Linear deposits of rabbit IgG and rat IgG along the capillary walls as well as fibrinogen-reactive material deposits in Bowman's capsular spaces were observed by the immunofluorescence technique in both groups. The deposition of fibrinogen-reactive materials was considerably greater in group II than in group I. Moreover, the deposition of rat IgG was slightly greater in group II. These results suggest that the nephritis of group II closely resembles rapidly progessive glomerulonephritis in humans and thus seems to be an adequate experimental model for screening beneficial drugs on this type of nephritis.
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PMID:Crescentic type nephritis induced by anti-glomerular basement membrane (GBM) serum in rats. 666 63

Using a modified model of Masugi's nephritis of rats, various enzymatic activities in urine, serum and renal tissue (glomeruli or cortex) were determined at appropriate intervals after the administration of anti-kidney serum and compared with the urinary protein content and the kidney weight. In the urine, alkaline phosphatase (Al-Phosase), acid phosphatase (Ac-Phosase) and N-acetyl-beta-glucosaminidase (NA-beta-Gase) activities remarkably increased after the induction of nephritis, reached their peaks on the 10th day and reverted to almost the normal levels on the 30th day. The patterns of time course of these enzymatic activities were similar to patterns seen in the urinary protein content and the kidney weight. In the serum, the Al-Phosase activity decreased slightly, while NA-beta-Gase activity increased slightly. The Ac-Phosase activity in serum remained at normal levels during the experimental periods. In the glomeruli, the bound activities of these three enzymes decreased with nephritis, showing a negative correlation with results in the urine. On the other hand, fibrinolytic activities in the urine (plasmin-like enzyme) and renal cortex (plasminogen activator) also paralleled the urinary protein content and the kidney weight in the course of the disease. These results suggest that the Al-Phosase, Ac-Phosase and NA-beta-Gase excreted into urine in cases of nephritis may be mostly derived from damaged renal cells and one part of Al-Phosase may also come from the plasma. Moreover, the increase of plasmin-like enzyme in urine is considered to be due to the increase of plasminogen activator in the renal cortex. Thus, the determination of these enzymatic activities in the urine should be useful for evaluating effects of drugs for the treatment of nephritis.
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PMID:Pharmacological studies on experimental nephritic rats (9). Changes in activities of urinary enzymes in the modified type of Masugi's nephritis and their sources. 720 60