Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.7 (
plasmin
)
9,023
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pregnancy zone protein
(PZP, alpha 2-PAG, SP3) was found to bind to
plasmin
in crossed affino-immunoelectrophoresis using sodium caseinate in the first dimension gel. The
plasmin
presence in the PZP-
plasmin
complex was confirmed by addition of antiserum against plasminogen to the gel. In crossed affino-immunoelectrophoresis using
plasmin
in the first dimension gel a non migrative PZP immunoreactive peak appeared, similar to the peak obtained with casein in the first dimension gel. Incubation of mixtures of PZP and
plasmin
also demonstrated complex formation between PZP and
plasmin
. The complex between PZP and
plasmin
could be precipitated not only by anti-PZP antibodies, but also by anti-plasminogen antibodies, confirming the interaction between the two molecules. The significance of the binding between
plasmin
and PZP remains to be elucidated, but it is tempting to speculate that PZP, present on the trophoblastic surface, immobilizes
plasmin
, rendering this molecule able to perform a local fibrinolytic activity.
...
PMID:Interaction between pregnancy zone protein and plasmin. 297 40
