Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.7 (
plasmin
)
9,023
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Injection of ACTH or cortisone has no effect on the amount of
fibrinolysin
resulting from the activation of profibrinolysin by peptone. Antifibrinolytic activity of serum is significantly increased by ACTH or cortisone but not by desoxycorticosterone or corticosterone. No increase in anti-fibrinolytic power of serum is produced, however, by the injection of ACTH or cortisone in splenectomized guinea pigs.
Splenin
A has the same action on
fibrinolysin
inactivation as ACTH or cortisone.
Splenin
B has the opposite effect. This action on the antifibrinolytic power of serum appears to be due to an acceleration of the rate of combination between the enzyme and its inhibitor and not to an actual increase in antifibrinolysin. The possible significance of these observations is discussed.
...
PMID:Studies on the fibrinolysin-antifibrinolysin system in serum. I. Action of the anterior pituitary, adrenal cortex, and spleen. 1480 33
