Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.7 (plasmin)
 9,023 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acetyl-salicylic acid has been found to inhibit the aggregation of erythrocytes and thrombocytes stimulated by proteolytic enzymes (fibrinolysin and trypsin) and phospholipase A. It hampers their hydrolytic action on phospholipids of the blood cells membranes, prevents deformation of the latter under the effect of aggregating agents and also averts a fall of the ATP-ase activity of the erythrocytes membranes caused by parachlormercury-benzoate.
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PMID:[Mechanism of the action of acetylsalicyclic acid on formed element aggregation]. 14 11

With the aim of prophylaxis of early postoperative thrombosis in reparative operations on veins of the lower extremities acetyl salicylic acid (aspirin) was used. Diminishing of adhesion and aggregation of thrombocytes, a reduced fibrinase activity and lessening of clot density were noted.
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PMID:[Role of drugs with disaggregative effect in the prevention of thrombosis in reconstructive operations on the veins of the limbs]. 99 51

Right heart assist (RHA) was used for coronary artery bypass grafting (CABG). We explored the affection of the coagulation system during surgery and evaluated two different antithrombotic treatments postoperatively. The pilot study comprised 14 patients. During surgery activated clotting time (ACT) was kept > 200 sec. By random the patients were selected to different postoperative treatments. The control group received acetyl salicylic acid (ASA) 150 mg daily, the intervention group received ASA 150 mg daily and Low Molecular Weight Heparin (LMWH) 5000 IU x2 for three days. Serum levels of prothrombin fragment 1 and 2 (F 1 + 2), plasmin-antiplasmin product (PAP), anti-Xa activity and functional antithrombin (ATIII) were measured. During surgery there was no increase of F 1 + 2 or PAP. After protamin was administered there was a significant increase of F 1 + 2 but not in PAP during the next 6 hours. Postoperative antithrombotic treatment with LMWH seems to normalise F1 + 2 while ASA does not. ACT level > 200 sec. seems sufficient for RHA-CABG surgery. Fibrinolytic agents are not necessary. It seems that postoperative LMWH treatment prevents increased thrombin formation. General recommendations with respect to antithrombotic treatment beyond ASA can not be made based on study.
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PMID:Postoperative treatment with low molecular weight heparin after right heart assist for coronary artery bypass grafting. 1626 1