Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.69 (APC)
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Human Gene/Protein
GCST 10.9
APC 10.9
CENTG3 10.9
USP37 protein 10.9
LONRF2 10.9
ZNF584 10.9
ZBTB22 10.9
Protein C 10.9
CORT protein 10.9
ZNF430 10.9
protein C 10.9
trigger of mitotic entry 1 10.9
APC7 10.7
type I protein C 10.6
APC8 10.6
anaphase-promoting complex/cyclosome 10.6
plasma protein C 10.6
APC3 10.4
endothelial protein C receptor 10.3
tumor suppressor APC 10.2
APC4 10.2
protein S 10.0
KEN 10.0
KIAA1731 9.9
CCDC15 9.9
MFSD9 9.9
ZNF767 9.9
HCC5 9.9
G8 protein 9.9
early mitotic inhibitor 1 9.9
Protein tyrosine phosphatase, receptor type, C 9.9
UBE2V 9.9
IL-12R-beta2 9.9
AURKAIP1 9.9
H4F2 9.9
B-cell CLL/lymphoma 9 protein 9.9
MYH mRNA 9.9
ZNF688 9.9
TPARL 9.9
Serase-1B 9.9
PRGP1 9.9
ANKRD45 9.9
ABTB2 9.9
MAD2L1 binding protein 9.9
CCDC84 9.9
VHL-like protein 9.9
APC5 9.9
Thrombomodulin 9.8
APC10 9.8
EMI2 9.8
FZR1 9.7
Protein S 9.7
UBE2S 9.7
SWM1 9.7
mixed lineage kinase 4 9.6
CYP27C1 9.6
APC11 9.6
factor V Leiden 9.5
EPCR 9.5
EMI1 9.5
APC protein 9.4
factor V 9.4
ZSWIM7 9.3
TBC1D12 9.3
Copine III 9.3
LRP9 9.3
oculomedin 9.3
RBM44 9.3
PRR15 9.3
HIAT1 9.3
MAGEB18 9.3
CNBD1 9.3
ATP8B4 9.3
cytochrome b5 reductase-like 9.3
THROMBOSPONDIN 9.3
KIAA0696 9.3
PPP2R3 9.3
C11orf65 9.3
thrombomodulin 9.3
APC1 9.3
more...
Disease
Acquired hypoprothrombinemia 10.9
MLVI2 10.9
Omental gangrene 10.9
APC 10.6
hereditary protein C deficiency 10.6
Protein C deficiency 10.6
Activated protein C resistance 10.5
PC deficiency 10.5
Sepsis with acute organ dysfunction 10.3
HPC4 10.2
Duodenal polyposis 9.9
Factor II mutation 9.9
Duodenal mass 9.9
Noninfective endocarditis 9.9
Acute coagulopathy 9.7
Antithrombin deficiency 9.6
Factor V Leiden mutation 9.5
MYH-associated polyposis 9.5
Coumarin necrosis 9.3
Protein S deficiency 9.2
Purpura fulminans 9.1
Disorders of mitochondrial metabolism 8.9
VKCFD1 8.9
Serrated adenoma 8.8
AAPC 8.7
Familial Hypertrophic Cardiomyopathy 8.6
Aberrant Crypt Foci 8.6
goiter with hyperthyroidism 8.6
epituberculosis 8.6
Thrombophilia 8.6
Severe sepsis 8.5
von Willebrand disease type 2N 8.3
Adenocarcinoma of the gastroesophageal junction 8.3
Hypodysfibrinogenemia 8.3
Neonatal thrombocytopenia 8.2
Turcot syndrome 8.1
familial adenomatous polyposis 8.1
fulminant purpura 8.1
von Willebrand disease type 2N 8.1
MHS6 8.1
Carotid artery thrombosis 8.1
dysfibrinogenemia 8.1
Duodenal cancer 7.9
clotting factor deficiency 7.9
Placental infarction 7.8
Bacteroides bacteremia 7.8
Periampullary carcinoma 7.8
Gastric adenoma 7.8
Corpus uteri 7.8
circulating anticoagulants 7.7
bee sting allergy 7.5
Carbohydrate-deficient glycoprotein syndrome 7.4
Heparin-induced thrombocytopenia with thrombosis 7.3
mesenteric thrombosis 7.3
HNPCC 7.2
KAL2 7.2
Abdominal sepsis 7.2
Livedoid vasculitis 7.2
Superior mesenteric vein thrombosis 7.2
Thyroid Carcinoma 7.1
Mink enteritis 7.1
Lipodermatosclerosis 7.1
homocystinemia 7.1
Mayaro fever 7.0
Free plasma hemoglobin 6.9
Gastric polyps 6.9
Cerebral venous thrombosis 6.9
superficial thrombophlebitis 6.8
Recurrent pulmonary embolism 6.8
Plasminogen deficiency 6.8
Factor XII deficiency 6.8
Vaccinia virus infection 6.8
AIMAH 6.8
Gardner's syndrome 6.8
polyposis 6.8
desmoid 6.7
HRPT2 6.7
Phlegmasia cerulea dolens 6.6
Portal vein thrombosis 6.6
Trousseau's syndrome 6.6
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Symptom
Unexplained abdominal pain 7.8
Livedoid 7.3
Intermittent fever 7.2
Organ failure 5.0
livedo 4.9
leg edema 4.1
anal pain 4.0
left upper quadrant pain 3.9
Flare 3.5
peri-menopausal 3.4
Neurologic symptoms 3.4
impaired motor coordination 3.3
pedal edema 3.2
hyperemesis 2.7
Fluctuation 2.7
right lower quadrant pain 2.7
respiratory distress 2.6
right upper quadrant pain 2.5
eye pain 2.4
mastalgia 2.3
intestinal bleeding 2.3
Spots 2.1
DNA marker 2.1
HSA 2.0
hemiplegia 2.0
syncopal episodes 1.9
tachypnea 1.9
clumsiness 1.8
hypoproteinemia 1.8
neuralgia 1.7
presyncope 1.7
neck stiffness 1.7
dysarthria 1.6
splenomegaly 1.6
leg pain 1.5
epigastric pain 1.5
abdominal pain 1.5
chills 1.5
erythema 1.4
exertional angina 1.4
hypothermia 1.4
chest tightness 1.3
colic 1.3
hypotonia 1.2
pallor 1.2
shortness of breath 1.2
hyperoxia 1.2
chest pain 1.1
dysesthesia 1.0
functional recovery 1.0
hepatomegaly 1.0
paresis 1.0
exhaustion 1.0
acute abdominal pain 1.0
acute abdomen 0.9
chorea 0.9
emaciation 0.9
hot flashes 0.9
hepatosplenomegaly 0.8
angina 0.8
abnormal gait 0.8
starvation 0.8
lethargy 0.8
decreased appetite 0.7
facial pain 0.7
muscle stiffness 0.7
cyanosis 0.6
fasciculation 0.6
tonic-clonic seizure 0.6
asthenia 0.6
dyspnea 0.5
collapse 0.4
hemoptysis 0.3
headache 0.3
photophobia 0.3
torticollis 0.3
bloating 0.2
vomiting 0.2
exertional dyspnea 0.2
abdominal discomfort 0.2
more...
Drug
Edodekin alfa 10.9
Selodenoson 10.9
Efaproxiral sodium 10.9
Drotrecogin alfa 10.1
Drotrecogin alfa 10.1
Zofenopril calcium 9.1
Motexafin lutetium 8.6
Holin 8.6
APD-356 8.1
Antithrombin III 8.1
Percodan 7.9
Gemifloxacin mesylate 7.8
Zanolimumab 7.6
Desmoteplase 7.6
Parecoxib sodium 7.5
Ximelagatran 7.4
Fosamprenavir calcium 7.2
Z-Pro-Prolinal 7.2
Valdecoxib 7.0
Kifunensine 6.9
Percocet 6.9
Zomepirac sodium 6.9
Valcyte 6.9
OP-2 6.8
Hemolink 6.8
Bextra 6.8
Provenge 6.7
Warfarin sodium 6.6
Ziprasidone hydrochloride 6.5
PT-141 6.5
Ecallantide 6.5
Mononine 6.3
Ancrod 6.3
Antihemophilic factor 6.2
L-Asparaginase 6.1
Betamethasone dipropionate 6.1
Phenprocoumon 6.0
Dextran sulfate sodium 5.9
Coumadin 5.8
Palonosetron hydrochloride 5.8
Orgaran 5.8
Vitamin K 5.7
Cangrelor 5.6
PTC 5.5
Nesiritide 5.5
fluphenazine dihydrochloride 5.5
Eszopiclone 5.4
Clemastine 5.4
Vioxx 5.4
Fragmin 5.4
Sivelestat 5.3
Irinotecan 5.3
CS-514 5.3
Beraprost 5.2
Frovatriptan 5.1
Genasense 5.1
Intron A 5.1
Efalizumab 5.1
Chloramine T 5.1
Efalizumab 5.1
Kaolin 5.0
Batroxobin 5.0
Nafamostat mesilate 5.0
Fondaparinux 4.9
Intron A 4.9
Abatacept 4.9
Intron A 4.9
IFN-gamma 4.8
Pimobendan 4.8
Levitra 4.8
IL-2 4.7
Argatroban 4.7
Rasagiline 4.6
Copaxone 4.6
CPT-11 4.6
Calcipotriol 4.6
Lipitor 4.6
Vitamin B12 4.6
TAT 4.6
Darbepoetin alfa 4.6
more...
Enzyme
APC 10.9
choline-sulfatase 10.9
sarcosine reductase 9.3
EC 5.4.99.15 8.6
thrombin-activatable fibrinolysis inhibitor 8.1
separase 7.9
duodenase 7.9
glycine reductase 7.9
succinyl-diaminopimelate desuccinylase 7.6
STK11 7.6
RVV-V 7.2
histidinol phosphate aminotransferase 7.0
thromboplastin 6.9
thrombin 6.9
phycocyanobilin:ferredoxin oxidoreductase 6.8
bacillolysin 6.6
vibriolysin 6.5
aminopeptidase Y 6.5
dichloromethane dehalogenase 6.5
C1 esterase 6.4
cancer procoagulant 6.4
methylenetetrahydrofolate reductase 6.2
methylenetetrahydrofolate reductase 6.2
granzyme M 6.1
polo-like kinase 1 6.0
tissue plasminogen activator 6.0
neurosin 5.9
TSR 5.8
coagulation factor XIa 5.7
acetylornithinase 5.6
plasmin 5.6
fibrolase 5.5
ubiquitin-protein ligase 5.5
dolichol kinase 5.0
carboxypeptidase B 5.0
Delta6-desaturase 5.0
deoxyhypusine hydroxylase 4.9
tripeptidase 4.9
MHCK 4.8
CPN 4.7
Hageman factor 4.7
carboxypeptidase S 4.7
hepsin 4.7
hepsin 4.7
ancrod 4.7
caspase-5 4.7
ethanolamine ammonia-lyase 4.7
bleomycin hydrolase 4.6
TAT 4.6
prepilin peptidase 4.5
cystathionine beta-synthase 4.5
clotting enzyme 4.5
urokinase-type plasminogen activator 4.5
CGT 4.5
factor C 4.4
CYP8B1 4.4
aromatic amino acid aminotransferase 4.4
polypeptide N-acetylgalactosaminyltransferase 4.4
caspase-5 4.4
asparaginase 4.4
kallikrein 4.4
N-acetylglucosaminyltransferase III 4.3
SsuE 4.3
coagulation factor VIIa 4.3
cathepsin S 4.3
TGT 4.2
mannosidase I 4.2
peptidyl-tRNA hydrolase 4.2
stem bromelain 4.2
rhomboid protease 4.1
polyphosphatase 4.1
alpha-methylacyl-CoA racemase 4.1
ADE2 4.1
GTI 4.0
GSK 4.0
IgA protease 4.0
cdc2 3.9
C3b inactivator 3.9
PWD 3.9
cathepsin G 3.8
more...
Compound
1H-imidazo[4,5-b]pyrazine 9.9
C7H14O 9.9
C8H9N3O3 9.9
3H-[1,2,3]triazolo[4,5-b]pyridine 9.3
Aspidospermine 9.3
Aspidospermine 9.3
5-aminopentanoic acid 9.0
[1,2,4]triazolo[4,3-a]pyrazine 8.9
[1,2,4]triazolo[4,3-a]pyrimidine 8.6
[1,2,4]triazolo[4,3-c]pyrimidine 8.1
Nelfinavir mesylate 7.3
Factor X 7.2
Genkwanin 7.1
Thrombin 6.9
Ailanthone 6.8
FAP 6.8
FAP 6.8
DCC 6.7
Amarogentin 6.7
Ailanthone 6.5
Microcephalin 6.4
2-chlorobenzaldehyde 6.4
E09 6.4
E09 6.4
M 14 6.1
S.T.D. 6.0
Neohesperidin 5.9
Paraformaldehyde 5.9
Vitamin K 5.9
FDP 5.8
Caprolactam 5.8
K 10 5.8
Benzamidine 5.8
Stearidonic acid 5.8
2,5-piperazinedione 5.8
Fibrinogen 5.7
SN-38 5.7
Novex 5.6
Mafosfamide 5.6
Sulindac 5.6
Paraformaldehyde 5.6
1H-pyrazolo[3,4-d]pyrimidine 5.5
Avertin 5.5
Azoxymethane 5.5
Clemastine 5.5
C14H19N3O4 5.5
Warfarin 5.5
Fibrinopeptide A 5.5
Homoharringtonine 5.4
Oxytetracycline hydrochloride 5.3
Brucine 5.3
2-methyl-2-butanol 5.3
DIC 5.2
Pristimerin 5.2
Pristimerin 5.2
Pristimerin 5.2
Pristimerin 5.2
Lapachol 5.2
Alantolactone 5.1
Glucosylceramide 5.1
Thiazolidinedione 5.0
Pelargonidin 5.0
Desogestrel 5.0
5,5-dimethyl-1,3-cyclohexanedione 5.0
2,4,6-trichloro-1,3,5-triazine 5.0
PCI 4.9
10-Hydroxycamptothecin 4.9
TRU 4.9
CLTC 4.9
Garcinol 4.8
Urocanic acid 4.8
EPB 4.8
Leupeptin 4.8
Diisopropyl fluorophosphate 4.8
Vitamin K1 4.8
Coumarin 4.7
Tuberin 4.7
Dolichol 4.7
Argatroban 4.7
9Z,11E-octadecadienoic acid 4.7
more...