Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.69 (
APC
)
16,337
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
APC
8035
protein C
6318
thrombin
2049
protein S
2009
prothrombin
1274
Sep
1100
antithrombin
1029
antithrombin III
1022
thrombomodulin
946
Protein C
918
fibrinogen
917
p53
807
factor V
705
Mol
704
factor V Leiden
677
CD4
613
cytokine
539
TCR
519
MHC
495
thromboplastin
473
anaphase-promoting complex/cyclosome
451
beta-catenin
447
plasminogen
432
tissue factor
405
IFN-gamma
405
factor VIII
403
catenin
394
IL-2
380
CD8
377
factor Xa
360
MHC class II
357
ubiquitin
328
ubiquitin ligase
302
KRAS
302
Protein S
288
VIII
272
von Willebrand factor
259
serine protease
257
PLA
248
factor VII
248
more...
Disease
APC
8035
cancer
2198
tumor
1837
colorectal cancer
930
sepsis
683
sepsis
672
familial adenomatous polyposis
630
carcinogenesis
495
tumorigenesis
478
systemic lupus erythematosus
452
carcinoma
412
lupus
406
disseminated intravascular coagulation
394
deep vein thrombosis
393
lupus
362
colon cancer
348
stroke
312
adenoma
289
polyposis
282
coagulopathy
231
adenocarcinoma
225
pulmonary embolism
209
diabetes
197
breast cancer
179
purpura
166
antiphospholipid syndrome
166
tumor progression
156
myocardial infarction
144
ischemia
143
atherosclerosis
142
metastases
137
thrombocytopenia
135
tumor growth
132
hyperhomocysteinemia
126
PC deficiency
125
HIV
115
dysplasia
115
gastric cancer
114
Thrombophilia
111
hypertension
109
more...
Symptom
respiratory distress
63
pain
59
abdominal pain
44
headache
36
seizures
36
anesthesia
34
hypothermia
23
starvation
22
dyspnea
21
diarrhea
21
chest pain
19
collapse
19
vomiting
19
angina
19
erythema
18
weakness
16
splenomegaly
15
exhaustion
14
functional recovery
14
livedo
13
overweight
11
nausea
9
hemiplegia
8
hypotonia
7
dysarthria
6
shortness of breath
6
leg edema
6
hepatomegaly
6
paresis
6
hyperoxia
6
HSA
6
chills
6
lethargy
5
epigastric pain
5
fatigue
5
anorexia
5
tachypnea
5
analgesia
5
hepatosplenomegaly
4
back pain
4
more...
Drug
IFN-gamma
404
IL-2
380
CSF
94
lysine
78
Antithrombin III
72
Cardiovasc
69
Dermatol
60
Asn
45
Drotrecogin alfa
44
Drotrecogin alfa
44
PTC
42
Vitamin K
37
TAT
29
THF
28
CPT-11
24
CaCl2
22
CaCl2
22
CaCl2
22
Gel
21
Nephron
19
MAP
18
uPA
17
Irinotecan
17
Vitamin B12
15
Nephron
14
ROS
12
caffeine
12
Ximelagatran
12
Coumadin
10
G-CSF
10
Asthma
9
Fragment
9
Monit
9
CIA
9
Dial
8
ABC
8
DNase I
8
Aprotinin
8
ROC
8
Fraction
7
more...
Enzyme
APC
16337
thrombin
2009
thromboplastin
817
tissue plasminogen activator
359
ERK
273
plasmin
218
proteasome
202
protein kinase
198
mitogen-activated protein kinase
188
urokinase-type plasminogen activator
121
trypsin
118
focal adhesion kinase
95
methylenetetrahydrofolate reductase
80
methylenetetrahydrofolate reductase
80
protein kinase C
69
kallikrein
65
cdc2
65
lysozyme
56
GSK
55
peroxidase
54
polo-like kinase 1
50
chymotrypsin
47
STK11
45
RNA polymerase
45
calcineurin
44
ATPase
43
separase
42
luciferase
40
MEK
37
thrombin-activatable fibrinolysis inhibitor
36
caspase-3
36
asparaginase
29
TAT
29
catalase
28
elastase
28
neutrophil elastase
26
alkaline phosphatase
24
glutathione S-transferase
23
PARP
23
superoxide dismutase
22
more...
Compound
DNA
1490
Dec
1185
Clin
876
calcium
482
arginine
384
Thrombin
270
serine
229
sodium
186
lysine
177
sulfate
161
alanine
149
oxygen
146
tyrosine
144
water
137
TNF
135
glucose
133
homocysteine
127
DCC
127
His
114
cysteine
108
methionine
106
SDS
105
threonine
103
Asp
99
acetate
98
Gly
91
phosphate
90
leucine
87
nitrogen
81
Heparin
77
prostacyclin
72
nitric oxide
72
Phe
71
Fibrinogen
70
hydrogen
67
Cardiol
67
glutamine
67
NH2
64
ATP
64
ADP
61
more...