Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.69 (APC)
 16,337 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
APC 8035
protein C 6318
thrombin 2049
protein S 2009
prothrombin 1274
Sep 1100
antithrombin 1029
antithrombin III 1022
thrombomodulin 946
Protein C 918
fibrinogen 917
p53 807
factor V 705
Mol 704
factor V Leiden 677
CD4 613
cytokine 539
TCR 519
MHC 495
thromboplastin 473
anaphase-promoting complex/cyclosome 451
beta-catenin 447
plasminogen 432
IFN-gamma 405
tissue factor 405
factor VIII 403
catenin 394
IL-2 380
CD8 377
factor Xa 360
MHC class II 357
ubiquitin 328
KRAS 302
ubiquitin ligase 302
Protein S 288
VIII 272
von Willebrand factor 259
serine protease 257
PLA 248
factor VII 248
plasminogen activator inhibitor-1 248
IL-10 248
IL-4 244
cyclin 244
plasminogen activator inhibitor 242
Thrombomodulin 236
tissue plasminogen activator 230
myosin 225
CD28 221
adenomatous polyposis coli 206
endothelial protein C receptor 205
proteasome 200
glycoprotein 199
CTNNB1 196
IL-6 194
tissue factor pathway inhibitor 188
BRAF 180
PCI 176
E3 ubiquitin ligase 173
CD40 171
E-cadherin 169
MHC class I 168
LPS 159
p16 158
CD86 156
insulin 153
CDH1 153
lymphoid 150
TNF-alpha 149
factor IX 146
CD80 145
securin 143
tumor necrosis factor 143
HLA 142
heavy chain 137
PTEN 136
TNF 135
MLH1 134
epidermal growth factor 133
C4b-binding protein 132
K-ras 131
PIK3CA 128
DCC 127
IFN 125
BRCA1 121
lipopolysaccharide 118
C-reactive protein 117
RASSF1A 112
SMAD4 112
ICAM-1 110
urokinase-type plasminogen activator 108
collagen 106
Axin 105
Mad2 104
plasma protein C 103
cyclin B1 102
She 101
Prothrombin 101
SDS 100
heparin cofactor II 99
HLA-DR 97
MCC 97
SCF 97
CD11c 95
tumour suppressor 94
FVIII 94
CDKN2A 94
methylguanine-DNA methyltransferase 92
cyclin D1 92
polypeptide 89
IL-1 88
TCF 88
annexin V 85
MAPK 85
thymus 85
ras 84
hMLH1 83
MSH2 83
MUTYH 82
BRCA2 82
GSTP1 81
endoplasmic reticulum 80
CD25 79
hemoglobin 79
CD11b 78
methylenetetrahydrofolate reductase 78
albumin 77
ATM 77
phosphatase 77
vascular endothelium 77
TGF-beta 77
gut 76
EGFR 75
chemokine 75
membrane-bound 74
coagulation factor V 74
APC protein 74
Antithrombin III 72
PI3K 72
fused 71
CD45 70
MLR 70
p21 70
GM-CSF 68
Factor VIII 68
KEN 67
RB1 67
NMR 67
CD14 66
CD40L 65
LFA-1 65
MTHFR 65
histone 65
fibronectin 64
IL-5 64
ATP 64
reductase 62
EGF 62
CTLA-4 61
membrane protein 61
more...
Disease
APC 8035
cancer 2198
tumor 1837
colorectal cancer 930
sepsis 683
sepsis 672
familial adenomatous polyposis 630
carcinogenesis 495
tumorigenesis 478
systemic lupus erythematosus 452
carcinoma 412
lupus 406
disseminated intravascular coagulation 394
deep vein thrombosis 393
lupus 362
colon cancer 348
stroke 312
adenoma 289
polyposis 282
coagulopathy 231
adenocarcinoma 225
pulmonary embolism 209
diabetes 197
breast cancer 179
purpura 166
antiphospholipid syndrome 166
tumor progression 156
myocardial infarction 144
ischemia 143
atherosclerosis 142
metastases 137
thrombocytopenia 135
tumor growth 132
hyperhomocysteinemia 126
PC deficiency 125
dysplasia 115
HIV 115
gastric cancer 114
Thrombophilia 111
hypertension 109
Lyme disease 108
hepatocellular carcinoma 108
cirrhosis 100
SDS 100
Merkel cell carcinoma 97
influenza 91
hypertrophic cardiomyopathy 90
Lynch syndrome 90
leukemia 89
desmoid 89
preeclampsia 86
melanoma 86
obesity 86
lung cancer 85
ATM 83
virus infection 79
encephalomyelitis 78
prostate cancer 77
lymphoma 75
infectious diseases 72
Activated protein C resistance 72
autoimmune disease 72
inflammatory bowel disease 71
Severe sepsis 67
acute myocardial infarction 64
liver disease 63
cardiovascular disease 61
multiple sclerosis 61
abortion 60
Haemophilia 60
Protein C deficiency 59
ulcerative colitis 58
Lupus 57
vascular disease 57
haemophilia 56
anemia 53
asthma 51
Hippel 51
pneumonia 50
cold 50
colitis 50
plaque 49
nephrotic syndrome 49
ovarian cancer 49
malnutrition 48
arthritis 46
squamous cell carcinoma 46
Factor V Leiden mutation 46
multiple myeloma 45
heart failure 45
type 1 diabetes 45
Thrombus 45
non-small cell lung cancer 43
malaria 43
coronary artery disease 43
tetanus 42
Mycobacterium 42
cerebral infarction 42
primary tumor 41
Alzheimer's disease 41
vasculitis 41
pancreatic cancer 40
renal disease 40
retinoblastoma 40
HNPCC 39
rectal cancer 39
immunodeficiency 39
Blocking 39
Gardner's syndrome 38
tuberculosis 38
rheumatoid arthritis 37
Barrett's esophagus 37
hepatitis B 37
myocardial ischemia 37
Budd-Chiari syndrome 37
sickle cell disease 36
acute lymphoblastic leukemia 36
dysfibrinogenemia 35
Purpura fulminans 35
NOD 35
SCID 34
renal failure 33
thalassemia 33
portal hypertension 33
PHA 33
Crohn's disease 32
gangrene 31
adult respiratory distress syndrome 31
depression 31
thrombophlebitis 31
graft-versus-host disease 30
AIDS 30
coronary heart disease 30
Infection 29
tumor initiation 29
hereditary protein C deficiency 29
von Willebrand disease 29
hepatoblastoma 29
heart disease 28
cardiomyopathy 28
myeloproliferative disorders 28
pulmonary hypertension 28
hyperlipidemia 27
Hypertrophic cardiomyopathy 27
veno-occlusive disease 27
medulloblastoma 26
ARF 26
vitamin K deficiency 26
acute myeloid leukemia 26
papillary thyroid cancer 26
hepatitis C 26
Portal vein thrombosis 25
bladder cancer 25
Peutz-Jeghers syndrome 25
DVT 24
Best 24
chronic hepatitis 24
hepatitis 24
hemiparesis 24
WT1 24
more...
Symptom
respiratory distress 63
pain 59
abdominal pain 44
headache 36
seizures 36
anesthesia 34
hypothermia 23
starvation 22
diarrhea 21
dyspnea 21
vomiting 19
collapse 19
chest pain 19
angina 19
erythema 18
weakness 16
splenomegaly 15
exhaustion 14
functional recovery 14
livedo 13
overweight 11
nausea 9
hemiplegia 8
hypotonia 7
hepatomegaly 6
dysarthria 6
paresis 6
leg edema 6
chills 6
hyperoxia 6
shortness of breath 6
HSA 6
fatigue 5
tachypnea 5
anorexia 5
analgesia 5
epigastric pain 5
lethargy 5
dizziness 4
ataxia 4
hepatosplenomegaly 4
hemoptysis 4
back pain 4
colic 4
Livedoid 4
cough 3
cyanosis 3
sleepiness 3
syncope 3
discomfort 3
flushing 3
acidity 3
pallor 3
neuralgia 3
discomfort 3
leg pain 3
acute abdomen 3
chorea 2
spasm 2
exertional dyspnea 2
DNA marker 2
intestinal bleeding 2
Ill 2
Fluctuation 2
right upper quadrant pain 2
facial pain 2
arthralgia 2
spasticity 2
asthenia 2
anal pain 2
nausea and vomiting 2
pelvic pain 2
acute abdominal pain 2
vertigo 2
cachexia 2
hypoproteinemia 2
thinning 2
numbness 2
left upper quadrant pain 1
agitation 1
photophobia 1
constipation 1
stridor 1
hyperemesis 1
right lower quadrant pain 1
ophthalmoplegia 1
dystonia 1
acute stress 1
emaciation 1
dysesthesia 1
tinnitus 1
presyncope 1
torticollis 1
fasciculation 1
abnormal gait 1
memory loss 1
Spots 1
fever of unknown origin 1
flank pain 1
sore throat 1
clumsiness 1
tonic-clonic seizure 1
dry eye 1
Intermittent fever 1
regurgitation 1
myalgia 1
chest tightness 1
neck stiffness 1
cancer pain 1
Unexplained abdominal pain 1
hot flashes 1
Flare 1
Neurologic symptoms 1
eye pain 1
syncopal episodes 1
decreased appetite 1
impaired motor coordination 1
distraction 1
ENT 1
Organ failure 1
peri-menopausal 1
abdominal discomfort 1
muscle stiffness 1
low back pain 1
exertional angina 1
pedal edema 1
bloating 1
mastalgia 1
Drug
IFN-gamma 404
IL-2 380
CSF 94
lysine 78
Antithrombin III 72
Cardiovasc 69
Dermatol 60
Asn 45
Drotrecogin alfa 44
Drotrecogin alfa 44
PTC 42
Vitamin K 37
TAT 29
THF 28
CPT-11 24
CaCl2 22
CaCl2 22
CaCl2 22
Gel 21
Nephron 19
MAP 18
Irinotecan 17
uPA 17
Vitamin B12 15
Nephron 14
Ximelagatran 12
caffeine 12
ROS 12
G-CSF 10
Coumadin 10
Asthma 9
Fragment 9
CIA 9
Monit 9
ABC 8
Aprotinin 8
DNase I 8
Dial 8
ROC 8
ascorbate 7
Fraction 7
DDAVP 7
DDAVP 7
CTC 7
BLM 6
EE2 6
IL-11 6
EPA 6
LMWH 6
L-Asparaginase 6
NADH 6
DFP 6
CTC 6
ENT 6
Valdecoxib 6
Bevacizumab 5
Fondaparinux 5
PCP 5
IFN-beta 5
ACT 5
Lovastatin 5
nitroglycerin 5
vitamin E 5
Biopolymers 5
CCL 5
CAM 5
Alanine 4
Fragmin 4
Paraffin 4
Urokinase 4
TAC 4
Kaolin 4
ZnO 4
Parkin 4
p75 4
Parkin 4
ADR 4
Ancrod 4
Heme 4
Copaxone 4
CTX 4
L-tyrosine 4
Carotenoid 3
Imatinib 3
Vitamin E 3
Fluorescein 3
Norplant 3
Raloxifene 3
Gleevec 3
Phosphatidylserine 3
FAD 3
Dalteparin 3
Meth 3
Abatacept 3
TEL 3
MDS 3
ETS 3
Gefitinib 3
MOF 3
Asparaginase 3
Retinoic acid 3
Portal 3
citric acid 3
Nesiritide 3
-deoxyadenosine 3
CTA 3
Vioxx 3
Taxol 3
Bifidobacterium 3
Leaf 3
G418 3
Argatroban 3
EPI 3
Provenge 3
Phenprocoumon 3
ampicillin 2
Rasagiline 2
Spectrum 2
Calcipotriol 2
Natalizumab 2
Efalizumab 2
Cetuximab 2
CDX 2
Orgaran 2
Isotretinoin 2
ICI 2
Caspofungin 2
Warfarin sodium 2
Dextran sulfate sodium 2
IL-1ra 2
Imiquimod 2
Efalizumab 2
DEL 2
CFT 2
Glutathione 2
ALA 2
Triad 2
CDX 2
Ringer's solution 2
Epoetin 2
Intron A 2
Intron A 2
Streptokinase 2
Diphenhydramine 2
Edodekin alfa 2
MgSO4 2
Citric acid 2
TAK 2
Activin 2
Intron A 2
DMAP 2
Bayer 2
Zofenopril calcium 2
Ranitidine 2
Ranolazine 2
Ranolazine 2
Darbepoetin alfa 2
Mutagen 2
Zoledronic acid 2
PCB 2
more...
Enzyme
APC 16337
thrombin 2009
thromboplastin 817
tissue plasminogen activator 359
ERK 273
plasmin 218
proteasome 202
protein kinase 198
mitogen-activated protein kinase 188
urokinase-type plasminogen activator 121
trypsin 118
focal adhesion kinase 95
methylenetetrahydrofolate reductase 80
methylenetetrahydrofolate reductase 80
protein kinase C 69
cdc2 65
kallikrein 65
lysozyme 56
GSK 55
peroxidase 54
polo-like kinase 1 50
chymotrypsin 47
STK11 45
RNA polymerase 45
calcineurin 44
ATPase 43
separase 42
luciferase 40
MEK 37
thrombin-activatable fibrinolysis inhibitor 36
caspase-3 36
asparaginase 29
TAT 29
elastase 28
catalase 28
neutrophil elastase 26
alkaline phosphatase 24
glutathione S-transferase 23
PARP 23
superoxide dismutase 22
neuraminidase 21
phospholipase A2 20
tryptase 20
granzyme B 19
DNA polymerase 19
aspartate aminotransferase 19
alanine aminotransferase 18
ubiquitin-protein ligase 18
reverse transcriptase 17
CD10 16
AMPK 15
MAP 15
AMP-activated protein kinase 15
beta-galactosidase 15
NO synthase 15
SPC 13
cathepsin G 13
ACS 13
RNase 13
RNase 13
DNA methyltransferase 13
phosphatidylinositol 3-kinase 13
prostate-specific antigen 13
MMP 12
adenylate cyclase 12
endonuclease 11
carboxylesterase 11
glutathione peroxidase 11
cystathionine beta-synthase 11
MIP 11
BMT 11
protein phosphatase 2A 11
transcriptase 11
creatine kinase 10
lactate dehydrogenase 10
collagenase 10
CaMKII 10
carboxypeptidase B 10
phospholipase C 10
NADPH oxidase 9
kinesin 9
deaminase 9
NADPH oxidase 9
AMPK 9
ceruloplasmin 9
CYP3A4 9
ACE 9
cathepsin D 8
topoisomerase 8
hyaluronidase 8
PNGase F 8
tissue kallikrein 8
thymidine kinase 8
factor C 7
topoisomerase 7
cathepsin B 7
gamma-glutamyl transpeptidase 7
Hageman factor 7
proteinase K 7
chondroitinase 7
chondroitinase 7
renin 7
caspase-8 6
hexosaminidase 6
endoglycosidase H 6
glutaminase 6
phosphodiesterase 6
phosphoinositide 3-kinase 6
CPN 6
glutamine synthetase 6
ricin 6
glycine reductase 6
glucose-6-phosphate dehydrogenase 5
CGT 5
furin 5
NQO1 5
complex I 5
CPT 5
thyroid peroxidase 5
dihydrofolate reductase 5
chloramphenicol acetyltransferase 5
ATP synthase 5
lipase 5
papain 5
PDK1 5
TSR 5
tyrosinase 5
TGT 5
cathepsin S 5
pepsin 5
cathepsin L 5
acetylcholinesterase 5
CD13 5
PCP 5
cholinesterase 5
methane monooxygenase 5
ornithine decarboxylase 4
caspase-9 4
histidine kinase 4
glyceraldehyde-3-phosphate dehydrogenase 4
type III procollagen 4
ribonuclease 4
P-glycoprotein 4
ribonuclease 4
CPT 4
matrix metalloproteinase 2 4
cancer procoagulant 4
alpha-amylase 4
CPT 4
caspase-1 4
phosphorylase 4
insulin-degrading enzyme 4
DNA ligase 4
DNA ligase 4
TSA 4
histone acetyltransferase 4
glyceraldehyde-3-phosphate dehydrogenase 4
S1 nuclease 4
arginase 4
cytochrome oxidase 4
more...
Compound
DNA 1490
Dec 1185
Clin 876
calcium 482
arginine 384
Thrombin 270
serine 229
sodium 186
lysine 177
sulfate 161
alanine 149
oxygen 146
tyrosine 144
water 137
TNF 135
glucose 133
DCC 127
homocysteine 127
His 114
cysteine 108
methionine 106
SDS 105
threonine 103
Asp 99
acetate 98
Gly 91
phosphate 90
leucine 87
nitrogen 81
Heparin 77
prostacyclin 72
nitric oxide 72
Phe 71
Fibrinogen 70
Cardiol 67
glutamine 67
hydrogen 67
NH2 64
ATP 64
ADP 61
Warfarin 60
urea 58
FAP 58
FAP 58
ADP 52
ADP 52
salt 52
DIC 51
EDTA 50
PMA 48
cAMP 45
PMA 44
Ile 43
galactose 42
EDTA 41
zinc 41
creatinine 40
barium 39
glutamic acid 38
Vitamin K 37
iron 36
Factor X 36
proline 35
retinoic acid 32
TEM 32
PEG 31
NKT 31
PCI 30
copper 29
COS 29
FDP 29
SN-38 29
MEK 28
THP 28
MTT 28
THP 28
tryptophan 28
Estrogen 27
iodine 27
ammonium 25
glutamate 25
CPT-11 24
tryptophan 24
tryptophan 24
tryptophan 24
aspartic acid 22
CaCl2 22
ASA 21
Fibrin 21
aspartic acid 21
aspartic acid 21
aspartic acid 21
MDA 21
Ubiquitin 20
GTP 20
Optimal 20
DEAE 20
PEG 19
PGE2 19
DBA 18
5-aminopentanoic acid 18
manganese 17
BCR 17
DBA 17
bromide 17
DBA 17
potassium 16
glycerol 15
methanol 15
HCl 15
Homocysteine 15
MAP 15
PGE 15
Homocysteine 15
ACS 15
vitamin D 14
asparagine 14
silver 14
Tris 13
CO2 13
TAP 13
Insulin 13
TOF 13
ACS 13
Coumarin 13
CAT 13
formaldehyde 13
CAT 13
CAT 13
Cbl 13
AMP 12
Tris 12
aldehyde 12
Histone 12
caffeine 12
valine 12
aldehyde 12
NAD 12
TNM 12
Pac 12
ethanol 12
pyridine 11
isoleucine 11
2-mercaptoethanol 11
TPA 11
TAA 11
APS 11
isoleucine 11
TPA 11
Mg2+ 10
BCG 10
PLP 9
H2O2 9
NAD 9
aluminum 9
PMSF 9
DSS 9
COX 9
Thyroid 9
hexose 9
more...