Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.69 (
APC
)
16,337
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alzheimer's disease-related presenilins are thought to be involved in Notch signaling during embryonic development and/or cellular differentiation. Proteins mediating the cellular functions of the presenilins are still unknown. We utilized the yeast two-hybrid system to identify an interacting armadillo protein, termed
p0071
, that binds specifically to the hydrophilic loop of presenilin 1. In vivo, the presenilins constitutively undergo proteolytic processing, forming two stable fragments. Here, we show that the C-terminal fragment of presenilin 1 directly binds to
p0071
. Nine out of 10 armadillo repeats in
p0071
are essential for mediating this interaction. Since armadillo proteins, like beta-catenin and
APC
, are known to participate in cellular signaling,
p0071
may function as a mediator of presenilin 1 in signaling events.
...
PMID:Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. 1009 85
