Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.69 (
APC
)
16,337
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although approximately 100 deubiquitinating enzymes (DUBs) are encoded in the human genome, very little is known about the DUBs that function in mitosis. Here, we demonstrate that DUB
USP35
functions as a mitotic regulator by controlling the protein levels and downstream signaling of Aurora B and the depletion of
USP35
eventually leads to several mitotic defects including cytokinesis failures.
USP35
binds to and deubiquitinates Aurora B, and inhibits the
APC
CDH1
-mediated proteasomal degradation of Aurora B, thus maintaining its steady-state levels during mitosis. In addition, the loss of
USP35
decreases the phosphorylation of histone H3-Ser10, an Aurora B substrate. Finally, the transcription factor FoxM1 promotes the expression of
USP35
, as well as that of Aurora B, during the cell cycle. Our findings suggest that
USP35
regulates the stability and function of Aurora B by blocking
APC
CDH1
-induced proteasomal degradation, thereby controlling mitotic progression.
...
PMID:USP35 regulates mitotic progression by modulating the stability of Aurora B. 2944 77
