Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Query: EC:3.4.21.69 (
APC
)
16,337
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Engagement of a T cell to an
APC
induces the formation of an immunological synapse as well as reorientation of the microtubule-organizing center (MTOC) toward the
APC
. How signals emanating from the TCR induce MTOC polarization is not known. One group of proteins known to play a critical role in asymmetric cell division and cell polarization is the partitioning defective (Par) family of proteins. In this study we found that
Par1b
, a member of the Par family of proteins, was inducibly phosphorylated following TCR stimulation. This phosphorylation resulted in 14-3-3 protein binding and caused the relocalization of
Par1b
from the membrane into the cytoplasm. Because a dominant-negative form of
Par1b
blocked TCR-induced MTOC polarization, our data suggest that
Par1b
functions in the establishment of T cell polarity following engagement to an
APC
.
...
PMID:The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. 1955 22
