Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.21.69 (APC)
 16,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The anatomical location and appearance of retinal hemorrhages in the infant provide important clues in the diagnosis of underlying disorders. While neonatal retinal hemorrhages related to birth trauma are common, benign, and self-limited, other retinal hemorrhages in infancy may signify intracranial aneurysms, accidental or non-accidental injury, and a variety of ocular (e.g., Coats' disease, PHPV, ROP, retinal dysplasia, hypertension, myopia) or systemic disease (e.g., hematologic or cardiovascular disorders, infection, protein C deficiency). In this review, retinal hemorrhages are illustrated and classified according to location, appearance, and etiology. Prompt diagnosis of retinal hemorrhages in infants is crucial, because treatment may be required to prevent early deprivation amblyopia and blindness. Ophthalmological findings may also be a valuable contribution to the overall medical evaluation of the infant.
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PMID:Fundus hemorrhages in infancy. 150 54

A premature infant who developed central retinal vein obstruction in one eye during laser therapy for high-risk prethreshold retinopathy of prematurity is described. Systemic investigations were done to detect the cause of such an acute and unreported episode. Acquired deficiency of protein C levels was detected. Premature infants are at risk of thromboembolic episodes due to deranged hematological parameters. Acquired protein C deficiency possibly precipitated acute retinal vein occlusion during laser therapy in this infant. Intravitreal bevacizumab was used successfully to treat the episode of retinal venous occlusion. Retinal vein obstruction during laser treatment for retinopathy of prematurity is reported for the first time.
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PMID:Central retinal vein obstruction in a neonate occurring during laser photocoagulation treatment for retinopathy of prematurity. 2542 39