Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.69 (
APC
)
16,337
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
More than thirty kinds of mutant or knockout mice bearing
intestinal neoplasm
have been reported up to the present. Apc(Min/+) mouse holding multiple intestinal neoplasia, provides an appropriate model to evaluate human familial adenomatous polyposis.
APC
is an important tumor-suppressor gene in the Wnt pathway, which is involved in the pivotal signal transduction cascade in animal embryogenesis and colorectal carcinogenesis. Apc(Min/+) mouse model was presented as aspects of the strain background, genotype/phenotype, divergent canonical Wnt signaling pathway, methylation of tumor-suppressor gene, TGF-b signaling pathway and multidrug resistance gene, etc. This review also introduced the application and signification of the mouse model in studies of anti-colorectal tumor drugs.
...
PMID:[Use of Apc(Min/+) mouse model in the studies of intestinal tumors]. 1833 93
