Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.68 (tissue plasminogen activator)
 11,311 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
tissue plasminogen activator 11.5
tissue plasminogen activator precursor 11.5
tPA 11.5
u-PA 10.5
rho GTPase activating protein 10.5
SERPINE2 protein 10.5
C9orf46 10.5
plasmin precursor 10.5
LRP-DIT 10.5
Neuroserpin 10.1
PLA 9.9
TMPRSS5 9.9
neuroserpin 9.8
plasminogen activator inhibitor 9.8
PAI-2 9.7
PAI 9.5
plasminogen activator inhibitor-1 9.5
EIF-4E 9.5
gene trap ankyrin repeat 9.5
spinesin 9.5
Plasminogen 9.4
Tissue plasminogen activator 9.4
plasminogen 9.3
alpha 2-plasmin inhibitor 9.3
ETNK2 9.1
urokinase-type plasminogen activator 9.0
thrombin-activatable fibrinolysis inhibitor 9.0
plasminogen-like 9.0
tripartite motif-containing 22 8.9
C-type lectin domain family 3 member A 8.9
N-acetylneuraminate pyruvate lyase 8.9
DLP3 8.9
Plasmin 8.8
PLAT 8.8
PRSS12 8.7
tryptase epsilon 8.7
inhibitor-1 8.6
urokinase plasminogen activator 8.6
PAI1 8.6
normal epithelial cell-specific 1 8.6
SPRR2B 8.5
plasminogen activator inhibitor 2 8.3
SLC25A26 8.3
AP-2 like 8.3
kallikrein 8 8.1
CD39L3 8.1
calcium-response factor 8.1
neurotrypsin 8.1
histidine-rich glycoprotein 8.1
Cytoskeleton-associated protein 4 8.0
SK 1 8.0
FAPA 7.9
S100A10 protein 7.9
TTDN1 7.9
BENE 7.9
plasminogen activator, urokinase 7.8
PRAP 7.8
thrombomodulin 7.8
WFIKKN1 7.8
UEF 7.8
FDP 7.8
Urokinase plasminogen activator 7.7
Neuropsin 7.7
annexin A2 7.7
lipoprotein receptor-related protein 7.7
Insulin-like growth factor-binding protein 5 7.7
GANC 7.7
annexin II 7.6
SERP1 7.6
V2-6 7.6
Tissue factor pathway inhibitor-2 7.5
Fibrinopeptide A 7.5
STAMBP 7.5
antithrombin III 7.4
tissue factor pathway inhibitor 7.4
heparin cofactor II 7.4
neuropsin 7.4
NAD-dependent methylenetetrahydrofolate dehydrogenase 7.4
Coagulation factor VII 7.4
endoglycan 7.4
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Disease
Saddle PE 10.5
Vascular thoracic outlet syndrome 9.9
Coronary artery reocclusion 9.9
Subretinal hemorrhage 9.5
Livedo vasculitis 9.5
Systemic fibrinogenolysis 9.5
Acute transmural myocardial infarction 9.5
Corticosteroid-induced glaucoma 9.5
Pleural infection 9.3
Congenital dysfibrinogenemia 9.3
Pulmonary artery thrombosis 9.3
Brain Ischemia 9.2
FENIB 9.1
Post MI 9.1
PLAT 8.8
Livedoid vasculitis 8.8
Suprachoroidal hemorrhage 8.7
Acute coagulopathy 8.7
Acute Stroke 8.5
Embolic stroke 8.5
Recurrent pulmonary embolism 8.4
Plastic bronchitis 8.4
Staphylococcal endocarditis 8.3
Choroidal neovascular membrane 8.0
coronary thrombosis 7.9
Acute massive pulmonary embolism 7.7
Transmural myocardial infarction 7.7
Retinal atrophy 7.7
HPC4 7.6
Anaphylactoid reaction 7.5
dysfibrinogenemia 7.5
Ischemic stroke 7.4
Plasminogen deficiency 7.4
Aortic valve sclerosis 7.4
Essential mixed cryoglobulinemia 7.4
XDP 7.1
Thrombus 6.9
global aphasia 6.8
Decompensated cirrhosis 6.8
Locked-in syndrome 6.8
Middle cerebral artery occlusion 6.8
Dengue Shock Syndrome 6.8
A-V malformation 6.7
cerebrovascular occlusion 6.7
venous stasis 6.7
Central retinal artery occlusion 6.7
postphlebitic syndrome 6.7
Phlegmasia cerulea dolens 6.6
hepatic veno-occlusive disease 6.6
Pulmonary arteriovenous fistula 6.5
Spinal epidural hematoma 6.5
Ligneous conjunctivitis 6.4
Rheumatoid vasculitis 6.3
Withdrawal bleeding 6.3
hypofibrinogenemia 6.3
Posterior vitreous detachment 6.3
DWI 6.2
AAPC 6.2
Geographic atrophy 6.2
veno-occlusive disease 6.2
acute myocardial infarction 6.2
Hughes syndrome 6.2
PLG 6.1
clotting factor deficiency 6.1
coronary artery embolism 6.1
Hypervitaminosis A 6.1
tuberculous effusion 6.1
cerebral hematoma 6.1
GFD 6.1
verruga peruana 6.0
homocystinemia 6.0
Extrahepatic cholestasis 6.0
Thrombophilia 6.0
Prehypertension 5.9
Neonatal encephalopathy 5.9
Cerebral hyperperfusion syndrome 5.9
cerebral embolism 5.9
Atrial myxoma 5.8
Hemophilic arthropathy 5.8
Q wave MI 5.7
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Symptom
Upper back pain 8.9
Lower extremity weakness 8.5
Mental status changes 7.2
facial droop 7.1
finger pain 6.2
Livedoid 5.8
thoracic back pain 5.7
disturbed balance 5.6
neurological disability 4.8
localized edema 4.7
monoplegia 4.7
consciousness disturbance 4.4
hemiplegia 4.4
chest pain 4.1
dysarthria 4.0
arm weakness 3.9
livedo 3.7
exertional angina 3.5
functional recovery 3.5
non-productive cough 3.3
dark urine 3.3
pleuritic chest pain 3.3
Fluctuation 3.2
presyncope 3.2
persistent cough 3.2
angina 3.2
dysesthesia 3.2
forgetfulness 3.1
hypothermia 2.9
Scratch 2.8
rigors 2.8
orthopnea 2.6
paraparesis 2.6
hyperoxia 2.6
stomach pain 2.5
tachypnea 2.5
Catch 2.5
POA 2.4
clumsiness 2.4
flank pain 2.4
hyperemesis gravidarum 2.4
Anoxia 2.4
shortness of breath 2.3
neck stiffness 2.2
respiratory distress 2.2
atypical chest pain 2.1
spasm 2.1
nasal discharge 2.0
blurred vision 2.0
syncope 2.0
cyanosis 1.9
neck pain 1.8
intestinal bleeding 1.8
renal colic 1.8
exertional dyspnea 1.7
numbness 1.7
neuralgia 1.7
incoordination 1.7
acute stress 1.6
dyspnea 1.5
pelvic pain 1.5
overweight 1.5
leg pain 1.5
weakness 1.4
chills 1.4
productive cough 1.3
hypoproteinemia 1.3
stridor 1.3
facial pain 1.3
night sweats 1.2
dental pain 1.2
hemoptysis 1.2
tonic-clonic seizure 1.1
hepatomegaly 1.0
photophobia 0.8
flushing 0.8
dizziness 0.8
regurgitation 0.8
epigastric pain 0.7
back pain 0.7
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Drug
Cyclotheonamide A 11.5
Pamiteplase 11.1
Prolyse 10.7
Lanoteplase 10.7
Monteplase 10.7
Desmoteplase 10.5
Activase 10.3
Alteplase 10.1
Alteplase 10.0
Alteplase 10.0
Actimmune 9.9
Tenecteplase 9.2
uPA 9.0
Trafermin 8.9
Streptokinase 8.8
Urokinase 8.5
Sibrafiban 8.3
Sulotroban 8.1
Hirulog 7.7
Ancrod 7.6
Argatroban 7.2
Batroxobin 7.1
Foscavir 7.0
Diastat 7.0
Ecallantide 7.0
Desmopressin acetate 7.0
DDAVP 7.0
DDAVP 6.9
Calciparine 6.8
Adenosine Monophosphate 6.6
Cyclandelate 6.5
Acadesine 6.5
Ridogrel 6.5
CGS 13080 6.4
Thrombostat 6.4
Optison 6.3
Polyacrylic acid 6.2
LCBF 6.2
Pulmozyme 6.1
Aprotinin 6.1
Iopromide 6.0
C3F8 6.0
Eptifibatide 5.9
Antithrombin III 5.9
Optison 5.9
CS-514 5.8
Abciximab 5.8
Beraprost 5.7
Chloramine T 5.6
Tiaprofenic acid 5.5
Nafamostat mesilate 5.5
Orgaran 5.3
Dalteparin 5.3
Omapatrilat 5.3
TAT 5.2
Enalaprilat 5.2
Gliclazide 5.2
DFP 5.2
Enalaprilat 5.2
Hyoscyamine 5.2
Trental 5.2
Cangrelor 5.1
Gemfibrozil 5.1
Dazoxiben 5.0
Cilnidipine 5.0
Azacytidine 4.9
Fragmin 4.9
Ranibizumab 4.8
Iloprost 4.7
Icodextrin 4.7
Fondaparinux 4.7
Poloxamer 188 4.7
Coumadin 4.6
CA-074 4.6
Red ginseng 4.6
Poudre 4.6
SF6 4.5
Aliskiren 4.4
LMWH 4.4
Cilostazol 4.4
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Enzyme
tissue plasminogen activator 11.5
thrombin-activatable fibrinolysis inhibitor 9.3
kyotorphin synthetase 9.1
urokinase-type plasminogen activator 9.1
plasmin 8.9
complement subcomponent C1r 8.7
ancrod 8.1
NS protease 7.5
neuropsin 7.4
carboxypeptidase B 7.2
destabilase 7.2
fibrolase 7.0
neuropsin 7.0
thrombin 6.5
neurosin 6.4
CPN 6.0
clotting enzyme 6.0
thromboplastin 6.0
APC 6.0
macrophage elastase 5.9
kallikrein 5.7
protease La 5.5
deoxyribonuclease 5.4
deoxyribonuclease 5.3
hepsin 5.3
hepsin 5.3
matrix metalloproteinase 9 5.3
tissue kallikrein 5.3
STK 5.2
TAT 5.2
ADPase 5.2
protein L-isoaspartyl methyltransferase 5.2
Hageman factor 5.0
thromboxane synthase 4.9
cancer procoagulant 4.9
MMP-3 4.9
coagulation factor VIIa 4.8
LMT 4.7
site-1 protease 4.7
cathepsin G 4.6
neutrophil elastase 4.6
matrix metalloproteinase 2 4.6
interstitial collagenase 4.6
versatile peroxidase 4.6
matriptase 4.5
elastase 4.4
MMP 4.4
heparinase 4.3
PNGase F 4.2
apyrase 4.2
jararhagin 4.2
endoglycosidase H 4.1
matriptase 4.1
cathepsin H 3.9
glucosidase II 3.9
histamine N-methyltransferase 3.9
triose-phosphate isomerase 3.9
FAST 3.9
chondroitinase 3.8
succinyl-CoA synthetase 3.8
lambda exonuclease 3.8
aminopeptidase A 3.7
aspartase 3.7
factor C 3.7
chondroitinase 3.7
factor D 3.7
chymase 3.7
DNase 3.6
trypsin 3.6
cathepsin D 3.6
type III procollagen 3.6
chymosin 3.6
GAR 3.5
PHT 3.5
enolase 3.5
tryptase 3.5
chymotrypsin 3.5
C3b inactivator 3.4
phosphoribulokinase 3.4
BMT 3.4
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Compound
1,3,7-Trihydroxyxanthone 11.5
Scolymoside 9.5
Promazine hydrochloride 9.5
AEK 9.4
5-amino-2-naphthalenesulfonic acid 9.1
Plasmin 9.0
FCB 8.7
6-aminohexanoic acid 8.5
6-aminohexanoic acid 8.5
Ginkgolide C 8.5
N-methylpropanamide 8.0
diphenyl phosphonate 7.9
Ginkgolide J 7.9
Methacycline 7.8
Fibrinopeptide A 7.7
Piperlonguminine 7.7
FDP 7.6
Ginkgolide C 7.6
Fibrin 7.6
2,3-dinor-thromboxane 7.2
Tranexamic acid 7.2
Fibrinogen 7.2
cyclooctanone 7.1
Argatroban 7.1
4-fluorotryptophan 7.1
cyclooctanone 7.1
Edaravone 6.9
Pipecolic acid 6.9
cycloheptanone 6.8
Methyl isocyanate 6.8
Droloxifene 6.6
Ginkgolide A 6.6
EGT 6.6
8-quinolinyl 6.6
Bullatacin 6.6
Chondroitin 6-sulfate 6.6
Stanozolol 6.5
15-Hydroxyeicosatetraenoic acid 6.5
6-Keto-PGF1a 6.4
Stanozolol 6.4
Tirofiban 6.4
Thrombin 6.4
piperidine-2-carboxylic acid 6.4
Caprolactam 6.3
9-cis-Retinoic acid 6.3
Stanozolol 6.3
15(S)-HPETE 6.3
Valyl 6.2
NS 1619 6.1
Desmopressin 6.1
Homocysteine thiolactone 5.8
Enalaprilat 5.8
COA 5.7
Factor X 5.7
Glycerophosphocholine 5.7
Fucoidan 5.6
Pelargonidin 5.6
Fluvastatin 5.4
TPA 5.4
Heparin 5.4
Mr 30 5.4
NH4OH 5.3
Phloroglucinol 5.3
Diisopropyl fluorophosphate 5.3
Benzamidine 5.3
cyclohexanecarboxylic acid 5.3
cyclohexanecarboxylic acid 5.3
cyclohexanecarboxylic acid 5.3
cyclohexanecarboxylic acid 5.3
cyclohexanecarboxylic acid 5.2
Fosinopril 5.2
PAR 5.2
TPA 5.2
Phloroglucinol 5.2
cholest-5-ene 5.1
Trigonelline 5.1
11-dehydro-thromboxane 4.9
prostacyclin 4.8
5-fluorotryptophan 4.8
1,8-octanediol 4.8
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