Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.68 (tissue plasminogen activator)
 11,311 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
tissue plasminogen activator 11.5
tPA 11.5
tissue plasminogen activator precursor 11.5
u-PA 10.5
C9orf46 10.5
SERPINE2 protein 10.5
rho GTPase activating protein 10.5
LRP-DIT 10.5
plasmin precursor 10.5
Neuroserpin 10.1
PLA 9.9
TMPRSS5 9.9
neuroserpin 9.8
plasminogen activator inhibitor 9.8
PAI-2 9.7
PAI 9.5
plasminogen activator inhibitor-1 9.5
gene trap ankyrin repeat 9.5
spinesin 9.5
EIF-4E 9.5
Plasminogen 9.4
Tissue plasminogen activator 9.4
plasminogen 9.3
alpha 2-plasmin inhibitor 9.3
ETNK2 9.1
urokinase-type plasminogen activator 9.0
thrombin-activatable fibrinolysis inhibitor 9.0
plasminogen-like 9.0
tripartite motif-containing 22 8.9
N-acetylneuraminate pyruvate lyase 8.9
C-type lectin domain family 3 member A 8.9
DLP3 8.9
Plasmin 8.8
PLAT 8.8
PRSS12 8.7
tryptase epsilon 8.7
inhibitor-1 8.6
urokinase plasminogen activator 8.6
PAI1 8.6
normal epithelial cell-specific 1 8.6
more...
Disease
Saddle PE 10.5
Vascular thoracic outlet syndrome 9.9
Coronary artery reocclusion 9.9
Subretinal hemorrhage 9.5
Livedo vasculitis 9.5
Acute transmural myocardial infarction 9.5
Corticosteroid-induced glaucoma 9.5
Systemic fibrinogenolysis 9.5
Pleural infection 9.3
Pulmonary artery thrombosis 9.3
Congenital dysfibrinogenemia 9.3
Brain Ischemia 9.2
FENIB 9.1
Post MI 9.1
PLAT 8.8
Livedoid vasculitis 8.8
Acute coagulopathy 8.7
Suprachoroidal hemorrhage 8.7
Acute Stroke 8.5
Embolic stroke 8.5
Recurrent pulmonary embolism 8.4
Plastic bronchitis 8.4
Staphylococcal endocarditis 8.3
Choroidal neovascular membrane 8.0
coronary thrombosis 7.9
Acute massive pulmonary embolism 7.7
Retinal atrophy 7.7
Transmural myocardial infarction 7.7
HPC4 7.6
Anaphylactoid reaction 7.5
dysfibrinogenemia 7.5
Ischemic stroke 7.4
Aortic valve sclerosis 7.4
Essential mixed cryoglobulinemia 7.4
Plasminogen deficiency 7.4
XDP 7.1
Thrombus 6.9
global aphasia 6.8
Decompensated cirrhosis 6.8
Locked-in syndrome 6.8
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Symptom
Upper back pain 8.9
Lower extremity weakness 8.5
Mental status changes 7.2
facial droop 7.1
finger pain 6.2
Livedoid 5.8
thoracic back pain 5.7
disturbed balance 5.6
neurological disability 4.8
localized edema 4.7
monoplegia 4.7
consciousness disturbance 4.4
hemiplegia 4.4
chest pain 4.1
dysarthria 4.0
arm weakness 3.9
livedo 3.7
exertional angina 3.5
functional recovery 3.5
non-productive cough 3.3
dark urine 3.3
pleuritic chest pain 3.3
Fluctuation 3.2
presyncope 3.2
persistent cough 3.2
angina 3.2
dysesthesia 3.2
forgetfulness 3.1
hypothermia 2.9
Scratch 2.8
rigors 2.8
orthopnea 2.6
paraparesis 2.6
hyperoxia 2.6
stomach pain 2.5
tachypnea 2.5
Catch 2.5
POA 2.4
clumsiness 2.4
flank pain 2.4
more...
Drug
Cyclotheonamide A 11.5
Pamiteplase 11.1
Prolyse 10.7
Lanoteplase 10.7
Monteplase 10.7
Desmoteplase 10.5
Activase 10.3
Alteplase 10.1
Alteplase 10.0
Alteplase 10.0
Actimmune 9.9
Tenecteplase 9.2
uPA 9.0
Trafermin 8.9
Streptokinase 8.8
Urokinase 8.5
Sibrafiban 8.3
Sulotroban 8.1
Hirulog 7.7
Ancrod 7.6
Argatroban 7.2
Batroxobin 7.1
Ecallantide 7.0
Foscavir 7.0
Diastat 7.0
Desmopressin acetate 7.0
DDAVP 7.0
DDAVP 6.9
Calciparine 6.8
Adenosine Monophosphate 6.6
Cyclandelate 6.5
Acadesine 6.5
Ridogrel 6.5
CGS 13080 6.4
Thrombostat 6.4
Optison 6.3
Polyacrylic acid 6.2
LCBF 6.2
Pulmozyme 6.1
Aprotinin 6.1
more...
Enzyme
tissue plasminogen activator 11.5
thrombin-activatable fibrinolysis inhibitor 9.3
kyotorphin synthetase 9.1
urokinase-type plasminogen activator 9.1
plasmin 8.9
complement subcomponent C1r 8.7
ancrod 8.1
NS protease 7.5
neuropsin 7.4
carboxypeptidase B 7.2
destabilase 7.2
fibrolase 7.0
neuropsin 7.0
thrombin 6.5
neurosin 6.4
CPN 6.0
clotting enzyme 6.0
thromboplastin 6.0
APC 6.0
macrophage elastase 5.9
kallikrein 5.7
protease La 5.5
deoxyribonuclease 5.4
deoxyribonuclease 5.3
hepsin 5.3
hepsin 5.3
matrix metalloproteinase 9 5.3
tissue kallikrein 5.3
STK 5.2
TAT 5.2
ADPase 5.2
protein L-isoaspartyl methyltransferase 5.2
Hageman factor 5.0
thromboxane synthase 4.9
cancer procoagulant 4.9
MMP-3 4.9
coagulation factor VIIa 4.8
LMT 4.7
site-1 protease 4.7
cathepsin G 4.6
more...
Compound
1,3,7-Trihydroxyxanthone 11.5
Promazine hydrochloride 9.5
Scolymoside 9.5
AEK 9.4
5-amino-2-naphthalenesulfonic acid 9.1
Plasmin 9.0
FCB 8.7
6-aminohexanoic acid 8.5
6-aminohexanoic acid 8.5
Ginkgolide C 8.5
N-methylpropanamide 8.0
diphenyl phosphonate 7.9
Ginkgolide J 7.9
Methacycline 7.8
Fibrinopeptide A 7.7
Piperlonguminine 7.7
FDP 7.6
Ginkgolide C 7.6
Fibrin 7.6
2,3-dinor-thromboxane 7.2
Tranexamic acid 7.2
Fibrinogen 7.2
cyclooctanone 7.1
Argatroban 7.1
cyclooctanone 7.1
4-fluorotryptophan 7.1
Edaravone 6.9
Pipecolic acid 6.9
cycloheptanone 6.8
Methyl isocyanate 6.8
Droloxifene 6.6
Ginkgolide A 6.6
8-quinolinyl 6.6
EGT 6.6
Bullatacin 6.6
Chondroitin 6-sulfate 6.6
Stanozolol 6.5
15-Hydroxyeicosatetraenoic acid 6.5
6-Keto-PGF1a 6.4
Stanozolol 6.4
more...