Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.68 (tissue plasminogen activator)
 11,311 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
tissue plasminogen activator 6267
PLA 5663
plasminogen 2292
urokinase-type plasminogen activator 1827
plasminogen activator inhibitor-1 1612
fibrinogen 1300
plasminogen activator inhibitor 1281
tPA 1232
thrombin 1089
Sep 795
Plasminogen 443
von Willebrand factor 403
antithrombin III 342
prothrombin 341
PAI 298
Mol 285
protein C 273
u-PA 268
insulin 252
serine protease 244
antithrombin 239
tissue factor 232
thrombomodulin 222
thromboplastin 208
collagen 204
SDS 176
urokinase plasminogen activator 163
fibronectin 161
glycoprotein 161
Plasmin 154
inhibitor-1 152
protein S 151
factor VII 145
matrix metalloproteinase 145
PAI-2 138
C-reactive protein 123
cytokine 114
tumor necrosis factor 113
bradykinin 110
factor VIII 110
factor Xa 108
Tissue plasminogen activator 107
MMP-9 106
vascular endothelium 103
ADP 100
TPA 99
Lp(a) 98
uPAR 94
alpha 2-plasmin inhibitor 93
penumbra 91
vitronectin 89
albumin 86
epidermal growth factor 86
She 84
MMP-2 83
MRI 79
TNF 75
thrombin-activatable fibrinolysis inhibitor 74
tissue factor pathway inhibitor 74
annexin II 72
polypeptide 71
kallikrein 71
serine protease inhibitor 70
vWF 67
HDL 67
FDP 67
hemoglobin 66
vascular endothelial growth factor 64
neuroserpin 64
lipopolysaccharide 62
VIII 61
brain-derived neurotrophic factor 60
GPIIb 60
lipoprotein receptor-related protein 59
beta-thromboglobulin 59
fused 59
IL-6 57
renin 56
Pol 56
factor XII 55
thrombin inhibitor 54
EPA 54
P-selectin 51
metalloproteinase 50
interleukin-6 50
angiotensin II 46
AMP 44
casein 42
protease inhibitor 41
heparin cofactor II 40
endothelin-1 39
erythropoietin 39
VEGF 38
chymotrypsin 38
collagenase 38
platelet factor 4 38
heavy chain 37
ERK1 37
FSH 37
TGF-beta 35
annexin A2 35
adhesion molecule 35
trypsin inhibitor 35
serum albumin 34
axonal 34
E-selectin 34
Factor VIII 34
PAR 34
NMR 33
low-density lipoprotein receptor 33
Neuroserpin 33
factor V 33
Protein C 33
CPU 32
TAT 32
MMP-1 32
nexin 32
glycoprotein IIb 32
carboxypeptidase B 32
Prothrombin 31
MAPK 31
NMDA receptor 31
ACE 31
LPS 30
MMP9 30
beta 1 30
creatine kinase 30
nitric oxide synthase 29
vascular cell adhesion molecule-1 29
TNF-alpha 29
ATP 29
CRP 28
C1 inhibitor 28
MMP 28
LDL receptor 28
IL-1 27
FVIII 27
Ang II 26
caspase-3 26
MMP-3 25
histidine-rich glycoprotein 25
PCI 25
vasopressin 25
thrombospondin 25
Net 25
leptin 25
hepatocyte growth factor 25
LRP 25
apolipoprotein 25
ANOVA 25
all-trans 24
lactate dehydrogenase 24
transforming growth factor-beta 24
tumor necrosis factor alpha 24
factor XIIIa 24
IL-8 24
arginine vasopressin 24
platelet-derived growth factor 24
p38 24
growth hormone 23
more...
Disease
stroke 2228
acute myocardial infarction 695
myocardial infarction 560
ischemia 449
cancer 342
atherosclerosis 308
tumor 276
hypertension 269
cerebral ischemia 245
diabetes 240
pulmonary embolism 231
cardiovascular disease 182
SDS 176
melanoma 166
deep vein thrombosis 159
coronary artery disease 143
disseminated intravascular coagulation 122
cerebral infarction 114
obesity 107
coronary heart disease 102
coronary thrombosis 101
Thrombus 91
coagulopathy 91
sepsis 85
Ischemic stroke 82
plaque 78
carcinoma 77
myocardial ischemia 77
vascular disease 76
Alzheimer's disease 75
sepsis 74
breast cancer 71
subarachnoid hemorrhage 71
systemic lupus erythematosus 68
neurological disease 67
unstable angina 65
SEM 64
heart failure 63
type 2 diabetes 62
hepatocellular carcinoma 57
hyperlipidemia 54
Acute Stroke 53
hemiparesis 50
thrombocytopenia 50
metastases 49
lupus 49
hyperglycemia 43
depression 43
cirrhosis 43
brain edema 42
lupus 42
tumor growth 41
congestive heart failure 41
venous stasis 37
aphasia 37
pneumonia 35
dementia 35
renal disease 34
transient ischemic attack 32
veno-occlusive disease 32
hypercholesterolemia 32
von Willebrand disease 32
preeclampsia 31
HIV 31
leukemia 31
antiphospholipid syndrome 30
essential hypertension 30
hyperinsulinemia 29
dyslipidemia 29
pulmonary hypertension 29
heart disease 28
metabolic syndrome 28
liver disease 28
cold 27
haemophilia 27
acute promyelocytic leukemia 26
multiple myeloma 26
coma 26
fibrosarcoma 26
macular degeneration 25
glaucoma 25
empyema 24
vasculitis 24
epilepsy 23
cataract 22
coronary occlusion 22
cerebral vasospasm 22
encephalopathy 22
cytomegalovirus 22
DWI 22
rheumatoid arthritis 21
Adhesion 21
MCF 21
hyperhomocysteinemia 20
renal failure 20
arthritis 20
PLAT 20
retinopathy 19
respiratory failure 19
hydrocephalus 19
tumor progression 19
microalbuminuria 19
intraocular pressure 19
colorectal cancer 19
Haemophilia 18
cerebral embolism 18
endocarditis 18
glucose intolerance 18
nephrotic syndrome 18
neuroblastoma 17
ventricular fibrillation 17
Evans 17
anemia 17
arteriosclerosis 17
psychological stress 16
lung cancer 16
virus infection 16
peritonitis 16
glioma 16
multiple sclerosis 16
dysfibrinogenemia 16
thrombocytopenic purpura 16
Blocking 16
PLG 15
anterior myocardial infarction 15
hypofibrinogenemia 15
abdominal aortic aneurysm 15
Endothelial dysfunction 15
glomerulonephritis 15
APC 15
adenocarcinoma 15
cognitive impairment 15
hepatic veno-occlusive disease 15
uterus 15
infertility 14
West 14
colon cancer 14
acute renal failure 14
embryonal carcinoma 14
peripheral vascular disease 14
asthma 14
Thrombophilia 13
abortion 13
inferior myocardial infarction 13
squamous cell carcinoma 13
bacteremia 13
aqueous humor 13
retinal detachment 12
malaria 12
prostate cancer 12
diabetic nephropathy 12
Kawasaki disease 12
carcinogenesis 12
right heart failure 12
immunodeficiency 12
rare disease 12
acute myeloid leukemia 12
sickle cell disease 12
lymphoma 12
amyloidosis 12
more...
Symptom
chest pain 104
pain 95
angina 69
functional recovery 53
anesthesia 50
hypothermia 46
seizures 44
weakness 36
respiratory distress 32
hemiplegia 29
dyspnea 28
overweight 26
dysarthria 22
headache 18
abdominal pain 17
syncope 13
collapse 12
vomiting 11
spasm 11
nausea 11
hyperoxia 11
shortness of breath 9
neurological disability 9
ataxia 8
diarrhea 7
back pain 7
discomfort 7
discomfort 7
exhaustion 7
paraparesis 6
dizziness 6
tremor 6
facial droop 6
fatigue 6
analgesia 6
consciousness disturbance 6
numbness 6
starvation 6
acute stress 5
regurgitation 5
tachypnea 5
agitation 5
hemoptysis 5
cyanosis 5
neck pain 5
exertional dyspnea 4
cough 4
pelvic pain 4
flank pain 4
disturbed balance 4
flushing 4
hepatomegaly 4
vertigo 4
chills 4
livedo 4
dysesthesia 3
exertional angina 3
blurred vision 3
low back pain 3
lethargy 3
persistent cough 2
pleuritic chest pain 2
rigors 2
nasal discharge 2
constipation 2
paresis 2
stridor 2
sleepiness 2
neuralgia 2
anorexia 2
Fluctuation 2
facial pain 2
erythema 2
hypercapnia 2
incoordination 2
forgetfulness 2
leg pain 2
thinning 2
epigastric pain 2
nausea and vomiting 2
presyncope 2
Scratch 1
dark urine 1
orthopnea 1
monoplegia 1
snoring 1
apathy 1
Lower extremity weakness 1
photophobia 1
stomach pain 1
rhinorrhea 1
paresthesia 1
intestinal bleeding 1
dystonia 1
localized edema 1
bradykinesia 1
tonic-clonic seizure 1
Anoxia 1
Mental status changes 1
tinnitus 1
thoracic back pain 1
night sweats 1
Upper back pain 1
productive cough 1
dental pain 1
HSA 1
acute abdominal pain 1
sore throat 1
clumsiness 1
arm weakness 1
hepatosplenomegaly 1
hip pain 1
neck stiffness 1
hyperemesis gravidarum 1
finger pain 1
hypoproteinemia 1
POA 1
acute pain 1
colic 1
atypical chest pain 1
Catch 1
cachexia 1
Livedoid 1
non-productive cough 1
acute abdomen 1
renal colic 1
Drug
uPA 386
lysine 325
Cardiovasc 187
Alteplase 98
Alteplase 91
Streptokinase 91
Alteplase 88
Urokinase 79
Asn 43
DDAVP 43
DDAVP 42
TAT 32
Dermatol 30
nitroglycerin 24
Aprotinin 22
Activase 22
Gel 20
Dial 19
CSF 19
CaCl2 15
CaCl2 15
CaCl2 15
Nephron 14
MAP 14
ascorbate 14
Retinoic acid 14
DFP 12
Tenecteplase 12
Nephron 12
Argatroban 12
G418 12
Antithrombin III 11
ABC 10
ACT 10
Optison 10
IFN-gamma 10
Monit 9
Angiotensin II 9
balanced salt solution 8
FeCl3 8
Fragment 8
EE2 8
Fluorescein 7
Ancrod 7
SF6 7
p75 7
TTC 6
Gelatin 6
CTA 6
Clopidogrel 6
MRC 6
ROC 6
ROS 6
Simvastatin 6
Ethanol 6
Abciximab 6
Ringer's solution 6
Fluorescein 6
vitamin E 5
Ginseng 5
Glucagon 5
Amiloride 5
Iloprost 5
IL-2 5
CPR 5
Dalteparin 5
Amiloride 5
EPA 5
DNase I 5
Desmoteplase 5
Pamiteplase 4
Monteplase 4
Serum albumin 4
Hirulog 4
G-CSF 4
Captopril 4
Pravastatin 4
Alliance 4
Optison 4
THF 4
PTC 4
LMWH 4
Gemfibrozil 4
Lanoteplase 4
CCL 3
Fondaparinux 3
Diurnal 3
citric acid 3
Sodium nitroprusside 3
C3F8 3
Histamine 3
Cilostazol 3
Troglitazone 3
Coumadin 3
Eptifibatide 3
ICI 3
ADM 3
Vitamin E 3
Iopromide 3
PTH 3
Vitamin B12 3
Ramipril 3
Prolyse 3
Batroxobin 3
Forskolin 3
Gliclazide 3
NH3 2
TAK 2
TiO2 2
Albumin 2
Monensin 2
Ranibizumab 2
Polyacrylic acid 2
AMC 2
Vena 2
Wine 2
Poloxamer 188 2
Enalaprilat 2
Growth hormone 2
Propofol 2
Isotretinoin 2
Enalaprilat 2
GHRP 2
Desmopressin acetate 2
Lovastatin 2
Norplant 2
Misoprostol 2
lactose 2
Trental 2
Aliskiren 2
VCR 2
IL-11 2
Fragmin 2
Diphenhydramine 2
Fraction 2
NAG 2
Vena 2
caffeine 2
Thrombostat 2
Cyclandelate 1
MgSO4 1
Norplant 1
Portal 1
Cibacron Blue 1
Valsartan 1
AraC 1
Tacrolimus 1
Chloramine T 1
Foscavir 1
Acyclovir 1
Depo-Provera 1
Poloxamer 1
Taxol 1
Biopolymers 1
Hydrochlorothiazide 1
Tannic acid 1
CGS 13080 1
Dihydrotestosterone 1
Pulmozyme 1
Bayer 1
more...
Enzyme
tissue plasminogen activator 11311
urokinase-type plasminogen activator 2035
plasmin 1564
thrombin 1062
APC 359
thromboplastin 297
trypsin 184
kallikrein 109
mitogen-activated protein kinase 88
collagenase 69
elastase 67
renin 56
protein kinase C 55
thrombin-activatable fibrinolysis inhibitor 55
ACE 51
protein kinase 48
chymotrypsin 43
peroxidase 42
creatine kinase 42
ERK 41
neutrophil elastase 36
MMP-3 36
DNase 34
TAT 32
carboxypeptidase B 32
MMP 31
matrix metalloproteinase 9 30
superoxide dismutase 26
lactate dehydrogenase 25
caspase-3 22
deoxyribonuclease 22
ancrod 22
deoxyribonuclease 22
NO synthase 20
matrix metalloproteinase 2 20
cathepsin D 18
phosphodiesterase 18
focal adhesion kinase 18
tissue kallikrein 17
reverse transcriptase 17
cathepsin G 16
luciferase 15
RNase 15
RNase 15
enolase 15
lipoprotein lipase 14
catalase 13
phospholipase A2 13
alkaline phosphatase 13
transglutaminase 12
beta-galactosidase 12
proteasome 12
hyaluronidase 11
adenylate cyclase 11
dihydrofolate reductase 11
tryptase 11
endoglycosidase H 11
glutathione S-transferase 11
BMT 10
apyrase 10
CPN 10
chondroitinase 10
chondroitinase 10
deaminase 10
glyceraldehyde-3-phosphate dehydrogenase 10
PNGase F 10
ribonuclease 9
lipoxygenase 9
chloramphenicol acetyltransferase 9
ribonuclease 9
glyceraldehyde-3-phosphate dehydrogenase 9
heparinase 9
phospholipase C 8
aspartate aminotransferase 8
interstitial collagenase 8
subtilisin 8
NADPH oxidase 7
AMPK 7
PARP 7
methylenetetrahydrofolate reductase 7
methylenetetrahydrofolate reductase 7
RNA polymerase 7
furin 7
neuropsin 7
ATPase 7
ADPase 7
glyceraldehyde-3-phosphate dehydrogenase 6
NADPH oxidase 6
neuropsin 6
chymase 6
cathepsin B 6
Hageman factor 6
thromboxane synthase 6
neuraminidase 6
MIP 6
glyceraldehyde-3-phosphate dehydrogenase 6
ACS 6
glyceraldehyde-3-phosphate dehydrogenase 6
GSK 6
MEK 6
CD10 6
PTA 5
alanine aminotransferase 5
pepsin 5
CAD 5
CAD 5
thymidine kinase 5
CPR 5
papain 5
CAD 5
sialyltransferase 5
sialyltransferase 5
sialyltransferase 5
guanylate cyclase 4
phosphatidylinositol 3-kinase 4
acetylcholinesterase 4
MAP 4
tyrosine hydroxylase 4
DNA polymerase 4
FAST 4
NOS 4
calcineurin 4
transcriptase 4
clotting enzyme 4
endonuclease 4
cholinesterase 4
heme oxygenase 3
matriptase 3
hyaluronidase 3
BAL 3
lysozyme 3
macrophage elastase 3
caspase-9 3
PAL 3
3-hydroxy-3-methylglutaryl coenzyme A reductase 3
thermolysin 3
xanthine oxidase 3
matriptase 3
firefly luciferase 3
PAL 3
type III procollagen 3
granzyme B 3
gamma-glutamyl transpeptidase 3
phosphoglycerate kinase 3
factor C 3
S1 nuclease 3
chymosin 2
hexosaminidase 2
PDE 2
3-hydroxy-3-methylglutaryl-CoA reductase 2
choline acetyltransferase 2
phosphoribulokinase 2
AST 2
succinyl-CoA synthetase 2
pyruvate kinase 2
phosphoinositide 3-kinase 2
paraoxonase 2
hepsin 2
cathepsin H 2
TdT 2
more...
Compound
Dec 794
Clin 638
Cardiol 440
lysine 416
DNA 324
arginine 256
serine 251
glucose 232
sodium 218
oxygen 203
calcium 199
SDS 187
sulfate 154
acetate 151
Fibrin 148
Plasmin 146
prostacyclin 140
Fibrinogen 136
ADP 127
Thrombin 126
nitric oxide 117
ADP 100
ADP 100
Heparin 98
Cereb 95
water 90
cAMP 79
galactose 78
TNF 75
TPA 74
TPA 74
retinoic acid 74
ASA 72
alanine 70
FDP 67
His 66
cysteine 60
Gly 58
ACS 55
homocysteine 55
Asp 53
copper 52
Phe 52
methionine 49
phosphate 48
glutamate 47
AMP 45
creatinine 45
leucine 44
NH2 41
EDTA 40
salt 39
ethanol 37
tyrosine 37
6-aminohexanoic acid 36
glutamic acid 36
6-aminohexanoic acid 36
threonine 35
zinc 35
Insulin 34
PAR 34
PEG 32
TEM 32
urea 32
NMDA 32
EDTA 32
MDA 31
ATP 29
Ile 26
iron 26
glutamine 25
hydrogen 24
Tranexamic acid 24
CO2 24
aldosterone 23
ammonium 22
Estrogen 22
guanidine 21
PEG 21
asparagine 21
proline 21
COS 20
Bradykinin 20
Optimal 19
Dial 19
DIC 19
prostaglandin E1 19
aspartic acid 18
Triton X-100 18
Warfarin 18
aspartic acid 18
nitrate 17
nitrogen 17
MCA 17
MCA 17
Neuronal 17
tryptophan 17
Serine 17
iodine 16
bromide 16
HCl 16
Angiotensin II 16
PMA 16
aspartic acid 15
aspartic acid 15
hyaluronic acid 15
PMA 15
CaCl2 15
GlcNAc 14
Edaravone 14
tryptophan 14
potassium 14
tryptophan 14
FCB 14
tryptophan 14
cGMP 14
Ang II 14
Tris 14
5-HT 13
ammonia 13
acetic acid 13
PAP 12
PAP 12
aminomethyl 12
PAP 12
Salt 12
PAP 12
Dexamethasone 11
Cycloheximide 11
TOF 11
Argatroban 11
valine 11
TCA 10
Cholesterol 10
noradrenaline 10
GSH 10
Dextran 10
barium 10
GSH 10
cyclohexane 10
THP 10
Fibrinopeptide A 10
DEAE 10
Glutamate 10
THP 10
Phorbol 10
Desmopressin 9
Progesterone 9
nickel 9
Factor X 9
Atorvastatin 9
Estradiol 8
MTT 8
fluorine 8
TXA2 8
silver 8
Evans Blue 8
phenol 8
Fucoidan 8
hexose 8
more...