Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.68 (
tissue plasminogen activator
)
11,311
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A family is reported in which a pair of brothers has developed recurrent venous thromboses, which have been shown in one brother (the proband) to result from a reduced level of tissue plasminogen activator (t-PA) activity. Both brothers have also developed multiple synchronous and metachronous colorectal adenomas. Other pedigree members have developed colon cancers, but not multiple colonic tumours. We have shown that HNPCC and FAP/
AAPC
are unlikely causes of the family's phenotypes. Previous studies have found low levels of
t-PA
in sporadic colon tumours. In this family, mutations in the
t-PA
gene, at a linked locus, or at a locus controlling
t-PA
activity/release may modify the colon tumour phenotype to cause multiple lesions.
...
PMID:Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity. 911 41
