Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.64 (proteinase K)
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Human Gene/Protein
ScRG-1 11.9
Lon protease homolog 11.3
EIF3L 11.3
FVT-1 11.3
Gp110 10.9
P24A 10.9
probable transposase 10.6
Metaxin 1 10.6
TMEM190 10.6
HTF1 9.9
CaT2 9.9
SPRK 9.8
RNF180 9.8
GBP-2 9.8
RNase K 9.8
MMP-27 9.6
synaptopodin 2 9.6
Serine proteinase inhibitor 9.6
SYNPO 9.6
RPA4 9.5
PSL1 9.5
PrP amyloid 9.4
collagenous Alzheimer amyloid plaque component 9.3
GA protein 9.3
STS protein 9.3
MOSP 9.3
Proteinase 9.3
SYNPO2 9.2
KLHL7 9.2
PrP 9.1
MAN1A1 8.9
STV1 8.9
CENP-Q 8.8
pancreatic elastase I 8.8
UDPase 8.8
olfactomedin-like 8.8
O-sialoglycoprotein endopeptidase 8.8
KCTD1 8.8
prion protein 8.7
AW-1 8.7
VPH1 8.7
PDIP38 8.7
TG protein 8.7
putative DNA polymerase 8.6
ldhB 8.6
Prion protein 8.6
PRS II 8.5
HSP78 8.5
tNOX 8.5
PrPLP 8.5
RPL6 8.4
X-linked protein 8.4
MTX2 8.4
myopodin 8.3
BS4 8.3
CHST1 8.3
NAP4 8.3
prion 8.2
PAO-1 8.2
GSD 8.2
AIP-1 8.1
PRB1 8.1
GANAB 8.1
AAP1 8.1
Prolyl hydroxylase domain-containing protein 2 8.1
serine:pyruvate aminotransferase 8.0
ENOX1 8.0
PRNP 8.0
MGB1 8.0
RET1 8.0
CAK1 8.0
S53 8.0
NUB1 7.9
DNA-directed DNA polymerase 7.9
Xrcc2 7.9
ribonuclease T2 7.9
NB-2 7.8
DNA topoisomerase III 7.8
RPL26 7.8
Muramidase 7.8
more...
Disease
Fruit allergy 11.9
streptoccocal 9.3
HPC4 9.0
scrapie 9.0
Post-weaning multisystemic wasting syndrome 8.9
Garre 8.8
CJD 8.5
vCJD 8.2
Gerstmann 8.2
sCJD 8.2
spongiform encephalopathy 8.0
BSE 7.7
Creutzfeldt-Jakob disease 7.7
Rhizomelic chondrodysplasia punctata 7.3
FFI 7.3
kuru 7.3
chlamydial urethritis 7.2
recurrent esophageal cancer 7.1
Potomac horse fever 6.8
Autotomy 6.8
Tubulointerstitial nephritis 6.5
BK virus infection 6.4
TGE 6.4
gum disease 6.4
encephalomyelopathy 6.3
Necrotic enteritis 6.1
Gram-negative septicemia 5.8
dermatophilosis 5.7
SDS 5.6
Copper deficiency 5.6
Legionella micdadei 5.6
XP-A 5.5
HLP 5.4
OCM 5.4
ARH 5.3
DIG 5.3
Dementia with Lewy bodies 5.2
Multiple system atrophy 5.2
plantar warts 5.2
Borna disease 5.1
BCD 5.1
REM sleep behavior disorder 5.1
Enzyme inhibition 4.9
IS3 4.9
CAA 4.9
SME 4.9
AHL 4.9
spotted fever 4.9
PARK7 4.9
Tauopathies 4.9
conversion reaction 4.9
GS1 4.8
LDS 4.7
HRA 4.7
NPHP1 4.7
juvenile periodontitis 4.7
blood cancer 4.7
Brucella abortus 4.6
Diffuse idiopathic skeletal hyperostosis 4.6
leptospirosis 4.6
Mediterranean spotted fever 4.6
CAA 4.6
Liposarcoma 4.6
hereditary elliptocytosis 4.6
CM1 4.5
human granulocytic ehrlichiosis 4.5
gonococcal urethritis 4.5
LQT1 4.5
Infectious bursal disease 4.5
SD1 4.4
scrub typhus 4.4
Shigella sonnei 4.4
relapsing fever 4.3
FTLD 4.3
LAP 4.3
aminoaciduria 4.2
terminal disease 4.2
histiocytic lymphoma 4.2
VPI 4.1
microsporidiosis 4.1
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Symptom
male subfertility 4.9
No adverse effect 4.6
microbial colonization 3.9
POA 3.9
halitosis 3.7
eds 2.9
myoclonus 2.9
insomnia 2.7
ataxia 2.3
tremor 1.8
bradykinesia 1.7
pallor 1.6
paraparesis 1.5
starvation 1.5
HSA 1.4
cerebellar ataxia 1.1
memory loss 1.1
agitation 1.0
sleepiness 0.9
splenomegaly 0.7
Ill 0.5
cachexia 0.5
collapse 0.5
diarrhea 0.4
flushing 0.3
vertigo 0.1
acidity 0.0
erythema -0.7
nausea -1.6
headache -2.8
seizures -3.4
pain -5.1
Drug
C14H16O2 12.9
Celsis 10.1
Sodium carbonate 8.2
Polaprezinc 8.0
Pronase 7.4
mepivacaine hydrochloride 7.1
Acetic Acid 6.5
Azacytidine 6.4
Ddc 6.3
Onconase 6.2
Papain 6.1
FSH-beta 6.0
Asparaginase 5.9
FSH-beta 5.9
KAN 5.8
DNase I 5.7
FSH-beta 5.7
Iodixanol 5.5
L-Asparaginase 5.5
CrCl3 5.4
SBT 5.3
Diamminedichloroplatinum 5.2
Ethylenediamine 5.2
Ammonium chloride 5.1
Giardiasis 5.1
Rasburicase 5.0
Furan 4.8
K-252a 4.5
FLP 4.4
NaI 4.4
NaI 4.4
NaI 4.4
NaI 4.4
Lugol 4.3
all-trans-retinol 4.3
Doyle 4.3
MDM 4.2
ZnCl2 4.2
ZnCl2 4.2
NBT 4.1
DBS 4.1
Hyaluronidase 4.1
Maltose 4.1
ISP 4.0
Bifidobacterium 4.0
Hyaluronidase 4.0
Asn 3.8
Gel 3.8
PPA 3.7
CFS 3.6
Alanine 3.5
NAG 3.4
Paraffin 3.4
Glycerol 3.3
CIA 3.3
ABC 3.3
lysine 3.2
BoNT/A 3.2
Adenosine triphosphate 3.1
DFP 3.1
TAK 3.0
Hypaque 2.8
Etoposide 2.8
MRC 2.8
Fragment 2.8
L-tyrosine 2.7
RFP 2.7
NADH 2.7
Hypaque 2.7
PCP 2.7
CoCl2 2.6
CoCl2 2.6
Fraction 2.6
Honey 2.6
Meth 2.5
IL-1ra 2.5
FeCl3 2.5
NH3 2.5
IPM 2.4
Mutagen 2.4
more...
Enzyme
proteinase K 12.9
protease do 11.3
thermitase 10.2
actinase E 9.5
retinol isomerase 9.0
proteinase yscB 8.4
indolepyruvate decarboxylase 8.4
subtilisin 8.2
glycoprotease 8.0
Streptomyces griseus protease B 7.8
carboxypeptidase II 7.7
cucumisin 7.7
thermolysin 7.6
glycerophosphodiester phosphodiesterase 7.5
prozyme 7.5
endoproteinase Glu-C 7.4
chymotrypsin 7.3
CBPP 7.3
histidine permease 7.3
chymotrypsin C 7.3
proteinase A 7.2
KLK13 7.2
PHB depolymerase 7.1
proteinase A 7.0
signal peptidase II 6.9
papain 6.9
lambda exonuclease 6.8
cytochrome b6/f complex 6.8
carboxypeptidase S 6.7
pepsin 6.7
trypsin 6.7
bromelain 6.6
endoglycoceramidase 6.6
splicing endonuclease 6.6
ubiquinol-cytochrome c oxidoreductase 6.5
exonuclease V 6.5
EC 2.6.1.16 6.4
DNase 6.4
lysostaphin 6.3
monoacylglycerol acyltransferase 6.3
bromelin 6.2
alpha-lytic protease 6.2
site-1 protease 6.1
Fpg protein 6.1
endoglycosidase H 6.1
ficin 6.1
Escherichia coli exonuclease III 6.1
carboxypeptidase Y 6.0
aminopeptidase I 6.0
clostripain 6.0
RNase 6.0
hatching enzyme 5.9
AiiA 5.9
cystathionine gamma-lyase 5.9
3'-exonuclease 5.9
deoxyribonuclease 5.9
micrococcal nuclease 5.9
RNase T1 5.8
acyl-CoA oxidase 5.8
diol dehydratase 5.8
glycerol dehydratase 5.8
RNase 5.7
endoproteinase Asp-N 5.7
proprotein convertase 5.6
elastase 5.6
BBE 5.6
lysyl endopeptidase 5.6
endo-beta-galactosidase 5.6
chondroitinase 5.5
polynucleotide kinase 5.5
dehydroquinase 5.5
deoxyribonuclease 5.5
chondroitinase 5.5
beta-1,3-glucanase 5.5
beta-1,3-glucanase 5.5
hydroxypyruvate reductase 5.5
KAT 5.5
transhydrogenase 5.5
alpha-amylase 5.4
heparinase 5.4
more...
Compound
C14H16O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
N-Nitrosodicyclohexylamine 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
more...