Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.64 (proteinase K)
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Human Gene/Protein
ScRG-1 11.9
EIF3L 11.3
FVT-1 11.3
Lon protease homolog 11.3
P24A 10.9
Gp110 10.9
TMEM190 10.6
Metaxin 1 10.6
probable transposase 10.6
CaT2 9.9
HTF1 9.9
RNF180 9.8
SPRK 9.8
RNase K 9.8
GBP-2 9.8
MMP-27 9.6
SYNPO 9.6
Serine proteinase inhibitor 9.6
synaptopodin 2 9.6
RPA4 9.5
PSL1 9.5
PrP amyloid 9.4
MOSP 9.3
GA protein 9.3
collagenous Alzheimer amyloid plaque component 9.3
STS protein 9.3
Proteinase 9.3
SYNPO2 9.2
KLHL7 9.2
PrP 9.1
MAN1A1 8.9
STV1 8.9
CENP-Q 8.8
pancreatic elastase I 8.8
UDPase 8.8
olfactomedin-like 8.8
O-sialoglycoprotein endopeptidase 8.8
KCTD1 8.8
prion protein 8.7
PDIP38 8.7
TG protein 8.7
AW-1 8.7
VPH1 8.7
ldhB 8.6
putative DNA polymerase 8.6
Prion protein 8.6
PRS II 8.5
HSP78 8.5
PrPLP 8.5
tNOX 8.5
RPL6 8.4
X-linked protein 8.4
MTX2 8.4
myopodin 8.3
BS4 8.3
NAP4 8.3
CHST1 8.3
prion 8.2
PAO-1 8.2
GSD 8.2
GANAB 8.1
AIP-1 8.1
PRB1 8.1
AAP1 8.1
Prolyl hydroxylase domain-containing protein 2 8.1
ENOX1 8.0
serine:pyruvate aminotransferase 8.0
PRNP 8.0
CAK1 8.0
MGB1 8.0
RET1 8.0
S53 8.0
NUB1 7.9
Xrcc2 7.9
DNA-directed DNA polymerase 7.9
ribonuclease T2 7.9
DNA topoisomerase III 7.8
NB-2 7.8
Ca2+-dependent activator protein for secretion 7.8
insulysin 7.8
RPL26 7.8
Muramidase 7.8
CD1B 7.8
K38 7.7
M83 7.6
UbcH6 7.6
metastasis suppressor protein 7.6
COX5A 7.6
PRS I 7.6
SPR1 7.6
DPK 7.6
serum spreading factor 7.5
prion-like protein 7.5
ISP2 7.5
collagen alpha-1 7.5
PKP1 7.4
P126 7.4
DLG4 7.4
GAX 7.4
CBPP 7.4
S100C 7.4
synapsin III 7.3
phosphoinositide phospholipase C 7.3
hAM 7.3
K77 7.3
TANGO 7.3
multispanning membrane protein 7.3
GBA1 7.3
5'-methylthioadenosine phosphorylase 7.3
ddc 7.2
AG4 7.2
3-ketoacyl-CoA thiolase 7.2
RPA3 7.2
chymotrypsin 7.1
AMY1 7.1
RNase A 7.1
NDUFS3 7.1
GSS 7.1
P54 7.1
NADE 7.1
amplified in breast cancer 1 7.0
transglutaminase 3 7.0
glycophorin B 7.0
NIFL 6.9
V1-3 6.9
Carboxypeptidase A 6.8
S52 6.8
topoisomerase II beta 6.8
Ribonuclease P 6.8
OG2 6.8
Cholesterol esterase 6.8
nicotinamide nucleotide transhydrogenase 6.8
DNase 6.8
Fibrillarin 6.7
COXIII 6.7
LYZ 6.7
DSN 6.7
CTSL 6.7
NKB1 6.7
gp180 6.7
C4BP 6.7
Band 3 protein 6.7
ADP/ATP carrier protein 6.7
H+,K+-ATPase 6.7
PTS1 receptor 6.6
cysteine desulfhydrase 6.6
440 kDa 6.6
UBB 6.6
CytB 6.6
NCR1 6.6
cyl 6.6
D53 6.6
AB3 6.6
KH1 6.6
C4S 6.6
MPS-1 6.6
Monoamine oxidase B 6.5
TCRG 6.5
MM1 6.5
nucleobindin 6.5
more...
Disease
Fruit allergy 11.9
streptoccocal 9.3
HPC4 9.0
scrapie 9.0
Post-weaning multisystemic wasting syndrome 8.9
Garre 8.8
CJD 8.5
vCJD 8.2
Gerstmann 8.2
sCJD 8.2
spongiform encephalopathy 8.0
BSE 7.7
Creutzfeldt-Jakob disease 7.7
Rhizomelic chondrodysplasia punctata 7.3
FFI 7.3
kuru 7.3
chlamydial urethritis 7.2
recurrent esophageal cancer 7.1
Potomac horse fever 6.8
Autotomy 6.8
Tubulointerstitial nephritis 6.5
BK virus infection 6.4
TGE 6.4
gum disease 6.4
encephalomyelopathy 6.3
Necrotic enteritis 6.1
Gram-negative septicemia 5.8
dermatophilosis 5.7
SDS 5.6
Copper deficiency 5.6
Legionella micdadei 5.6
XP-A 5.5
HLP 5.4
OCM 5.4
ARH 5.3
DIG 5.3
Dementia with Lewy bodies 5.2
Multiple system atrophy 5.2
plantar warts 5.2
Borna disease 5.1
BCD 5.1
REM sleep behavior disorder 5.1
Enzyme inhibition 4.9
IS3 4.9
CAA 4.9
SME 4.9
AHL 4.9
PARK7 4.9
spotted fever 4.9
Tauopathies 4.9
conversion reaction 4.9
GS1 4.8
LDS 4.7
HRA 4.7
NPHP1 4.7
juvenile periodontitis 4.7
blood cancer 4.7
Brucella abortus 4.6
Diffuse idiopathic skeletal hyperostosis 4.6
leptospirosis 4.6
Mediterranean spotted fever 4.6
CAA 4.6
Liposarcoma 4.6
hereditary elliptocytosis 4.6
CM1 4.5
human granulocytic ehrlichiosis 4.5
gonococcal urethritis 4.5
LQT1 4.5
Infectious bursal disease 4.5
SD1 4.4
scrub typhus 4.4
Shigella sonnei 4.4
relapsing fever 4.3
FTLD 4.3
LAP 4.3
aminoaciduria 4.2
terminal disease 4.2
histiocytic lymphoma 4.2
VPI 4.1
microsporidiosis 4.1
CP1 4.1
MDM 4.1
wasting 4.0
Mycoplasma 4.0
epidermodysplasia verruciformis 4.0
Aujeszky's disease 4.0
Shigella flexneri 4.0
pasteurellosis 3.9
yaws 3.9
SLS 3.9
melioidosis 3.9
vibriosis 3.9
western equine encephalomyelitis 3.9
cervicitis 3.9
MRS 3.9
SLS 3.9
Shigella dysenteriae 3.9
scalded skin syndrome 3.9
Bovine viral diarrhea 3.8
eastern equine encephalitis 3.8
TBS 3.8
IS1 3.8
scarlet fever 3.7
typhus 3.7
ISH 3.7
McArdle's disease 3.7
hepatitis G 3.7
Chlamydia trachomatis infection 3.7
hypophosphatasia 3.7
Bordetella 3.7
streptococcal pharyngitis 3.7
NMS 3.7
tyrosinemia 3.7
pseudotuberculosis 3.6
wasting syndrome 3.6
KNO 3.6
Legionella 3.6
Cutaneous leishmaniasis 3.6
urethritis 3.6
acute glomerulonephritis 3.6
AA amyloidosis 3.6
B virus infection 3.6
Campylobacter infection 3.6
hepatitis A 3.6
Stomach 3.6
Stomach 3.6
Stomach 3.6
TMD 3.6
LIN 3.5
Brucella melitensis 3.5
WSN 3.5
WSN 3.5
Haemophilus 3.5
CEM 3.5
hermaphroditism 3.5
histiocytic lymphoma 3.5
lymphogranuloma venereum 3.5
Stomach 3.5
neuroblastoma 3.5
CREST 3.5
HEP 3.4
Lyme disease 3.4
RP4 3.4
MCL 3.4
EMD 3.4
Gaucher disease 3.4
DIN 3.4
Yersinia 3.4
DIN 3.4
Wuchereria 3.4
molluscum contagiosum 3.4
systemic candidiasis 3.3
periodontitis 3.3
gonococcal 3.3
PMS 3.3
Wernicke's encephalopathy 3.3
TMD 3.3
DIP 3.3
Pick's disease 3.3
Schistosoma mansoni 3.3
more...
Symptom
male subfertility 4.9
No adverse effect 4.6
microbial colonization 3.9
POA 3.9
halitosis 3.7
eds 2.9
myoclonus 2.9
insomnia 2.7
ataxia 2.3
tremor 1.8
bradykinesia 1.7
pallor 1.6
paraparesis 1.5
starvation 1.5
HSA 1.4
cerebellar ataxia 1.1
memory loss 1.1
agitation 1.0
sleepiness 0.9
splenomegaly 0.7
Ill 0.5
cachexia 0.5
collapse 0.5
diarrhea 0.4
flushing 0.3
vertigo 0.1
acidity 0.0
erythema -0.7
nausea -1.6
headache -2.8
seizures -3.4
pain -5.1
Drug
C14H16O2 12.9
Celsis 10.1
Sodium carbonate 8.2
Polaprezinc 8.0
Pronase 7.4
mepivacaine hydrochloride 7.1
Acetic Acid 6.5
Azacytidine 6.4
Ddc 6.3
Onconase 6.2
Papain 6.1
FSH-beta 6.0
Asparaginase 5.9
FSH-beta 5.9
KAN 5.8
DNase I 5.7
FSH-beta 5.7
Iodixanol 5.5
L-Asparaginase 5.5
CrCl3 5.4
SBT 5.3
Diamminedichloroplatinum 5.2
Ethylenediamine 5.2
Ammonium chloride 5.1
Giardiasis 5.1
Rasburicase 5.0
Furan 4.8
K-252a 4.5
FLP 4.4
NaI 4.4
NaI 4.4
NaI 4.4
NaI 4.4
all-trans-retinol 4.3
Lugol 4.3
Doyle 4.3
MDM 4.2
ZnCl2 4.2
ZnCl2 4.2
NBT 4.1
DBS 4.1
Hyaluronidase 4.1
Maltose 4.1
ISP 4.0
Bifidobacterium 4.0
Hyaluronidase 4.0
Asn 3.8
Gel 3.8
PPA 3.7
CFS 3.6
Alanine 3.5
NAG 3.4
Paraffin 3.4
Glycerol 3.3
CIA 3.3
ABC 3.3
lysine 3.2
BoNT/A 3.2
Adenosine triphosphate 3.1
DFP 3.1
TAK 3.0
Hypaque 2.8
Etoposide 2.8
MRC 2.8
Fragment 2.8
L-tyrosine 2.7
RFP 2.7
NADH 2.7
Hypaque 2.7
PCP 2.7
CoCl2 2.6
CoCl2 2.6
Fraction 2.6
Honey 2.6
Meth 2.5
IL-1ra 2.5
FeCl3 2.5
NH3 2.5
IPM 2.4
Mutagen 2.4
balanced salt solution 2.3
CaCl2 2.3
CaCl2 2.3
Ranitidine 2.3
Acacia 2.3
CaCl2 2.3
Ginseng 2.2
Gelatin 2.2
Parkin 2.1
Parkin 2.1
Fructose 2.0
Ethanol 2.0
Itraconazole 2.0
-deoxyadenosine 1.9
uPA 1.9
IFN-gamma 1.8
DHT 1.8
lactose 1.7
ampicillin 1.7
citric acid 1.7
Ouabain 1.6
Alliance 1.5
AZT 1.5
Fluorescein 1.5
FAD 1.5
Biopolymers 1.5
Growth hormone 1.4
AZT 1.4
Growth hormone 1.4
Heme 1.3
Taxol 1.3
Vitamin E 1.2
Fluorescein 1.1
nitroglycerin 0.8
Nephron 0.8
Albumin 0.7
IL-2 0.7
Angiotensin II 0.6
MAP 0.6
Glutathione 0.5
ascorbate 0.4
SiO2 0.4
CSF 0.3
Indomethacin 0.3
ZnO 0.2
Spectrum -0.0
CTX -0.4
Leaf -0.5
vitamin E -1.2
Dial -2.0
Dermatol -2.5
Cardiovasc -4.7
Enzyme
proteinase K 12.9
protease do 11.3
thermitase 10.2
actinase E 9.5
retinol isomerase 9.0
indolepyruvate decarboxylase 8.4
proteinase yscB 8.4
subtilisin 8.2
glycoprotease 8.0
Streptomyces griseus protease B 7.8
cucumisin 7.7
carboxypeptidase II 7.7
thermolysin 7.6
glycerophosphodiester phosphodiesterase 7.5
prozyme 7.5
endoproteinase Glu-C 7.4
chymotrypsin 7.3
CBPP 7.3
histidine permease 7.3
chymotrypsin C 7.3
proteinase A 7.2
KLK13 7.2
PHB depolymerase 7.1
proteinase A 7.0
signal peptidase II 6.9
papain 6.9
lambda exonuclease 6.8
cytochrome b6/f complex 6.8
carboxypeptidase S 6.7
pepsin 6.7
trypsin 6.7
bromelain 6.6
endoglycoceramidase 6.6
splicing endonuclease 6.6
ubiquinol-cytochrome c oxidoreductase 6.5
exonuclease V 6.5
EC 2.6.1.16 6.4
DNase 6.4
lysostaphin 6.3
monoacylglycerol acyltransferase 6.3
bromelin 6.2
alpha-lytic protease 6.2
site-1 protease 6.1
Fpg protein 6.1
endoglycosidase H 6.1
ficin 6.1
Escherichia coli exonuclease III 6.1
carboxypeptidase Y 6.0
aminopeptidase I 6.0
clostripain 6.0
RNase 6.0
hatching enzyme 5.9
AiiA 5.9
cystathionine gamma-lyase 5.9
3'-exonuclease 5.9
deoxyribonuclease 5.9
micrococcal nuclease 5.9
RNase T1 5.8
acyl-CoA oxidase 5.8
diol dehydratase 5.8
glycerol dehydratase 5.8
RNase 5.7
endoproteinase Asp-N 5.7
proprotein convertase 5.6
elastase 5.6
BBE 5.6
lysyl endopeptidase 5.6
endo-beta-galactosidase 5.6
chondroitinase 5.5
polynucleotide kinase 5.5
dehydroquinase 5.5
deoxyribonuclease 5.5
chondroitinase 5.5
beta-1,3-glucanase 5.5
beta-1,3-glucanase 5.5
hydroxypyruvate reductase 5.5
KAT 5.5
transhydrogenase 5.5
alpha-amylase 5.4
heparinase 5.4
pyruvate formate-lyase 5.4
tyrosine decarboxylase 5.3
mannosidase II 5.3
hydroxypyruvate reductase 5.3
N-acetylglucosaminyltransferase I 5.3
SPC 5.3
chymopapain 5.3
GM3 synthase 5.2
chymopapain 5.2
arginine deiminase 5.2
alpha-sarcin 5.1
beta-amylase 5.1
mu-calpain 5.1
lactonase 5.1
pyruvate:ferredoxin oxidoreductase 5.1
venom phosphodiesterase 5.1
mannanase 5.0
endo-N 5.0
lysozyme 5.0
cutinase 5.0
PRPP synthetase 5.0
PPH 5.0
pullulanase 5.0
ribonuclease 5.0
ribonuclease 5.0
carboxypeptidase A 5.0
PNGase F 4.9
TGT 4.9
bilirubin oxidase 4.9
pyruvate oxidase 4.9
RNase P 4.9
pyruvate oxidase 4.9
alanine dehydrogenase 4.9
ADPase 4.8
S1 nuclease 4.8
hyaluronidase 4.8
neutrophil elastase 4.7
glucocerebrosidase 4.7
hyaluronidase 4.7
cathepsin G 4.7
uricase 4.7
Thy1 4.7
Pla 4.7
carboxypeptidase B 4.7
murein hydrolase 4.7
penicillin acylase 4.7
sortase A 4.7
branching enzyme 4.6
glycerophosphate acyltransferase 4.6
UDP-glucose dehydrogenase 4.6
inulinase 4.6
neuraminidase 4.6
callose synthase 4.6
enterokinase 4.5
disulfide reductase 4.5
chitosanase 4.5
chitinase 4.5
neuropathy target esterase 4.5
inulinase 4.5
phenylalanyl-tRNA synthetase 4.4
azoreductase 4.4
alpha-mannosidase 4.4
alginate lyase 4.4
catechol 2,3-dioxygenase 4.4
catechol O-methyltransferase 4.3
dextranase 4.3
transaldolase 4.3
lipase 4.3
dUTPase 4.3
m-calpain 4.3
lysine decarboxylase 4.3
PRA 4.2
acylase 4.1
ferrochelatase 4.1
pectinase 4.0
cathepsin L 4.0
prolidase 4.0
alpha-L-fucosidase 4.0
O-GlcNAc transferase 4.0
apyrase 3.9
more...
Compound
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
N-Nitrosodicyclohexylamine 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C16H20O4 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C16H20O4 12.9
C14H16O2 12.9
C14H16O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 12.9
C14H20O2 11.9
C14H20O2 11.9
C18H16O8 11.9
C18H16O8 11.9
C18H16O8 11.9
C18H16O8 11.9
C18H16O8 11.9
C14H20O2 11.9
C14H20O2 11.9
C13H14O4 11.9
C18H16O8 11.9
C18H16O8 11.9
C14H20O2 11.9
C14H20O2 11.9
C12H16O3 11.9
C18H16O8 11.9
C22H31NO3 11.9
C14H20O2 11.9
C14H20O2 11.9
C14H10O4 11.3
C14H10O4 11.3
C14H10O4 11.3
C14H10O4 11.3
C14H10O4 11.3
C14H10O4 11.3
C14H10O4 11.3
C17H20O2 11.3
C16H24O3 11.3
C14H20O2 11.3
C13H16O4 11.3
C10H13NO4 11.3
C14H12O2 11.3
C14H10O4 11.3
C14H20O2 11.3
C18H16O8 11.3
1,1,1-trifluoro-2-propanol 11.3
C14H20O2 11.3
C14H20O2 11.3
C14H18O4 11.3
C16H16O3 11.3
C14H20O2 11.3
C14H10O4 11.3
C15H20O2 11.3
C14H10O4 11.3
C20H26O3 11.3
C14H10O4 11.3
C14H20O2 11.3
C14H10O4 11.3
C14H10O4 11.3
C14H26O 10.9
C18H18O6 10.9
C14H18O3 10.9
C18H16O8 10.9
C14H10O4 10.9
C14H10O4 10.9
C14H10O4 10.9
Centaureidin 10.9
C15H22O2 10.9
C14H10O4 10.9
C14H18O3 10.9
C15H22O2 10.9
more...